关键词: Graves眼病, 活动期病变, 糖皮质激素, 细胞因子, 白细胞介素

Abstract: Objective To explore the correlation between the changes of serum cytokine in active Graves' ophthalmopathy (GO) patients before and after glucocorticoid therapy and efficacy of glucocorticoid therapy.Methods Twenty-eight patients diagnosed with GO in the Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University from January 2021 to January 2024 were selected. All patients were diagnosis as active GO patients (CAS≥3). Patients received regular weekly glucocorticoid weekly pulse therapy with a total dose of 4.5 g. The concentrations of 34 cytokines in serum were examined. Meanwhile, clinical indicators such as gender, age, liver and kidney function, thyroid function before and after treatment, and antibodies of all subjects were collected. Results The levels of interleukins (IL)（IL-1α, IL-1β, IL-1Rα, IL-2Rα, IL-6, IL-8, IL-18, IL-12p40 and IL-16）and cytokines including cutaneous T cell attraction chemokines（CTACK), monocyte chemoattractant protein-1（MCP-1）, macrophage migration inhibitory factor (MIF), stromal cell-derived factor 1α (SDF-1α), basic fibroblast growth factor（basic-FGF）, granulocyte colony-stimulating Factor (G-CSF), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in active GO patients after glucocorticoid treatment were significantly decreased compared with before treatment (P<0.05). Conclusion The levels of interleukins（IL-1α, IL-1β, IL-1Rα, IL-2Rα, IL-6, IL-8, IL-18, IL-12p40 and IL-16）and cytokines including CTACK, MCP-1, MIF, SDF-1α, basic-FGF、G-CSF, TNF-α and IFN-γ in active GO patients decreased significantly after glucocorticoid therapy, suggesting that these cytokines may be involved in the efficacy of glucocorticoid therapy for GO.

Key words: Graves' ophthalmopathy, active phase, glucocorticoid, cytokines, interleukin