初诊2型糖尿病患者糖尿病肾病与幽门螺旋杆菌感染的关系

doi:10.3969/j.issn.1006-7795.2020.01.005

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (1): 27-30.doi: 10.3969/j.issn.1006-7795.2020.01.005

• 糖尿病的临床与基础研究 • 上一篇下一篇

初诊2型糖尿病患者糖尿病肾病与幽门螺旋杆菌感染的关系

李彬¹, 崔丽梅¹, 吕纳强², 严晔华¹, 郑晓敏¹, 陶静¹, 刘翠平¹

1. 北京市垂杨柳医院内分泌科, 北京 100022;
2. 中国医学科学院阜外医院特需医疗中心, 北京 100037

收稿日期:2019-12-12 出版日期:2020-02-21 发布日期:2020-02-13
通讯作者: 崔丽梅 E-mail:clm812@163.com
基金资助:
国家重点研发计划（2017YFC0909600），北京市科委2017科技计划课题（D171100002817005），北京市医院管理局临床医学发展专项经费资助（ZYLX201823）。

Relations between infected with Helicobacter pylori and diabetic nephropathy in the patients with newly-diagnosed type 2 diabetes mellitus

Li Bin¹, Cui Limei¹, Lyu Naqiang², Yan Yehua¹, Zheng Xiaomin¹, Tao Jing¹, Lui Cuiping¹

1. Department of Endocrinology, Beijing Chuiyangliu Hospital, Beijing 100022, China;
2. Department of Special Care Center, Fuwai Cardiovascular Diseases Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China

Received:2019-12-12 Online:2020-02-21 Published:2020-02-13
Supported by:
This study was supported by National K&D Program of China (2017YFC0909600), Science and Technology Plan of Beijing City (D171100002817005),Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201823).

摘要/Abstract

摘要： 目的探讨初诊2型糖尿病（type 2 diabetes mellitus，T2DM）患者糖尿病肾病（diabetic nephropathy，DN）发生风险与幽门螺旋杆菌（helicobacter pylori，HP）感染之间的关系。方法选择北京市垂杨柳医院内分泌科2014年5月至2018年5月就诊的初诊T2DM患者371例。根据尿微量白蛋白/尿肌酐（urinary microalbumin to creatine ratio，UACR）分为3组，DN0组（UACR男性<2.5 mg/mmol，女性<3.5 mg/mmol）为无糖尿病肾病组215例；DN1组（男性2.5 mg/mmol≤UACR < 30 mg/mmol，女性3.5 mg/mmol≤UACR < 30 mg/mmol）为DN微量蛋白尿组128例；DN2组（UACR≥30 mg/mmol）为DN临床蛋白尿组28例。结果单因素分析显示HP感染与DN微量蛋白尿有关联（OR=1.77，95%CI：1.103~2.851），但未发现HP感染阳性与DN临床蛋白尿有关。多因素Logistic回归分析结果显示，初诊2型糖尿病HP阳性者发生DN的风险是阴性者的2.52倍（OR=2.516，95%CI：1.305~4.849）。结论初诊的T2DM患者HP感染与DN有关系，HP感染可以增加T2DM患者发生DN的风险。

关键词: 2型糖尿病, 糖尿病肾病, 幽门螺旋杆菌, 危险因素

Abstract: Objective To study the relation between Helicobacter pylori(HP) infection and risk of diabetic nephropathy(DN) in the newly-diagnosed type 2 diabetes mellitus(T2DM) patients. Methods Totally 371 patients with the newly-diagnosed T2DM were enrolled between May 2014 and May 2018 at Department of Endocrinology, Beijing Chuiyangliu Hospital.According to urinary microalbumin to creatine ratio(UACR), these patients were divided into three groups:DN0 group (n=215), with UACR (male <2.5 mg/mmol and female<3.5 mg/mmol); DN1 group (n=128), with UACR (male 2.5 mg/mmol ≤ UACR < 30 mg/mmol, female 3.5 mg/mmol ≤ UACR < 30 mg/mmol); DN2 group(n=28), with UACR ≥ 30 mg/mmol.Results Single factor analysis showed that HP infection was associated with DN microalbuminuria (OR=1.77, 95% CI:1.103-2.851), but HP infection wasn't associated with DN clinical proteinuria.The Logistic regression analysis showed that the risk of DN was 2.52 fold higher in newly-diagnosed type 2 diabetic patients with positive HP than those with negative HP(OR=2.516, 95%CI:1.305-4.849).Conclusion HP infection is related to DN in newly-diagnosed T2DM patients. HP infection can increase the risk of DN in T2DM patients.

Key words: type 2 diabetes mellitus, diabetic nephropathy, Helicobacter pylori, risk factors

中图分类号:

R587

李彬, 崔丽梅, 吕纳强, 严晔华, 郑晓敏, 陶静, 刘翠平. 初诊2型糖尿病患者糖尿病肾病与幽门螺旋杆菌感染的关系[J]. 首都医科大学学报, 2020, 41(1): 27-30.

Li Bin, Cui Limei, Lyu Naqiang, Yan Yehua, Zheng Xiaomin, Tao Jing, Lui Cuiping. Relations between infected with Helicobacter pylori and diabetic nephropathy in the patients with newly-diagnosed type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2020, 41(1): 27-30.

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初诊2型糖尿病患者糖尿病肾病与幽门螺旋杆菌感染的关系

Relations between infected with Helicobacter pylori and diabetic nephropathy in the patients with newly-diagnosed type 2 diabetes mellitus

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