新发每日持续性头痛18F-FDG PET脑代谢特点

doi:10. 3969/ j. issn. 1006-7795. 2024. 01. 003

首都医科大学学报 ›› 2024, Vol. 45 ›› Issue (1): 13-18.doi: 10. 3969/ j. issn. 1006-7795. 2024. 01. 003

• 核医学与分子影像辅助临床诊疗 • 上一篇下一篇

新发每日持续性头痛¹⁸F-FDG PET脑代谢特点

关皓琳¹，袁紫瑜^2,3，袁磊磊¹，陈谦¹，王永刚^2,3，艾林^1*

1.首都医科大学附属北京天坛医院核医学科，北京 100070；2.首都医科大学附属北京天坛医院头痛科，北京 100070；3.首都医科大学附属北京天坛医院神经病学中心，北京 100070

收稿日期:2023-10-18 出版日期:2024-02-21 发布日期:2024-03-21
通讯作者: 艾林 E-mail:ailin@bjtth.org
基金资助:
国家自然科学基金项目（32170752,81771143）。

Preliminary study on brain metabolic characteristics of ¹⁸F-FDG PET in new daily persistent headache

Guan Haolin¹， Yuan Ziyu^2,3， Yuan Leileⁱ¹， Chen Qian¹， Wang Yonggang^2,3， Ai Lin^1*

1.Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China；2.Department of Headache, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; 3.Neurology Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Received:2023-10-18 Online:2024-02-21 Published:2024-03-21
Supported by:
This study was supported by National Natural Science Foundation of China (32170752,81771143).

摘要/Abstract

摘要： 目的初步探讨氟-18-脱氧葡萄糖（¹⁸F-fluorodeoxyglucose， ¹⁸F-FDG ）正电子发射型计算机断层扫描显像（positron emission tomography，PET）在新发每日持续性头痛（new daily persistent headache, NDPH）患者各脑区的代谢特点。方法以2021年5月至2023年7月在首都医科大学附属北京天坛医院核医学科行 18F-FDG PET 检查的临床诊断为NDPH的患者为研究对象，应用Cortex ID（GE Healthcare）对PET图像进行分析，得到NDPH患者26个大脑区域的Z评分（Z-score）分布。应用Z评分分布来评估NDPH患者脑区的代谢特点。结果 NDPH患者在左、右前额内侧（P=0.004、P=0.009）、右侧扣带回后侧（P=0.003）、右侧楔前叶（P=0.003）、左侧运动整合区（P=0.036）、右侧扣带回前区（P=0.040）、左侧扣带回前区（P=0.037）、左侧扣带回后区（P=0.037）、右侧顶上小叶（P=0.002）、左侧顶上小叶（P=0.019）、左侧额叶前外侧（（P＜0.001）、左、右侧顶下小叶（P＜0.001）、左、右颞叶中线区（P＜0.001 ）和右侧颞叶外侧（P＜0.001）、脑桥（P＜0.001）等多个脑区表现出代谢降低。结论 ¹⁸F-FDG PET可以显示出NDPH患者不同脑区的代谢特点，为NDPH及其并发症的病理机制提供一定的代谢信息。

关键词: 新发每日持续性头痛, 慢性头痛, 正电子发射断层显像/计算机体层摄影术, ?? ¹⁸F-脱氧葡萄糖

Abstract: Objective To preliminarily study the value of fluorine-18 deoxyglucose (¹⁸F-FDG) positron emission tomography (PET) imaging in the metabolic characteristics of various brain regions of new daily persistent headache (NDPH) patients. Methods ¹⁸F-FDG PET images of patients with NDPH who underwent ¹⁸F-FDG PET examination at the Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University from May 2021 to July 2023 were collected retrospectively. Cortex ID (GE Healthcare) was used to analyze the PET images and to obtain the Z-score distribution of 26 brain regions of the NDPH patient group. The z-score distribution was applied to evaluate the metabolic characteristics of brain regions of NDPH patients.Results NDPH patients showed reduced metabolism in multiple brain regions such as left/right prefrontal medial region（P=0.004、P=0.009）, right posterior cingulate （P=0.003）, right precuneus （P=0.003）, left sensorimotor（P=0.036）, right anterior cingulate（P=0.040）, left anterior cingulate（P=0.037）, left posterior cingulate （P=0.037）, right parietal superior （P=0.002）, left parietal superior（P=0.019）, left prefrontal lateral （P＜0.001）, left/right parietal inferior（P＜0.001）, left/right temporal mesial （P＜0.001 ）, right temporal lateral （P＜0.001）and pons（P＜0.001）. Conclusion ¹⁸F-FDG PET can display metabolic characteristics in different brain regions of NDPH patients, which may provide metabolic information for the pathological mechanism of NDPH and its complications.

Key words: new daily persistent headache, chronic headache, positron emission tomography /computed tomography, ¹⁸F-fluorodeoxyglucose

中图分类号:

R741
R730.44

关皓琳, 袁紫瑜, 袁磊磊, 陈谦, 王永刚, 艾林. 新发每日持续性头痛¹⁸F-FDG PET脑代谢特点[J]. 首都医科大学学报, 2024, 45(1): 13-18.

Guan Haolin, Yuan Ziyu, Yuan Leilei, Chen Qian, Wang Yonggang, Ai Lin. Preliminary study on brain metabolic characteristics of ¹⁸F-FDG PET in new daily persistent headache[J]. Journal of Capital Medical University, 2024, 45(1): 13-18.

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链接本文: https://journal03.magtech.org.cn/Jweb_sdykdxxb/CN/10. 3969/ j. issn. 1006-7795. 2024. 01. 003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/CN/Y2024/V45/I1/13

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新发每日持续性头痛¹⁸F-FDG PET脑代谢特点

Preliminary study on brain metabolic characteristics of ¹⁸F-FDG PET in new daily persistent headache

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