来曲唑联合资癸女贞胶囊对多囊卵巢综合征子宫内膜薄性不孕患者的疗效观察

doi:10.3969/j.issn.1006-7795.2025.04.008

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (4): 632-636.doi: 10.3969/j.issn.1006-7795.2025.04.008

• 更年期妇科内分泌与生育力保护 • 上一篇下一篇

来曲唑联合资癸女贞胶囊对多囊卵巢综合征子宫内膜薄性不孕患者的疗效观察

马郡¹，阮祥燕^1，2*，许仲婷¹，赵越¹，王月姣¹， Alfred O.Mueck^1，2

1.首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科，北京 100026;2.德国图宾根大学妇产医院妇女健康部与妇女健康研究中心，图宾根 D-72076

收稿日期:2025-01-17 出版日期:2025-08-21 发布日期:2025-08-29
通讯作者: 阮祥燕 E-mail:ruanxiangyan@ ccmu.edu.cn
基金资助:
妇幼健康研究会中医药治疗不孕不育研究项目（2018AMCHS011）。

Clinical efficacy of letrozole combined with Zi Gui Nv Zhen Capsules in patients with PCOS complicated by thin endometrium-induced infertility

Ma Jun¹,Ruan Xiangyan^1，2*, Xu Zhongting¹ , Zhao Yue¹ , Wang Yuejiao¹, Alfred O.Mueck^1，2

1.Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China;2.Department of Women's Health, Research Centre for Women's Health and University Women's Hospital of Tuebingen, University Hospitals of Tuebingen, Tuebingen D-72076, Germany

Received:2025-01-17 Online:2025-08-21 Published:2025-08-29
Supported by:
This study was supported by Association for Maternal and Child Health Studies（2018AMCHS011）.

摘要/Abstract

摘要： 目的探讨来曲唑联合资癸女贞胶囊对多囊卵巢综合征（polycystic ovary syndrome ，PCOS）子宫内膜薄性不孕患者的疗效。方法招募符合子宫内膜薄性不孕诊断（子宫内膜厚度<0.8 cm，且未避孕1年未孕）的PCOS患者140例,采用数字表法随机分配到对照组和试验组，治疗3个月经周期。对照组患者于月经第3天给予来曲唑2.5 mg/d，月经第8~10天给予戊酸雌二醇片2 mg/d，地屈孕酮序贯10 mg/d。试验组在对照组治疗的基础上给予资癸女贞胶囊治疗。在3周期的治疗期间，观察排卵当日子宫内膜厚度(endometrial thickness，EMT)、排卵率及累计妊娠率。结果试验组3个月经周期的排卵日子宫内膜厚度均显著高于对照组［(0.86±0.23) cm vs (0.71±0.15) cm；(0.83±0.26) cm vs (0.68±0.19) cm；(0.87±0.26) cm vs (0.71±0.11) cm］，试验组累计妊娠率显著高于对照组(44.3% vs 25.7%)。结论在基础治疗基础上，联合资癸女贞胶囊可增加PCOS子宫内膜薄性患者的子宫内膜厚度，提高PCOS患者的妊娠率。

关键词: 资癸女贞胶囊, 来曲唑, 多囊卵巢综合征, 子宫内膜薄, 不孕, 妊娠率

Abstract: Objective To investigate the curative effect of letrozole combined with Zi Gui Nv Zhen Capsules on patients with polycystic ovary syndrome (PCOS) complicated by thin endometrial infertility. Methods 140 patients with PCOS who met the diagnosis of endometrial thin infertility (endometrial thickness<0.8 cm and no pregnancy for 1 year without contraception) were recruited and randomly assigned to the control group and the experimental group for 3 cycles of treatment. The control group was given letrozole 2.5 mg/d on the 3rd day of menstruation, estradiol valerate 2 mg/d on the 8-10th day of menstruation, and dydrogesterone 10 mg/d in sequence. The experimental group was treated with Zi Gui Nv Zhen Capsules on the basis of the control group. During 3 cycles of treatment, endometrial thickness (EMT), ovulation rate and cumulative pregnancy rate on the day of ovulation were examined.Results The EMT of the experiment group was significantly higher than that of the control group on the ovulation day of three cycles ［(0.86±0.23) cm vs (0.71±0.15) cm；(0.83±0.26) cm vs (0.68±0.19)cm; (0.87±0.26) cm vs (0.71± 0.11) cm］, the cumulative pregnancy rate of experimental group was significantly higher than that of control group (44.3% vs 25.7%). There was no significant difference in ovulation rate between the two groups (P>0.05). Conclusion Our findings demonstrate that the combined use of Zi Gui Nv Zhen Capsule with basic conventional therapy significantly enhances endometrial thickness and improves pregnancy rates in PCOS patients with thin endometrium.

Key words: Zi Gui Nv Zhen Capsules, letrozole, polycystic ovary syndrome (PCOS), thin endometrium, infertility, pregnancy rate

中图分类号:

R711

马郡, 阮祥燕, 许仲婷, 赵越, 王月姣, Alfred O.Mueck. 来曲唑联合资癸女贞胶囊对多囊卵巢综合征子宫内膜薄性不孕患者的疗效观察[J]. 首都医科大学学报, 2025, 46(4): 632-636.

Ma Jun, Ruan Xiangyan, Xu Zhongting , Zhao Yue , Wang Yuejiao, Alfred O.Mueck, . Clinical efficacy of letrozole combined with Zi Gui Nv Zhen Capsules in patients with PCOS complicated by thin endometrium-induced infertility[J]. Journal of Capital Medical University, 2025, 46(4): 632-636.

参考文献

［1］Qiao J, Wang Y Y, Li X H, et al. A lancet commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China［J］. Lancet, 2021, 397(10293): 2497－2536.
［2］Kasius A, Smit J G, Torrance H L, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis［J］. Hum Reprod Update, 2014, 20(4): 530－541.
［3］Martins R S, Oliani A H, Oliani D V, et al. Continuous endometrial volumetric analysis for endometrial receptivity assessment on assisted reproductive technology cycles［J］. BMC Pregnancy Childbirth, 2020, 20(1): 663.
［4］Liu K E, Hartman M, Hartman A, et al. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40000 embryo transfers［J］. Hum Reprod, 2018, 33(10): 1883－1888.
［5］Teede H J, Tay C T, Laven J J E, et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome［J］. J Clin Endocrinol Metab, 2023, 108(10):2447－2469.
［6］黄羚, 江媚. 从肾－天癸－冲任－胞宫生殖轴论补肾活血法改善子宫内膜容受性低下［J］. 辽宁中医杂志, 2021, 48(10): 45－48.
［7］马郡, 阮祥燕, 许仲婷, 等. 资癸女贞胶囊对卵巢储备功能减退女性妊娠结局的影响［J］. 首都医科大学学报, 2023, 44(4): 540－543.
［8］Xu Z T, Ruan X Y, Xu X, et al. Efficacy and safety of Zi Gui Nv Zhen^® capsules used in TCM for fertility preservation in patients with diminished ovarian reserve［J］. Gynecol Endocrinol, 2022, 38(1): 73－77.
［9］中华医学会妇产科学分会内分泌学组及指南专家组. 多囊卵巢综合征中国诊疗指南［J］. 中华妇产科杂志, 2018, 53(1): 2－6.
［10］谢幸, 孔北华, 段涛. 妇产科学［M］.9版. 北京: 人民卫生出版社, 2018: 361－363.
［11］Siddiqui S, Mateen S, Ahmad R, et al. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)［J］. J Assist Reprod Genet, 2022, 39(11): 2439－2473.
［12］李红丽, 严烩利. 育龄期多囊卵巢综合征患者糖代谢与性激素及子宫内膜容受性的关系［J］. 实用临床医药杂志, 2024, 28 (10): 106-111.
［13］栾素娴, 马华刚, 赵文杰, 等. 不同剂量来曲唑在诱导排卵中对子宫内膜厚度影响的研究［J］. 中国计划生育学杂志, 2014, 22(1): 48－50.
［14］Li X, Luan T, Zhao C, et al. Effect of sildenafil citrate on treatment of infertility in women with a thin endometrium: a systematic review and meta-analysis［J］. J Int Med Res, 2020, 48(11): 300060520969584.
［15］Lv H N, Zhao J F, Jiang P P. Deciphering the endometrial niche of human thin endometrium at single-cell resolution［J］. Proc Natl Acad Sci U S A, 2022, 119(8): e2115912119.
［16］中国中西医结合学会妇产科专业委员会, 张明敏. 多囊卵巢综合征中西医结合诊治指南［J］. 中国中西医结合杂志, 2024, 44(1): 5－18.
［17］马堃, 李佳妮, 宫林娟, 等. 补肾促卵冲剂治疗多囊卵巢综合征导致不孕症临床及代谢机制研究［J］. 中国中药杂志, 2024, 49(8): 2006－2015.
［18］茹慧波, 马瑞红, 张丽敏, 等. 夏天教授治疗胚胎移植中薄型子宫内膜的经验撷菁［J］. 世界中医药, 2018, 13(1): 134－137.
［19］Ruan X Y, Xu Z T, Xu X, et al. A prospective study on the endometrium properties and the pregnancy rate of infertile women with thin endometrium receiving Fructus ligustri lucidi used in traditional Chinese medicine［J］. Gynecol Endocrinol, 2023, 39(1): 2249997.

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来曲唑联合资癸女贞胶囊对多囊卵巢综合征子宫内膜薄性不孕患者的疗效观察

Clinical efficacy of letrozole combined with Zi Gui Nv Zhen Capsules in patients with PCOS complicated by thin endometrium-induced infertility

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