非小细胞肺癌围手术期免疫治疗研究进展———新辅助免疫治疗进展

doi:10.3969/j.issn.1006-7795.2024.04.017

摘要/Abstract

摘要： 非小细胞肺癌（non-small cell lung cancer, NSCLC）有较高的发病率和病死率，使其治疗成为全球急需应对的重大健康挑战。随着免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）的引入，治疗NSCLC的新思路不断涌现，并且在晚期NSCLC患者中已显示出显著的生存获益。近年来，研究人员开始探索将ICIs引入新辅助治疗的可行性，并发现其在新辅助治疗中同样可为患者带来治疗获益。本文旨在综述近期关于ICIs在NSCLC新辅助治疗中的研究进展，重点讨论其对患者生存期、病理反应等方面的影响。这些研究成果有望为改善NSCLC患者的新辅助治疗效果提供新的策略和思路。

关键词: 非小细胞肺癌, 围手术期, 免疫治疗, 研究进展

Abstract: The treatment of non-small cell lung cancer (NSCLC) with a considerably high occurrence and lethality represents a significant global health challenge, which urgently needs to be addressed. With the introduction of immune checkpoint inhibitors (ICIs), new treatment avenues for NSCLC have emerged, showing significant survival benefits in patients with advanced NSCLC. In recent years, researchers have begun to explore the feasibility of incorporating ICIs into neoadjuvant therapy, finding that they also offer therapeutic benefits in this context. This article aims to review recent research progress on ICIs in the neoadjuvant treatment of NSCLC, focusing on their impact on patient survival, pathological response, and other aspects. These research findings shed light on new strategies and insights for improving the neoadjuvant treatment outcomes of NSCLC patients.

Key words: non-small cell lung cancer, perioperative, immunotherapy, research progress

中图分类号:

R734.2

郝卓鸿, 云铎, 张颖, 李卉惠, 林海珊, 崔永, 赵磊. 非小细胞肺癌围手术期免疫治疗研究进展———新辅助免疫治疗进展[J]. 首都医科大学学报, 2024, 45(4): 666-677.

Hao Zhuohong, Yun Duo, Zhang Ying, Li Huihui, Lin Haishan, Cui Yong, Zhao Lei. Advances in research of perioperative immunotherapy for non-small cell lung cancer—advances in neoadjuvant immunotherapy[J]. Journal of Capital Medical University, 2024, 45(4): 666-677.

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