过敏性疾病中辅助性T细胞的转录通路

doi:10.3969/j.issn.1006-7795.2009.06.010

首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (6): 770-774.doi: 10.3969/j.issn.1006-7795.2009.06.010

• 耳鼻咽喉头颈外科进展 • 上一篇下一篇

过敏性疾病中辅助性T细胞的转录通路

张媛¹, 王成硕², 张罗^1,2

1. 耳鼻咽喉头颈科学教育部重点实验室,北京市耳鼻咽喉科研究所;2. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科

收稿日期:2009-09-22 修回日期:1900-01-01 出版日期:2009-12-21 发布日期:2009-12-21
通讯作者: 张罗

Transcriptional Circuitries of T Helper cells in Allergic Diseases

Zhang Yuan¹, WANG Cheng-shuo², ZHANG Luo^1,2

1. Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology;2. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University

Received:2009-09-22 Revised:1900-01-01 Online:2009-12-21 Published:2009-12-21

摘要/Abstract

摘要：

目前对过敏性疾病的发病机制研究不仅局限于1型辅助性T细胞(T helper cells1,T_H1)和2型辅助性T细胞(T helper cells1,T_H2)的双重调节框架,新近发现的调节性T细胞(T regulatory cells,Treg)和促炎T_H17细胞亦受到重视。外周T细胞克隆的分化主要取决于相应转录调节因子主导的转录通路,包括T-bet(T_H1)、GATA-3(T_H2)、FOXP3(Treg)以及ROR-γτ/ROR-α(T_H17)。本文对不同T细胞亚群的转录调控机制及其在过敏性疾病中的作用做一综述。

关键词: 过敏性疾病, 辅助性T细胞, 转录通路

Abstract:

Originally interpreted within the framework of a binary T_H1/T_H2 paradigm, the knowledge of the pathogenesis of allergic diseases has broadened to incorporate the contribution of T regulatory cells and the newly described proinammatory T_H17 cell lineage. The commitment of peripheral T-cell clones to undergo differentiation into one of those lineages is shaped by transcriptional circuitries that center on key transcriptional regulators: T-box expressed in T cells(T_H1), GATA-3(T_H2), forkhead box p3(T regulatory cells), and retinoid-related orphan receptor gt/retinoid-related orphan receptor a(T_H17). The aim of this review is to elaborate on the transcriptional regulation mechanism of different T-cell subsets and their functions in allergic diseases.

Key words: allergic disease, T helper cell, transcriptional pathway

中图分类号:

R 392.8

张媛;王成硕;张罗. 过敏性疾病中辅助性T细胞的转录通路[J]. 首都医科大学学报, 2009, 30(6): 770-774.

Zhang Yuan;WANG Cheng-shuo;ZHANG Luo;. Transcriptional Circuitries of T Helper cells in Allergic Diseases[J]. Journal of Capital Medical University, 2009, 30(6): 770-774.

[1]	刘艳, 万岁桂. 滤泡辅助性T细胞与自身免疫性疾病的研究进展[J]. 首都医科大学学报, 2014, 35(4): 507-510.
[2]	段甦;张媛;张罗. 过敏性疾病的自然进程及干预[J]. 首都医科大学学报, 2011, 32(1): 55-59.

过敏性疾病中辅助性T细胞的转录通路

Transcriptional Circuitries of T Helper cells in Allergic Diseases

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