噻环壬酯的电子轰击和电喷雾电离质谱分析

首都医科大学学报 ›› 2007, Vol. 28 ›› Issue (1): 61-63.

噻环壬酯的电子轰击和电喷雾电离质谱分析

徐艳霞¹, 王丽娟¹, 薛明¹, 阮金秀², 张振清², 刘克良²

1. 首都医科大学化学生物学与药学院药理学系;2. 军事医学科学院毒物药物研究所

收稿日期:2005-12-06 修回日期:1900-01-01 出版日期:2007-02-24 发布日期:2007-02-24
通讯作者: 薛明

Study on Thiencynonate by Electron Ionization and Electron Spray Ionization Mass Spectrometry

Xu Yanxia¹, Wang Lijuan¹, Xue Ming¹, Ruan Jinxiu², Zhang Zhenqing², Liu Keliang²

1. Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University;2. Institute of Pharmacology and Toxicology, The Academy of Military Medical Science

Received:2005-12-06 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24

摘要/Abstract

摘要： 目的对新型抗胆碱能M受体阻断剂结构类似物噻环壬酯(TC)进行深入研究。方法采用电子轰击质谱(EI-MS)、电喷雾电离质谱(ESI-MS)2种质谱技术分别对TC的结构和裂解途径进行实验。结果用ESI-MS获得m/z364[M+H]⁺、m/z156等质谱峰,用EI-MS获得m/z363[M]⁺、m/z138、m/z181、m/z154、m/z221等质谱峰,并解释了其中的主要特征碎片离子。结论 TC的EI-MS质谱和ESI-MS质谱中所出现的主要碎片离子峰都与其结构式中的主要骨架片段符合,所有的重要碎片峰均得到了满意的解释。

关键词: 质谱学, 噻环壬酯, 电子轰击质谱, 电喷雾电离质谱

Abstract: Objective Thiencynonate(TC) is a novel compound which is similar to anti-cholinergic drug developed by Institute of Pharmacology and Toxicology, used for the prevention and treatment of motion sickness or other disease caused by imbalance of function under movement stimulation and the pesticides poison of organic phosphorus. Methods For further study on it, the mass spectrometry techniques of electron ionization mass spectrometry(EI-MS) and electron spray ionization mass spectrometry(ESI-MS) were used for the elucidations of the structure and fragmentation pathway of TC. Results The results shows the molecular ion peak m/z 364[M+H]⁺, m/z156, were detected by ESI-MS; m/z363[M]⁺ and m/z138,m/z181 and m/z154, m/z221 were detected by EI-MS. Further more, the fragmentation pathway of TC was also explained. Conclusion The results provided a valuable information for the investigation and development of drugs similar to TC.

Key words: mass spectrometry, thiencynonate, electron ionization mass spectrometry, electron spray ionization mass spectrometry

中图分类号:

R962

徐艳霞;王丽娟;薛明;阮金秀;张振清;刘克良. 噻环壬酯的电子轰击和电喷雾电离质谱分析[J]. 首都医科大学学报, 2007, 28(1): 61-63.

Xu Yanxia;Wang Lijuan;Xue Ming;Ruan Jinxiu;Zhang Zhenqing;Liu Keliang. Study on Thiencynonate by Electron Ionization and Electron Spray Ionization Mass Spectrometry[J]. Journal of Capital Medical University, 2007, 28(1): 61-63.

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