糖尿病前期患者前庭功能损伤及其影响因素分析

doi:10.3969/j.issn.1006-7795.2019.01.003

首都医科大学学报 ›› 2019, Vol. 40 ›› Issue (1): 11-15.doi: 10.3969/j.issn.1006-7795.2019.01.003

• 糖尿病慢性合并症-听力损失与平衡障碍研究 • 上一篇下一篇

糖尿病前期患者前庭功能损伤及其影响因素分析

孟岩, 庄晓明

首都医科大学附属复兴医院内分泌科, 北京 100038

收稿日期:2018-12-06 出版日期:2019-01-21 发布日期:2019-01-23
通讯作者: 庄晓明 E-mail:Zhuangxiaoming101@163.com
基金资助:
北京市教委科技计划面上项目（KM201610025020），首都卫生发展科研专项（首发2016-2-7022，首发2018-1-1091）。

Analysis of vestibular function and risk factors in pre-diabetic mellitus patients

Meng Yan, Zhuang Xiaoming

Department of Endocrinology, Fuxing Hospital, Capital Medical University, Beijing 100038, China

Received:2018-12-06 Online:2019-01-21 Published:2019-01-23
Supported by:
This study was supported by Science and Technology Plan of Beijing Municipal Education Commission(KM201610025020), Capital Health Research and Development of Special (2016-2-7022,2018-1-1091).

摘要/Abstract

摘要： 目的比较糖尿病前期患者与健康人群前庭温度试验的差异，了解糖尿病前期是否存在前庭功能受损，并探讨糖尿病前期前庭功能受损的影响因素。方法通过口服葡萄糖耐量试验连续入组糖尿病前期患者62例，男性30例，女性32例，平均年龄（52.21±9.78）岁，对照组选取同期年龄、性别构成接近的血糖结果正常的健康体检人群44例，男性19例，女性25例，平均年龄（49.55±7.20）岁。收集受试者身高、体质量等一般资料，进行内分泌相关检查及前庭温度试验，记录双眼慢相角速度。在糖尿病前期组中分析前庭功能损害的影响因素。结果糖尿病前期组44例（71.0%）存在前庭功能损害，对照组为17例（38.6%），差异有统计学意义（P=0.001）；与对照组比较，糖尿病前期组双眼慢相角速度下降，差异有统计学意义（右眼P=0.026，左眼P=0.016）；在糖尿病前期组中，Logistic回归分析显示，随着年龄增大，糖化血红蛋白浓度升高，糖尿病前期患者出现前庭功能损害的危险性增大（年龄P=0.013，糖化血红蛋白P=0.040）。结论糖尿病前期患者前庭功能损害检出率高，表现为双侧受损。年龄、糖化血红蛋白是糖尿病前期前庭功能损害的可能危险因素。

关键词: 糖尿病前期, 前庭功能, 温度试验

Abstract: Objective To compare the differences of vestibular function among the pre-diabetic patients and the controls and to analysis the characteristics and risk factors of vestibular dysfunction in pre-diabetic patients. Methods All participants underwent oral glucose tolerance test. Sixty-two pre-diabetic patients were enrolled with 44 age-and sex-matched controls. Weight, height, and other general information are collected in all subjects. Laboratory tests and vestibular caloric test were carried out. Slow phase velocity was collected. In pre-diabetic patients, the risk factors associated with vestibular dysfunction were analyzed. Results There were 44 cases with vestibular dysfunction in pre-diabetic patients, while 17 cases in the controls, with the statistically significant difference (P=0.001). Compared with the controls, slow phase velocity decreased in both eyes in the pre-diabetic patients, with the statistically significant difference (P=0.026 for the right eyes and P=0.016 for the left eyes). Logistic regression analysis showed that as age and glycosylated hemoglobin A1c (HbA1c) increased, the pre-diabetic patients had an increased risk of vestibular dysfunction (age P=0.013, HbA1c P=0.040). Conclusion The incidence of vestibular dysfunction is increased in the pre-diabetic patients. Age and HbA1c might be risk factors associated with vestibular dysfunction in the pre-diabetic patients.

Key words: pre-diabetic mellitus, vestibular dysfunction, caloric test

中图分类号:

R587.1

孟岩, 庄晓明. 糖尿病前期患者前庭功能损伤及其影响因素分析[J]. 首都医科大学学报, 2019, 40(1): 11-15.

Meng Yan, Zhuang Xiaoming. Analysis of vestibular function and risk factors in pre-diabetic mellitus patients[J]. Journal of Capital Medical University, 2019, 40(1): 11-15.

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糖尿病前期患者前庭功能损伤及其影响因素分析

Analysis of vestibular function and risk factors in pre-diabetic mellitus patients

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