NADPH氧化酶在呼吸道黏膜炎性疾病中的研究进展

doi:10.3969/j.issn.1006-7795.2018.01.013

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (1): 69-73.doi: 10.3969/j.issn.1006-7795.2018.01.013

• 鼻炎和鼻窦炎的基础研究 • 上一篇下一篇

NADPH氧化酶在呼吸道黏膜炎性疾病中的研究进展

郑凯莉¹, 王向东¹, 张罗^1,2

1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京市耳鼻咽喉科研究所教育部耳鼻咽喉头颈科学重点实验室鼻病研究北京市重点实验室, 北京 100730;
2. 首都医科大学附属北京同仁医院鼻过敏科, 北京 100730

收稿日期:2017-12-11 出版日期:2018-01-21 发布日期:2018-01-27
通讯作者: 张罗 E-mail:dr.luozhang@139.com
基金资助:
国家自然科学基金重点国际合作项目（81420108009），国家自然科学基金重点项目（81630023），国家自然科学基金面上项目（81570894），教育部长江学者和创新团队发展计划（IRT13082），北京市百千万人才工程资助项目（2016），北京市自然科学基金面上项目（7172053），北京市卫生系统高层次卫生技术人才（2009-2-007，2011-3-039，2011-3-043，2014-3-018），北京市医院管理局使命人才计划（SML20150203），北京市科技项目统筹课题（Z171100000117002）。

Research progress of NADPH oxidase in inflammatory diseases of respiratory tract

Zheng Kaili¹, Wang Xiangdong¹, Zhang Luo^1,2

1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing 100730, China;
2. Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2017-12-11 Online:2018-01-21 Published:2018-01-27
Supported by:
This study was supported by National Natural Science Foundation of China (81420108009,81630023, 81570894),Changjiang Scholars and Innovative Research Team (IRT13082), Beijing Talent Project (2016), Beijing Health Bureau Program for High Level Talents (2009-2-007, 2011-3-039, 2011-3-043, and 2014-3-018), Beijing Municipal Administration of Hospitals' Mission Plan (SML20150203), Beijing Scientific and Technological Overall Plan (Z171100000117002).

摘要/Abstract

摘要： 烟酰胺腺嘌呤二核苷磷酸（nico-tinamide adenine dinucleotide phosphate，NADPH）氧化酶最早发现于吞噬细胞的呼吸爆发，后来发现NADPH氧化酶也表达于上皮细胞、内皮细胞等非吞噬细胞中。NADPH氧化酶与活性氧（reactive oxygen species，ROS）的产生、细胞内氧化还原反应、氧化应激及信号传导密切相关，与心血管系统疾病、呼吸系统疾病等慢性病的发生发展也有一定关联。本文就NADPH氧化酶与常见呼吸道黏膜炎性疾病的研究进展做简要综述。

关键词: 烟酰胺腺嘌呤二核苷磷酸氧化酶, 活性氧, 氧化应激, 变应性鼻炎, 慢性鼻-鼻窦炎, 哮喘, 慢性阻塞性肺疾病

Abstract: Nico-tinamide adenine dinucleotide phosphate (NADPH) oxidase was first found in the respiratory burst of phagocytic cells. It was also found that NADPH oxidase was expressed in epithelial cells, endothelial cells and other non-phagocytic cells. NADPH oxidase is closely related with reactive oxygen species (ROS) production, intracellular redox reaction,oxidative stress and signal transduction. It also has certain correlation with the occurrence and development of manychronic diseases, such as cardiovascular diseases, respiratory diseases and so on. This article briefly reviews the research progress of NADPH oxidase in inflammatory diseases of respiratory tract.

Key words: nico-tinamide adenine dinucleotide phosphate (NADPH) oxidase, reactive oxygen species (ROS), oxidative stress, allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma, chronic obstructive pulmonary disease (COPD)

中图分类号:

R765

郑凯莉, 王向东, 张罗. NADPH氧化酶在呼吸道黏膜炎性疾病中的研究进展[J]. 首都医科大学学报, 2018, 39(1): 69-73.

Zheng Kaili, Wang Xiangdong, Zhang Luo. Research progress of NADPH oxidase in inflammatory diseases of respiratory tract[J]. Journal of Capital Medical University, 2018, 39(1): 69-73.

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NADPH氧化酶在呼吸道黏膜炎性疾病中的研究进展

Research progress of NADPH oxidase in inflammatory diseases of respiratory tract

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