糖调节异常与听力损害

doi:10.3969/j.issn.1006-7795.2015.01.019

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (1): 98-102.doi: 10.3969/j.issn.1006-7795.2015.01.019

• 糖尿病前期与神经病变 • 上一篇下一篇

糖调节异常与听力损害

卢彬¹, 段金萍², 孟岩¹, 吴小娟¹, 闫倩¹, 庄晓明¹, 刘博²

1. 首都医科大学附属复兴医院内分泌科, 北京 100038;
2. 首都医科大学附属同仁医院耳鼻喉科, 北京 100730

收稿日期:2014-09-01 出版日期:2015-02-21 发布日期:2015-01-31
通讯作者: 庄晓明 E-mail:zhuangxiaoming@163.com
基金资助:
首都十大疾病科技成果推广项目(Z121107006212005),首都医科大学附属复兴医院青年基金项目(2014YQN01).

Impaired glucose regulation and hearing impairment

Lu Bin¹, Duan Jinping², Meng Yan¹, Wu Xiaojuan¹, Yan Qian¹, Zhuang Xiaoming¹, Liu Bo²

1. Department of Endocrinology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;
2. Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2014-09-01 Online:2015-02-21 Published:2015-01-31
Supported by:
This study was supported by Capital of the Ten Major Disease Projects to Promote Scientific and Technological Achievements(Z121107006212005), Fuxing Hospital, Capital Medical University Touth Fund(2014YQN01).

摘要/Abstract

摘要： 听力损失发病率逐年升高,其中糖尿病引起的听力损失日益得到关注,主要表现为双侧对称性感音神经性聋,以高频听力下降为主.发病机制尚有待于进一步研究,目前主要认为与糖尿病微血管病变、糖尿病周围神经病变有关.临床中多应用纯音测听、畸变产物耳声发射、听性脑干反应等对听力损失特点、程度及受损部位进行评估.糖调节异常作为糖尿病前期阶段,已出现微血管病变及神经病变,使得内耳神经及滋养神经的微血管受累,最终导致听力减退,现结合国内外文献对糖调节异常与听力损害予以综述.

关键词: 糖调节异常, 听力损害, 周围神经病变

Abstract: The incidence of hearing impairment has been increasing significantly in recent years. Epidemiologic studies have demonstrated an increased risk for sensorineural hearing loss in patients with diabetes. The common features of hearing impairment are bilateral sensorineural hearing loss on high-frequency. The pathogenesis is still unconfirmed. Many studies have shown that hearing dysfunction may have a relationship with the diabetic microangiopathy and neuropathy. Pure tone audiometry, distortion product otoacoustic emission and auditory brainstem response are often used to evaluate the function of hearing. Impaired glucose regulation (IGR) is a stage which we call pre-diabetes. People with pre-diabetes often have the microangiopathy and neuropathy. Diabetic microangiopathy and neuropathy.which can damage the inner ear nerve and the microvessel nourishing the nerve to some extent. Both of them may be the causes of hearing impairment.

Key words: impaired glucose regulation, hearing impairment, peripheral neuropathy.

中图分类号:

卢彬, 段金萍, 孟岩, 吴小娟, 闫倩, 庄晓明, 刘博. 糖调节异常与听力损害[J]. 首都医科大学学报, 2015, 36(1): 98-102.

Lu Bin, Duan Jinping, Meng Yan, Wu Xiaojuan, Yan Qian, Zhuang Xiaoming, Liu Bo. Impaired glucose regulation and hearing impairment[J]. Journal of Capital Medical University, 2015, 36(1): 98-102.

参考文献

[1] 王吉耀, 廖二元, 黄从新, 等. 内科学[M]. 北京: 人民卫生出版社, 2010.
[2] Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010,362(12):1090-1101.
[3] Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults[J]. JAMA, 2013,310(9):948-959.
[4] Pleis J R,Ward B W, Lucas J W. Summary health statistics for U.S. adults: national health interview survey, 2009[J]. Vital Health Stat 10, 2010(249):1-207.
[5] Pleis J R, Schiller J S, Benson V. Summary health statistics for U.S. adults: national health interview survey, 2000[J]. Vital Health Stat 10, 2003(215):1-132.
[6] Word Health Organization. Prevention of blindness and deafness[EB/OL].[2014-01-06].http://www.who.inl/pbd/ deafness/estimates/en/.
[7] 龚敬, 刘博. 糖尿病患者听力损失的相关研究[J]. 中华耳鼻咽喉头颈外科杂志, 2014,49(9):781-785.
[8] Diabetes prevention program research group. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the diabetes prevention program[J]. Diabet Med, 2007,24(2):137-144.
[9] Cheng Y J, Gregg E W, Saaddine J B, et al. Three decade change in the prevalence of hearing impairment and its association with diabetes in the united states[J]. Prev Med, 2009,49(5):360-364.
[10] Horikawa C, Kodama S, Tanaka S, et al. Diabetes and risk of hearing impairment in adults: a meta-analysis[J]. J Clin Endocrinol Metab, 2013,98(1):51-58.
[11] 周芸, 冯文静, 刘博, 等. 糖尿病患者的位听功能状况分析[J]. 首都医科大学学报, 2012,33(6):745-749.
[12] Baiduc R R,Poling G L, Hong O, et al. Clinical measures of auditory function: the cochlea and beyond[J]. Dis Mon, 2013,59(4):147-156.
[13] Vesperini E, Giacobbe F Di, Passatore M, et al. Audiological screening in people with diabetes. First results[J]. Audiol Res, 2011,1:e8.
[14] Malucelli D A, Malucelli F J, Fonseca V R, et al. Hearing loss prevalence in patients with diabetes mellitus type 1[J]. Braz J Otorhinolaryngol, 2012,78(3):105-115.
[15] Xiao D J, Zhang Y S, Zhang Y H. Exploration of the auditory effects of diabetes mellitus using distortion product otoacoustic emissions[J]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2006,41(12):924-927.
[16] 曲雁. 糖尿病性耳聋大鼠Connexin26、Connexin30表达与耳蜗病理学变化和发病机制探讨[D]. 石家庄: 河北医科大学, 2013.
[17] Botelho C T, Carvalho S A, Silva I N. Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions[J]. Int J Audiol, 2014,53(6):402-408.
[18] Lerman-Garber I, Cuevas-Ramos D, Valdés S, et al. Sensorineural hearing loss—a common finding in early-onset type 2 diabetes mellitus[J]. Endocr Pract, 2012,18(4):549-557.
[19] Hong B N, Kang T H. Distinction between auditory electrophysiological responses in type 1 and type 2 diabetic animal models[J]. Neurosci Lett, 2014,566:309-314.
[20] Shen F C, Hsieh C J. Severity of hearing impairment is positively associated with urine albumin excretion rate in patients with type 2 diabetes[J]. J Diabetes Investig, 2014,5(6):743-747.
[21] Sunkum A J, Pingile S. A clinical study of audiological profile in diabetes mellitus patients[J]. Eur Arch Otorhinolaryngol, 2013,270(3):875-879.
[22] Nondahl D M, Shi X, Cruickshanks K J, et al. Notched audiograms and noise exposure history in older adults[J]. Ear Hear, 2009,30(6):696-703.
[23] 黄灿, 辛雅萍, 任健, 等. 2型糖尿病患者听力损失的相关因素研究[J]. 听力及言语疾病杂志,2012,20(3):217-220.
[24] Bainbridge K E, Hoffman H J, Cowie C C. Risk factors for hearing impairment among US Adults with diabetes: National Health and Nutrition Examination Survey 1999-2004[J]. Diabetes Care, 2011,34(7):1540-1545.
[25] 雒富基, 陈小婉, 罗维民. 糖尿病早期内耳损伤听力学改变的实验研究[J]. 听力学及言语疾病杂志, 2009(3):265-267.
[26] 张永胜, 张玉海, 肖大江, 等. 糖尿病大鼠耳蜗病变的形态学观察[J]. 中华耳鼻喉头颈外科杂志, 2008,43(1):64-66.
[27] Fukushima H, Cureoglu S, Schachern P A, et al. Effects of type 2 diabetes mellitus on cochlear structure in humans[J]. Arch Otolaryngol Head Neck Surg, 2006,132(9):934-938.
[28] [No authors listed]. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group[J].N Engl J Med,1993,329(14):977-986
[29] 黄辉东. 糖尿病周围神经病变的发病机制及药物治疗[J]. 中国实用医药, 2013,8(16):257-258.
[30] Lehtinen J M, Niskanen L, Hyvonen K, et al. Nerve function and its determinants in patients with newly-diagnosed type 2(non-insulin-dependent) diabetes mellitus and in control subjects a 5-year follow-up[J]. Diabetologia, 1993,36(1):68-72.
[31] Sumner C J, Sheth S, Griffin J W, et al. The spectrum of neuropathy in diabetes and impaired glucose tolerance[J]. Neurology, 2003,60(1):108-111.
[32] Ziegler D, Rathmann W, Dickhaus T, et al. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3[J]. Diabetes Care, 2008,31(3):464-469.
[33] 沈琴, 贾伟平, 包玉倩, 等. 上海社区糖尿病及糖调节受损人群周围神经病变的横断面调查[J]. 上海医学, 2009,32(5):374-378.
[34] Ishikawa T, Naito Y, Taniguchi K. Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus[J]. Diabetologia, 1995,38(6):649-655.
[35] Ryu O H, Choi M G, Park C H, et al. Hyperglycemia as a potential prognostic factor of idiopathic sudden sensorineural hearing loss[J]. Otolaryngol Head Neck Surg, 2014,150(5):853-858.
[36] Li G, Zhang P, Wang J, et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study[J]. Lancet, 2008,371(9626):1783-1789.
[37] Tuomilehto J,Lindstrm J, Eriksson JG,et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance[J].N Engl J Med,2001,344(18):1343-1350.
[38] Plantinga L C, Crews D C, Coresh J, et al. Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes[J]. Clin J Am Soc Nephrol, 2010,5(4):673-682.
[39] Divisova S, Vlckova E, Hnojcikova M, et al. Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres[J]. J Peripher Nerv Syst, 2012,17(3):341-350.

糖调节异常与听力损害

Impaired glucose regulation and hearing impairment

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