阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究

doi:10.3969/j.issn.1006-7795.2023.03.020

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (3): 487-496.doi: 10.3969/j.issn.1006-7795.2023.03.020

阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究

夏宁¹,聂秀红^1*,王美平²,冯志红¹,穆志静³,樊晓君¹

1.首都医科大学宣武医院呼吸与危重症医学科, 北京 100053；2.首都医科大学宣武医院重症医学科, 北京 100053；3.首都医科大学宣武医院内分泌科，北京 100053

收稿日期:2022-07-26 出版日期:2023-06-21 发布日期:2023-06-08
通讯作者: 聂秀红 E-mail:xiuhongnie@outlook.com

Association between sleep efficiency and diabetes mellitus in obstructive sleep apnea syndrome and primary snoring patients

Xia Ning¹, Nie Xiuhong^1*, Wang Meiping², Feng Zhihong¹, Mu Zhijing³, Fan Xiaojun¹

1.Department of Respiratory and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China；2.Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053，China；3.Department of Endocrinology, Xuanwu Hospital, Capital Medical University, Beijing 100053，China

Received:2022-07-26 Online:2023-06-21 Published:2023-06-08

摘要/Abstract

摘要： 目的分析睡眠效率在阻塞性睡眠呼吸暂停(obstructive sleep apnea syndrome, OSA)和单纯鼾症患者中与糖尿病(diabetes mellitus, DM)患病率的相关性。方法以2002年10月至2021年9月在首都医科大学宣武医院呼吸科睡眠医学中心接受睡眠监测的3 124例患者为研究对象。所有患者根据睡眠效率比例不同分为≥85%、80%~84.9%和<80%三个等级, 并以呼吸暂停低通气指数(apnea hypopnea index, AHI)≥5次/h将纳入患者分为OSA组及单纯鼾症组, 以多因素Logistic模型分析睡眠效率与DM之间的相关性。结果在OSA组患者中, 校正潜在混杂因素后, 与睡眠效率≥85%相比, 睡眠效率<80%者发生DM的概率明显升高(OR=1.563, 95%CI:1.005~2.431, P=0.047), 而在单纯鼾症组差异无统计学意义(OR=0.957, 95%CI: 0.509~1.799, P=0.891)。结论在OSA患者中，睡眠效率低的患者糖尿病的发生风险明显增加，而在单纯鼾症患者中差异无统计学意义。

关键词: 睡眠效率, 糖尿病, 阻塞性睡眠呼吸暂停

Abstract: Objective To investigate the association between sleep efficiency and diabetes mellitus (DM) in obstructive sleep apnea syndrome (OSA) and primary snoring patients. Methods A total of 3 124 patients who received sleep monitoring in the Sleep Medical Center of Xuanwu Hospital, Capital Medical University from October 2002 to September 2021 were retrospectively analyzed. Sleep efficiency was divided into grade 1 (≥85%), grade 2 (80%-84.9%), and grade 3 (<80%). All participants were divided into OSA group and simple snoring group with apnea hypopnea index (AHI)≥5 times/h. Multivariate Logistic regression models were utilized to investigate the association between sleep quality and diabetes mellitus. Results In OSA patients, after adjusting for potential confounding factors, compared with sleep efficiency ≥ 85%, the prevalence of DM in sleep efficiency < 80% group was significantly higher (OR=1.563, 95%CI:1.005-2.431, P=0.047), but there was no significant difference in primary snoring group (OR=0.957, 95%CI:0.509-1.799, P=0.891). Conclusion There is a significant correlation between poor sleep efficiency and the incidence of DM in OSA patients.

Key words: sleep efficiency, diabetes mellitus, obstructive sleep apnea syndrome

中图分类号:

R766

夏宁, 聂秀红, 王美平, 冯志红, 穆志静, 樊晓君. 阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究[J]. 首都医科大学学报, 2023, 44(3): 487-496.

Xia Ning, Nie Xiuhong, Wang Meiping, Feng Zhihong, Mu Zhijing, Fan Xiaojun. Association between sleep efficiency and diabetes mellitus in obstructive sleep apnea syndrome and primary snoring patients[J]. Journal of Capital Medical University, 2023, 44(3): 487-496.

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阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究

Association between sleep efficiency and diabetes mellitus in obstructive sleep apnea syndrome and primary snoring patients

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