真皮内脂肪组织调控皮肤生理病理过程与机制的研究进展

doi:10.3969/j.issn.1006-7795.2020.06.006

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (6): 896-900.doi: 10.3969/j.issn.1006-7795.2020.06.006

真皮内脂肪组织调控皮肤生理病理过程与机制的研究进展

李沛霖¹, 崔磊^1,2*

1.首都医科大学附属北京世纪坛医院整形外科,北京 100038;
2.首都医科大学附属北京世纪坛医院中心实验室,北京 100038

收稿日期:2020-08-20 出版日期:2020-12-21 发布日期:2021-01-18
基金资助:
国家自然科学基金(81471798),首都医科大学附属北京世纪坛医院中心实验室建设经费(2019-JS04)。

The complex landscape of dermal white adipose tissue on skin physiology and pathology

Li Peilin¹, Cui lei^1,2*

1. Department of Plastic Surgery, Beijing Shijitan Hospital,Capital Medical University, Beijing 100038, China;
2. Department of Central Laboratory, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

Received:2020-08-20 Online:2020-12-21 Published:2021-01-18
Contact: * E-mail: cuilei8890@bjsjth.cn.
Supported by:
National Natural Science Foundation of China(81471798); Enhancement Funding of Laboratory of Center, Beijing Shijitan Hospital, Capital Medical University(2019-JS04).

摘要/Abstract

摘要： 真皮内脂肪组织(dermal white adipose tissue,dWAT)是位于真皮网状层正下方的一层白色脂肪组织。dWAT在皮肤的生理病理过程中发挥着重要的作用,具有调控毛囊生长周期、促进创面愈合、介导皮肤先天性免疫和对抗皮肤衰老的作用。其最新的研究成果更新并加深了我们对皮肤的认识,并有望成为皮肤损伤修复与疾病治疗的新靶点。本文就dWAT新的研究进展做一综述。

关键词: 真皮内脂肪组织, 毛囊周期, 创伤愈合, 固有免疫, 皮肤衰老

Abstract: The dermal white adipose tissue(dWAT)is defined as adipose tissue underlying the reticular dermis,which could modulates skin homeostasis. The studies on the mechanism have revealed that dermal adipose tissue played an essential role in maintenance of hair cycles, healing of cutaneous wounds, and antibacterial ability of innate immune and skin aging. These studies update and deepen our understanding of the complicated interaction between dWAT and skin. It opened a novel avenue to find new targets in the treatment of skin diseases and the intervention of skin aging. This paper reviewed the recent research on dWAT.

Key words: dermal white adipose tissue, hair follicle, wound healing, innate immune, skin aging

中图分类号:

李沛霖, 崔磊. 真皮内脂肪组织调控皮肤生理病理过程与机制的研究进展[J]. 首都医科大学学报, 2020, 41(6): 896-900.

Li Peilin, Cui lei. The complex landscape of dermal white adipose tissue on skin physiology and pathology[J]. Journal of Capital Medical University, 2020, 41(6): 896-900.

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真皮内脂肪组织调控皮肤生理病理过程与机制的研究进展

The complex landscape of dermal white adipose tissue on skin physiology and pathology

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