首都医科大学学报 ›› 2019, Vol. 40 ›› Issue (1): 11-15.doi: 10.3969/j.issn.1006-7795.2019.01.003

• 糖尿病慢性合并症-听力损失与平衡障碍研究 • 上一篇    下一篇

糖尿病前期患者前庭功能损伤及其影响因素分析

孟岩, 庄晓明   

  1. 首都医科大学附属复兴医院内分泌科, 北京 100038
  • 收稿日期:2018-12-06 出版日期:2019-01-21 发布日期:2019-01-23
  • 通讯作者: 庄晓明 E-mail:Zhuangxiaoming101@163.com
  • 基金资助:
    北京市教委科技计划面上项目(KM201610025020),首都卫生发展科研专项(首发2016-2-7022,首发2018-1-1091)。

Analysis of vestibular function and risk factors in pre-diabetic mellitus patients

Meng Yan, Zhuang Xiaoming   

  1. Department of Endocrinology, Fuxing Hospital, Capital Medical University, Beijing 100038, China
  • Received:2018-12-06 Online:2019-01-21 Published:2019-01-23
  • Supported by:
    This study was supported by Science and Technology Plan of Beijing Municipal Education Commission(KM201610025020), Capital Health Research and Development of Special (2016-2-7022,2018-1-1091).

摘要: 目的 比较糖尿病前期患者与健康人群前庭温度试验的差异,了解糖尿病前期是否存在前庭功能受损,并探讨糖尿病前期前庭功能受损的影响因素。方法 通过口服葡萄糖耐量试验连续入组糖尿病前期患者62例,男性30例,女性32例,平均年龄(52.21±9.78)岁,对照组选取同期年龄、性别构成接近的血糖结果正常的健康体检人群44例,男性19例,女性25例,平均年龄(49.55±7.20)岁。收集受试者身高、体质量等一般资料,进行内分泌相关检查及前庭温度试验,记录双眼慢相角速度。在糖尿病前期组中分析前庭功能损害的影响因素。结果 糖尿病前期组44例(71.0%)存在前庭功能损害,对照组为17例(38.6%),差异有统计学意义(P=0.001);与对照组比较,糖尿病前期组双眼慢相角速度下降,差异有统计学意义(右眼P=0.026,左眼P=0.016);在糖尿病前期组中,Logistic回归分析显示,随着年龄增大,糖化血红蛋白浓度升高,糖尿病前期患者出现前庭功能损害的危险性增大(年龄P=0.013,糖化血红蛋白P=0.040)。结论 糖尿病前期患者前庭功能损害检出率高,表现为双侧受损。年龄、糖化血红蛋白是糖尿病前期前庭功能损害的可能危险因素。

关键词: 糖尿病前期, 前庭功能, 温度试验

Abstract: Objective To compare the differences of vestibular function among the pre-diabetic patients and the controls and to analysis the characteristics and risk factors of vestibular dysfunction in pre-diabetic patients. Methods All participants underwent oral glucose tolerance test. Sixty-two pre-diabetic patients were enrolled with 44 age-and sex-matched controls. Weight, height, and other general information are collected in all subjects. Laboratory tests and vestibular caloric test were carried out. Slow phase velocity was collected. In pre-diabetic patients, the risk factors associated with vestibular dysfunction were analyzed. Results There were 44 cases with vestibular dysfunction in pre-diabetic patients, while 17 cases in the controls, with the statistically significant difference (P=0.001). Compared with the controls, slow phase velocity decreased in both eyes in the pre-diabetic patients, with the statistically significant difference (P=0.026 for the right eyes and P=0.016 for the left eyes). Logistic regression analysis showed that as age and glycosylated hemoglobin A1c (HbA1c) increased, the pre-diabetic patients had an increased risk of vestibular dysfunction (age P=0.013, HbA1c P=0.040). Conclusion The incidence of vestibular dysfunction is increased in the pre-diabetic patients. Age and HbA1c might be risk factors associated with vestibular dysfunction in the pre-diabetic patients.

Key words: pre-diabetic mellitus, vestibular dysfunction, caloric test

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