中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床分析

doi:10.3969/j.issn.1006-7795.2018.04.011

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (4): 537-540.doi: 10.3969/j.issn.1006-7795.2018.04.011

• 缺血性脑损伤的基础与临床研究 • 上一篇下一篇

中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床分析

李力卓¹, 何松柏², 赵格晶娃³

1. 首都医科大学宣武医院急诊科国家老年疾病临床研究中心, 北京 100053;
2. 中国医科大学附属盛京医院急诊科, 沈阳 110004;
3. 首都医科大学第一临床医院15级长学制临床医学专业(儿科), 北京 100053

收稿日期:2018-05-31 出版日期:2018-07-21 发布日期:2018-07-21
通讯作者: 李力卓 E-mail:lilizhuo66@aliyun.com
基金资助:
国家自然科学基金（81660329），首都医科大学大学生创业项目（XSKY2018）。

Clinical analysis of acute isolated traumatic brain injury-associated coagulopathy in middle aged and older populations

Li Lizhuo¹, He Songbai², Zhaoge Jingwa³

1. Department of Emergency Medicine, Xuanwu Hospital, Capital Medical University, National Clinical Research for Geriatric Disorders, Beijing 100053, China;
2. Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China;
3. The First Hospital of Capital Medical University, Grade 2015, Eight-year Program of Clinical Medicine/(Pediatrics), Beijing 100053, China

Received:2018-05-31 Online:2018-07-21 Published:2018-07-21
Supported by:
This study was supported by National Natural Science Foundation of China(81660329), Capital Medical University Undergraduate Research Project (XSKY2018)。

摘要/Abstract

摘要： 目的探讨中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床特点。方法将收集于首都医科大学宣武医院和中国医科大学附属盛京医院的144例发病于2014年7月至2016年6月的急性单发性颅脑创伤的患者资料，按照1：2配组分为中老年患者组和非中老年患者组，利用χ²检验进行统计学分析，比较中老年颅脑创伤患者创伤后凝血病的发病率与非中老年患者组差异是否有统计学意义，然后对中老年患者组和非中老年患者组的凝血功能障碍指标进行分析，明确凝血障碍指标在不同组别中的差异。结果中老年急性单发性颅脑创伤患者创伤后凝血病的发病率与非中老年患者组差异有统计学意义（P<0.05，χ²=4.11）。进一步分析表明血小板（platelet，PLT）异常在中老年患者组和非中老年患者组差异有统计学意义（P<0.05，χ²=4.68），而国际标准化比值（international normalized ratio，INR）、纤维蛋白原（fibrinogen，Fg）、凝血酶原时间（prothrombin time，PT）和活化部分凝血活酶时间（activated partial thromboplastin time，APTT）在两组患者之间差异无统计学意义（P>0.05）。结论中老年急性单发性颅脑创伤患者创伤后凝血病的发病率更高，同时血小板异常更容易出现在中老年颅脑创伤性凝血病患者组内，以上特点有助于明确中老年颅脑创伤性凝血病的病理机制并指导中老年患者颅脑创伤后凝血病的诊疗。

关键词: 中老年, 急性单发性创伤性颅脑损伤, 创伤性凝血病, 凝血障碍指标

Abstract: Objective To explore the clinical characters of acute isolated traumatic brain injury-associated coagulopathy in middle aged and older populations. Methods A retrospective study was performed at Xuanwu Hospital of Capital Medical University and Shengjing Hospital of China Medical University from July 2014 to June 2016. Totally 144 cases of acute isolated traumatic brain injury were included and divided into two groups including middle aged and older patients group and non-age group with the ratio of 1:2. The chi-square analysis was used to investigate the prevalence, index and difference of coagulopathy in both groups. Results The prevalence of coagulopathy was higher in middle aged and older patients group than that of non-age group according to the chi-square analysis (P<0.05, χ²=4.11). Further, platelet count (PLT), but not international normalized ratio (INR), fibrinogen (Fg), prothrombin time (PT) and activated partial thromboplastin time (APTT),was significantly different between two groups and higher in middle aged and older patients group(P<0.05,χ²=4.68). Conclusion The higher prevalence of acute isolated traumatic brain injury-associated coagulopathy occurs in middle aged and older patients and PLT exists more likely in those populations. These findings will provide the guidance of the treatment of traumatic brain injury in middle aged and older patients in the clinical.

Key words: middle aged and older populations, acute isolated traumatic brain injury, traumatic coagulopathy, coaglution indices

中图分类号:

R641

李力卓, 何松柏, 赵格晶娃. 中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床分析[J]. 首都医科大学学报, 2018, 39(4): 537-540.

Li Lizhuo, He Songbai, Zhaoge Jingwa. Clinical analysis of acute isolated traumatic brain injury-associated coagulopathy in middle aged and older populations[J]. Journal of Capital Medical University, 2018, 39(4): 537-540.

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中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床分析

Clinical analysis of acute isolated traumatic brain injury-associated coagulopathy in middle aged and older populations

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