原发性闭角型青光眼合并视网膜色素变性的临床特征分析

doi:10.3969/j.issn.1006-7795.2022.06.020

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (6): 948-952.doi: 10.3969/j.issn.1006-7795.2022.06.020

原发性闭角型青光眼合并视网膜色素变性的临床特征分析

段晓明^*, 康梦田, 唐炘, 王涛

首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室北京市眼科研究所,北京 100730

收稿日期:2021-02-04 出版日期:2022-12-21 发布日期:2022-11-30
基金资助:
首都临床特色应用研究与成果推广(Z171100001017040)。

Analysis of clinical features of primary angle closure glaucoma with retinitis pigmentosa

Duan Xiaoming^*, Kang Mengtian, Tang Xin, Wang Tao

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University;Beijing Key Laboratory of Ophthalmology and Visual Sciences;Beijing Institute of Ophthalmology, Beijing 100730, China

Received:2021-02-04 Online:2022-12-21 Published:2022-11-30
Contact: ^*E-mail: xmduan_eye@163.com

摘要/Abstract

摘要： 目的分析原发性闭角型青光眼合并视网膜色素变性患者的临床特征。方法本研究纳入2013年4月至2017年4月于首都医科大学附属北京同仁医院眼科中心住院治疗的原发性闭角型青光眼(primary angle closure glaucoma ,PACG)合并视网膜色素变性(retinitis pigmentosa,RP)患者32例,和同期入院的不合并RP的PACG患者229例。根据青光眼类型将其分为4组,急性闭角型青光眼合并RP组(acute angle closure glaucoma with retinitis pigmentosa, AACG-RP)12例、慢性闭角型青光眼合并RP组(chronic angle closure glaucoma with retinitis pigmentosa, CACG-RP)20例、急性闭角型青光眼不合并RP组(AACG-non RP)94例、慢性闭角型青光眼不合并RP组(CACG-non RP)135例,比较4组患者的发病年龄和眼轴长度等参数。结果患者平均发病年龄AACG-RP组(39.00±12.07)岁、CACG-RP组(43.85±12.79)岁、AACG-non RP组(66.44±9.40)岁、CACG-non RP组(63.95±10.42)岁,4组之间差异有统计学意义(F=47.70,P<0.05)。患者平均眼轴长度AACG-RP组(21.31±1.37)mm、CACG-RP组(22.33±1.09)mm、AACG-non RP组(22.31±1.03)mm、CACG-non RP组(22.47±1.01)mm,4组之间差异有统计学意义(F=19.09,P<0.05)。结论原发性闭角型青光眼患者合并视网膜色素变性患者中,急性闭角型青光眼患者较慢性闭角型青光眼患者发病更早,眼轴更短。原发性闭角型青光眼合并视网膜色素变性患者,尤其是急性闭角型青光眼合并视网膜色素变性患者较无视网膜色素变性者发病年龄更早,且眼轴更短。

关键词: 原发性闭角型青光眼, 视网膜色素变性, 眼轴长度, 人口学特点

Abstract: Objective To investigate the clinical features of primary angle closure glaucoma (PACG) patients with retinitis pigmentosa (RP). Methods This study included 32 patients suffering from PACG combined with RP hospitalized in Beijing Tongren Hospital, Capital Medical University from April 2013 to April 2017, and 229 PACG patients without RP hospitalized in the same period.According to the type of glaucoma, patients were divided into 4 groups, 12 patients in acute angle closure glaucoma with RP group (AACG-RP), 20 patients in chronic angle closure glaucoma with RP group (CACG-RP), 94 patients in AACG-non RP group and 135 patients in CACG-non RP group.The age of onset and axial length (AL) were compared among these four groups. Results Mean age of onset was (39.00±12.07) years in AACG-RP group, (43.85±12.79) years in CACG-RP group, (66.44±9.40) years in AACG-non RP group and (63.95±10.42) years in CACG-non RP group.The difference between the four groups was statistically significant (F=47.70,P<0.05).The mean AL was (21.31±1.37) mm in AACG-RP group, (22.33±1.09) mm in CACG-RP group, (22.31±1.03) mm in AACG-non RP group and (22.47±1.01) mm in CACG-non RP group.The difference between the four groups was statistically significant (F=19.09,P<0.05). Conclusions In PACG patients combined with RP, AACG patients had earlier age of onset and shorter AL than CACG patients. PACG patients combined with RP had earlier age of onset and shorter AL than those without RP, especially those with AACG combined with RP.

Key words: primary angle closure glaucoma, retinitis pigmentosa, axial length, demographic factors

中图分类号:

段晓明, 康梦田, 唐炘, 王涛. 原发性闭角型青光眼合并视网膜色素变性的临床特征分析[J]. 首都医科大学学报, 2022, 43(6): 948-952.

Duan Xiaoming, Kang Mengtian, Tang Xin, Wang Tao. Analysis of clinical features of primary angle closure glaucoma with retinitis pigmentosa[J]. Journal of Capital Medical University, 2022, 43(6): 948-952.

参考文献

[1] Gartner S, Schlossman A. Retinitis pigmentosa associated with glaucoma[J]. Am J Ophthalmol, 1949, 32(10):1337-1350.
[2] Sayo A, Ueno S, Kominami T, et al. Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10－2 in patients with retinitis pigmentosa[J]. Sci Rep, 2017, 7(1): 16383.
[3] 田雪莲, 唐莉, 张鑫, 等. 原发性视网膜色素变性合并青光眼的临床特征[J]. 中华眼底病杂志, 2021, 37(6): 423－428.
[4] Meirelles S H S, Barreto A S, Buscacio E S, et al. Retinitis pigmentosa with concomitant essential iris atrophy and glaucoma-case report[J]. Clin Ophthalmol, 2015, 9: 2139－2145.
[5] Ko Y C, Liu C J, Hwang D K, et al. Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study[J]. PLoS One, 2014, 9(9): e107660.
[6] Xu J A, Ouyang Z K, Yang Y F, et al. Ocular biometry in primary angle-closure glaucoma associated with retinitis pigmentosa[J]. J Ophthalmol, 2017, 2017: 9164846.
[7] Weinreb R N, Aung T, Medeiros F A. The pathophysiology and treatment of glaucoma: a review[J]. JAMA, 2014, 311(18): 1901－1911.
[8] 梁之桥, 游舒棋, 张瑜, 等. 超声生物显微镜观察急性闭角型青光眼与慢性闭角型青光眼眼前节结构差异的对比研究[J]. 中华眼科杂志, 2021, 57(9): 672－678.
[9] Liu X, Li M, Zhong Y M, et al. Damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma[J]. Int J Ophthalmol, 2010, 3(2): 152－157.
[10] Song W L, Shan L, Cheng F, et al. Prevalence of glaucoma in a rural northern China adult population: a population-based survey in Kailu county, Inner Mongolia[J]. Ophthalmology, 2011, 118(10): 1982－1988.
[11] Liu L F, Liu X Y, Huang C K, et al. Associated factors of acute primary angle closure glaucoma in a sub-group of Chinese people: comparison between attack eyes and normal controls[J]. Sci Rep, 2017, 7(1): 14885.
[12] Lai J S, Liu D T, Tham C C, et al. Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study[J]. Hong Kong Med J, 2001, 7(2): 118－123.
[13] Liang Y B, Friedman D S, Zhou Q, et al. Prevalence and characteristics of primary angle-closure diseases in a rural adult Chinese population: the Handan Eye Study[J]. Invest Ophthalmol Vis Sci, 2011, 52(12): 8672－8679.
[14] George R, Paul P G, Baskaran M, et al. Ocular biometry in occludable angles and angle closure glaucoma: a population based survey[J]. Br J Ophthalmol, 2003, 87(4): 399－402.
[15] Ritch R, Chang B M, Liebmann J M. Angle closure in younger patients[J]. Ophthalmology, 2003, 110(10): 1880－1889.
[16] 胡婕, 江冰. 急性和慢性原发性闭角型青光眼患者眼部生物学特征[J]. 中南大学学报(医学版), 2014, 39(4): 333－337.
[17] Ghose S, Sachdev M S, Kumar H. Bilateral nanophthalmos, pigmentary retinal dystrophy, and angle closure glaucoma—a new syndrome?[J]. Br J Ophthalmol, 1985, 69(8): 624－628.
[18] MacKay C J, Shek M S, Carr R E, et al. Retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma. A new recessive syndrome[J]. Arch Ophthalmol, 1987, 105(3): 366－371.
[19] Badeeb O, Trope G, Musarella M. Primary angle closure glaucoma and retinitis pigmentosa[J]. Acta Ophthalmol (Copenh), 1993, 71(6): 727－732.
[20] Wang M, Lin H T, Bai Y J, et al. Clinical evidence in concurrence of retinitis pigmentosa and glaucoma[J]. Chin Med J (Engl), 2011, 124(8): 1270－1274.
[21] Ten Berge J C, Fazil Z, van den Born I, et al. Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age-related macular degeneration, glaucoma and cataract[J]. Acta Ophthalmol, 2019, 97(2): 185－192.

原发性闭角型青光眼合并视网膜色素变性的临床特征分析

Analysis of clinical features of primary angle closure glaucoma with retinitis pigmentosa

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

本文评价

[1]	王怀洲, 王宁利. 原发性闭角型青光眼发病机制与防治体系的建立及应用——2013年度国家科学技术进步二等奖[J]. 首都医科大学学报, 2014, 35(1): 6-9.
[2]	刘妍;魏文斌;赵明. 视网膜色素变性患者视觉电生理学检测指标分析[J]. 首都医科大学学报, 2010, 31(1): 44-47.