具有梦境展现行为的阻塞性睡眠呼吸暂停综合征的多导睡眠监测特点

doi:10.3969/j.issn.1006-7795.2016.03.025

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (3): 376-381.doi: 10.3969/j.issn.1006-7795.2016.03.025

具有梦境展现行为的阻塞性睡眠呼吸暂停综合征的多导睡眠监测特点

畅怡¹, 聂秀红¹, 魏兵¹, 肖汉¹, 张连国¹, 李艳¹, 詹淑琴², 陈彪^2,3

1. 首都医科大学宣武医院呼吸内科, 北京 100053;
2. 首都医科大学宣武医院神经内科, 北京 100053;
3. 北京脑重大疾病研究院帕金森病研究所和北京市帕金森病研究重点实验室, 北京 100053

收稿日期:2016-01-29 出版日期:2016-06-21 发布日期:2016-06-13
通讯作者: 陈彪 E-mail:pbchan90@gmail.com
基金资助:
国家高技术研究发展计划(863计划)资助项目(2012AA02A514),国家重点基础研究发展计划项目(2011CB504101)。

Polysomnographic characteristics of obstructive sleep apnea syndrome with dream enacting behavior

Chang Yi¹, Nie Xiuhong¹, Wei Bing¹, Xiao Han¹, Zhang Lianguo¹, Li Yan¹, Zhan Shuqin², Chen Biao^2,3

1. Department of Respiratory Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
3. Parkinson Disease Center of Beijing Institutes for Brain Disorders and Beijing Key Laboratory on Parkinson's Disease, Beijing 100053, China

Received:2016-01-29 Online:2016-06-21 Published:2016-06-13
Supported by:
This study was supported by National High Technology Reasearch and Development Program of China(2012AA02A514); Major State Basic Research Development Program of China (973 program, 2011CB504101).

摘要/Abstract

摘要： 目的研究具有梦境展现行为(dream enacting behavior, DEB)的阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)的视频多导睡眠监测(video-polysomnography,vPSG)特点。方法选取2012年1月1日至2013年10月31日因各种睡眠主诉就诊于首都医科大学宣武医院睡眠门诊且年龄大于18岁的患者共224人。所有受试者均行快速动眼睡眠疾病(rapid eyes movement sleep behavior disorder, RBD)香港问卷(RBD questionnaire-Hong Kong,RBDQ-HK)筛查(阈值为18/19)以及一整夜vPSG检查,并分为伪RBD(Pseudo-RBD)组、OSAS组、特发性RBD (idiopathic RBD, iRBD)组并对其睡眠参数进行分析。结果伪RBD组呼吸暂停低通气指数(apnea-hypopnea index,AHI)、非快速动眼睡眠(non-rapid eye movement, NREM)期 AHI、REM期 AHI及低通气指数高于OSAS对照组,基础血氧饱和度及最低血氧饱和度则低于OSAS对照组,低通气最长时间及血氧饱和度低于90%的时间比OSAS对照组长;与iRBD组相比,伪RBD组的梦境展现行为常常在各个睡眠期的呼吸相关觉醒时出现。结论具有DEB症状的OSAS多为中重度OSAS患者,并且DEB的发作时间往往发生于呼吸暂停相关觉醒时。

关键词: 梦境展现行为, 快速动眼期睡眠行为障碍, 阻塞性睡眠呼吸暂停综合征, 视频多导睡眠监测, RBD香港问卷

Abstract: Objective To analyze the video-polysomnographic(vPSG) characteristics of obstructive sleep apnea syndrome(OSAS) with dream enacting behavior(DEB). Methods Totally 224 subjects were enrolled from sleep disease center of Xuanwu Hospital from 2012 to 2013. All subjects were undergone by rapid eyes movement (REM) sleep behavior disorder (RBD) questionnaire-Hong Kong(RBDQ-HK) at the cut-off value of 18/19 and one night vPSG. The subjects were screened into three groups(pseudo-RBD group=17;OSAS group=39;idiopathic RBD(iRBD) group=118) and the sleep apnea related parameters were compared between the three groups. Results Compared with OSAS group, pseudo-RBD patients had lower apnea hypopnea index (AHI) and hypopnea index, more severity of oxygen desaturation [baseline oxygen saturation (SpO₂) and minimum SpO₂] and longer maximum hypopnea time and<90% O₂saturation duration(P <0.05). Compared with iRBD group, the abnormal behaviors displayed from arousals across the different sleep stages. Conclusion The symptoms of DEB more often occurred during respiratory-related arousals in the moderate to severe patients with OSAS.

Key words: dream enacting behavior, REM sleep behavior disorder (RBD), obstructive sleep apnea syndrome (OSAS), polysomnography, REM sleep behavior disorder questionnaire-Hong Kong(RBDQ-HK)

中图分类号:

R338.63

畅怡, 聂秀红, 魏兵, 肖汉, 张连国, 李艳, 詹淑琴, 陈彪. 具有梦境展现行为的阻塞性睡眠呼吸暂停综合征的多导睡眠监测特点[J]. 首都医科大学学报, 2016, 37(3): 376-381.

Chang Yi, Nie Xiuhong, Wei Bing, Xiao Han, Zhang Lianguo, Li Yan, Zhan Shuqin, Chen Biao. Polysomnographic characteristics of obstructive sleep apnea syndrome with dream enacting behavior[J]. Journal of Capital Medical University, 2016, 37(3): 376-381.

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具有梦境展现行为的阻塞性睡眠呼吸暂停综合征的多导睡眠监测特点

Polysomnographic characteristics of obstructive sleep apnea syndrome with dream enacting behavior

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