首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (5): 639-642.doi: 10.3969/j.issn.1006-7795.2009.05.015

• 艾滋病基础研究及治疗 • 上一篇    下一篇

HIV-1潜伏库研究进展

焦艳梅, 吴昊   

  1. 首都医科大学附属北京佑安医院感染科
  • 收稿日期:2009-07-16 修回日期:1900-01-01 出版日期:2009-10-21 发布日期:2009-10-21
  • 通讯作者: 吴昊

Progresses in the Mechanism of HIV-1 Latency Formation

JIAO Yan-mei, WU Hao   

  1. Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University
  • Received:2009-07-16 Revised:1900-01-01 Online:2009-10-21 Published:2009-10-21

摘要: HIV-1在未经治疗的艾滋病患者体内虽可以持续复制,但也可潜伏在细胞内以逃避宿主的免疫清除,这一现象即病毒潜伏。病毒潜伏对抗病毒治疗带来了挑战,也引起人们的高度关注。本文对HIV-1病毒潜伏库的研究进展进行了综述。

关键词: 病毒DNA, 潜伏, HIV-1潜伏库

Abstract: Although HIV-1 can replicate continuously in untreated patients, they can also be hidden intracellularly to evade the host immune clearance, that is latent virus. As the viral latency is a challenge to antiviral treatment, great concern has arisen. This article reviews literature on the mechanism of HIV-1 latency formation.

Key words: virus DNA, latency, latency formation of HIV-1

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