内镜联合蓝激光成像对萎缩及肠上皮化生的诊断价值

doi:10.3969/j.issn.1006-7795.2018.05.008

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (5): 663-668.doi: 10.3969/j.issn.1006-7795.2018.05.008

内镜联合蓝激光成像对萎缩及肠上皮化生的诊断价值

王金鹏^1,2, 翟惠虹¹, 焦月¹, 李鹏¹, 张澍田¹

1. 首都医科大学附属北京友谊医院消化内科国家消化系统疾病临床医学研究中心北京市消化疾病中心首都医科大学消化病学系消化疾病癌前病变北京市重点实验室, 北京 100050;
2. 首都医科大学附属复兴医院消化内科, 北京 100038

收稿日期:2018-07-31 出版日期:2018-09-21 发布日期:2018-10-20
通讯作者: 李鹏 E-mail:lipeng@ccmu.edu.cn
基金资助:
国家自然科学基金面上项目（81570507），国家科技部国家重点研发计划（2017YFC0113600），北京市科学技术委员会京津冀协同创新推动项目（Z171100004517009），北京市科学技术委员会（首都临床特色应用研究）（Z141107002514018）。

Value of magnifying endoscopy with blue laser imaging in diagnosis of atrophy and intestinal metaplasia

Wang Jinpeng^1,2, Zhai Huihong¹, Jiao Yue¹, Li Peng¹, Zhang Shutian¹

1. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University;National Clinical Research Center for Digestive Disease;Beijing Digestive Disease Center;Faculty of Gastroenterology, Capital Medical University;Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China;
2. Department of Gastroenterology, Fuxing Hospital, Capital Medical University, Beijing 100038, China

Received:2018-07-31 Online:2018-09-21 Published:2018-10-20
Supported by:
This study was supported by National Natural Science Foundation of China(81570507), National Key R & D Program of the Ministry of Science and Technology(2017YFC0113600), Beijing-Tianjin-Hebei Region Collaborative Innovation Promoting Project Founded by Beijing Science and Technology Commission (Z171100004517009),Beijing Municipal Science & Technology Commission(Z141107002514018).

摘要/Abstract

摘要： 目的研究放大内镜联合蓝激光成像（magnifying endoscopy with blue laser imaging，ME-BLI）在存在萎缩及肠上皮化生危险因素人群中的诊断价值。方法选取2017年2月至12月于首都医科大学附属北京友谊医院内镜中心就诊，存在萎缩或肠上皮化生危险因素的患者，进行普通白光内镜及ME-BLI检查及病理组织学检查，评价其诊断的灵敏度、特异度及准确度。结果 ME-BLI对于萎缩胃黏膜诊断的灵敏度、特异度、准确度、阳性预测值及阴性预测值分别为93.40%、71.96%、79.02%、62.26%、95.65%；对于肠上皮化生胃黏膜诊断的灵敏度、特异度、准确度、阳性预测值及阴性预测值分别为100%、92.07%、95.94%、92.31%、100%。结论应用ME-BLI对萎缩及肠上皮化生诊断有较好的灵敏度、特异度及准确度。

关键词: 放大内镜, 蓝激光, 萎缩, 肠上皮化生

Abstract: Objective To determine the utility of magnifying endoscopy with blue laser imaging(ME-BLI) in diagnosis of atrophy and intestinal metaplasia(IM) among people with risk of atrophy and IM. Methods Patients with risk factors of atrophy or IM underwent ME-BLI from Feb 2017 to Dec 2017. Biopsy was obtained in both atrophic or intestinal metaplasia lesion and gastric mucosal without atrophy or IM. The sensitivity, specificity and accuracy in both atrophy and IM with ME-BLI were calculated. Results The sensitivity, specificity, accuracy, positive and negative predictive value was 93.40%, 71.96%, 79.02%, 62.26% and 95.65% in the diagnosis of atrophy with ME-BLI respectively. The sensitivity, specificity, accuracy, positive and negative predictive value was 100%, 92.07%, 95.94%, 92.31% and 100% in the diagnosis of intestinal metaplasia, respectively. Conclusion The sensitivity, specificity and accuracy with ME-BLI in detection of atrophy and IM were good.

Key words: magnifying endoscopy, blue laser imaging, atrophy, intestinal metaplasia(IM)

中图分类号:

王金鹏, 翟惠虹, 焦月, 李鹏, 张澍田. 内镜联合蓝激光成像对萎缩及肠上皮化生的诊断价值[J]. 首都医科大学学报, 2018, 39(5): 663-668.

Wang Jinpeng, Zhai Huihong, Jiao Yue, Li Peng, Zhang Shutian. Value of magnifying endoscopy with blue laser imaging in diagnosis of atrophy and intestinal metaplasia[J]. Journal of Capital Medical University, 2018, 39(5): 663-668.

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内镜联合蓝激光成像对萎缩及肠上皮化生的诊断价值

Value of magnifying endoscopy with blue laser imaging in diagnosis of atrophy and intestinal metaplasia

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