关键词: 金黄色葡萄球菌, 脓疱疮, 金葡菌烫伤样皮肤综合征, 表皮剥脱毒素, 反向乳胶凝集试验

Abstract: Objective To study the correlation between dermatosis and the serotype of exfoliative toxins(ET),and identify the correlativity of the serotype to impetigo or staphylococcal scalded-skin syndrome(SSSS).Methods Sixty strains of Staphylococcal aureus(SA) isolated from patients were studied.Among them,15 strains were isolated from patients with bullous impetigo patients,15 strains from patients with nonbullous impetigo,and 30 patients with strains from SSSS.The reversed passive latex agglutination has been used to detect exfoliative toxin A and B.Results There were 51 exfoliative toxin producers detected by the EXT-RPLA,including 3 serotype A producers and 8 serotype B producers,and 40 double producers.Of the 15 isolates from the skin of patients with bullous impetigo,12 isolates were positive in terms of exfoliative toxin production,including 2 serotype A producers and 10 double producers,with no serotype B producer.Of the 15 isolates from the skin of patients with nonbullous impetigo,10 isolates were positive in terms of exfoliative toxin production,including 1 serotype A producer and 9 double producers,with no serotype B producer.On the other hand,of the thirty SA isolates from patients with SSSS,29 exfoliative toxin producers were detected with the EXT-RPLA,including 8 serotype B producers,21 double producers and with no serotype A producer.Conclusion ETA is correlated with impetigo and ETB is associated with generalized SSSS.ET-producing SA is the most common pathogenic bacteria in these two diseases.

Key words: Staphylococcus aureus(SA), impetigo, staphylococcal scalded skin syndrome(SSSS), exfoliative toxin(ET), reversed passive latex agglutination test(RPLA)