关键词: 冻融胚胎移植, 多次胚胎种植失败, 促性腺激素释放激素-激动剂, 激素替代周期

Abstract:

Objective To investigate the clinical value of a gonadotropin-releasing hormone agonist(GnRHa) suppression protocol on multiple implantation failed patients undergoing frozen-embryo transfer(FET) cycles. Methods A total of 174 women undergoing FET cycles with a history of multiple implantation failure in our center from December, 2013 to December, 2014 were retrospectively analyzed. Patients were divided into two groups: 78 women in group A experienced a GnRHa suppression protocol, and 96 women in group B experienced a normal hormone replacement therapy(HRT). The clinical outcomes were compared between the two groups. Results Patients in the two groups had similar baseline characteristics, including duration of infertility, age, body mass index and basal endocrine level. There were no significant differences between the two groups in the number of transferred and high-quality embryos, the survival rate of frozen embryos, endometrial thickness, the implantation rate(22.8% vs 19.8%), clinical pregnancy rate(42.3% vs 37.5%), and early miscarriage rate(9.1% vs 11.1%). Conclusion This study found that the implantation rate and clinical pregnancy rate in the GnRHa suppression group experienced a tendency to increase in the patients with a history of multiple implantation failure, compared to the normal HRT group, but the difference was not statistically significant. A larger sample size may be needed for the further study.

Key words: frozen-thawed embryo transfer(FET), multiple implantation failure, gonadotropin-releasing hormone agonists(GnRHa), hormone replacement therapy(HRT)