首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (5): 610-615.doi: 10.3969/j.issn.1006-7795.2012.05.011

• 艾滋病神经认知损害及疫苗学研究 • 上一篇    下一篇

中国HIV-1感染人群神经认知损害初步筛查

宋凤丽1, 张玉林2, 乔录新1, 丁渭1, 徐树莹1, 张彤2, 吴昊2, 陈德喜1   

  1. 1. 北京市肝病研究所,首都医科大学附属北京佑安医院, 北京 100069;2. 首都医科大学附属北京佑安医院感染科,北京 100069
  • 收稿日期:2012-07-19 修回日期:1900-01-01 出版日期:2012-10-21 发布日期:2012-10-21
  • 通讯作者: 陈德喜

An initial screening for HIV-1 associated neurocognitive disorders in HIV-1 infected patients in China.

SONG Feng-li1, ZHANG Yu-lin2, QIAO Lu-xin1, DING Wei1, XU Shu-ying1, ZHANG Tong2, WU Hao2, CHEN De-xi1   

  1. 1. Beijing Institute of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;2. Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
  • Received:2012-07-19 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

PDF

316

被引次数

13

摘要：

目的 初步调查中国人类免疫缺陷病毒-1(human immunodeficiency virus 1,HIV-1)感染者神经认知损害情况。方法通过国际HIV痴呆量表和神经心理评估,结合症状评分和临床相关资料对我国HIV-1感染人群HIV相关神经认知障碍(HIV-1 associated neurocognitive disorders, HAND)患病情况进行初步调查。结果 1我国HIV-1感染人群HAND患病率为37%;2认知障碍是主要症状,其次是行为异常;3脑脊液(cerebrospinal fluid, CSF)病毒载量与外周血病毒载量密切相关,但与HAND无关,同样HAND与CD4计数也无关。结论 结果显示中国HIV-1感染人群HAND患病率约为37%,以认知障碍症状为主;CSF与外周血病毒载量呈一致性变化,但是CD4计数和病毒载量不能作为诊断和预测HAND病情的指标,上述结果需要进一步的大样本调查予以证实。

关键词: 人类免疫缺陷病毒相关神经认知障碍, 患病率, 临床表现, 中国人群

Abstract:

Objective To initially screen for the HIV-1 associated neurocognitive disorders (HAND) in HIV-1 infected patients in China. Methods The International HIV Dementia Scale and a neuropsychological test battery were administered for screening and diagnosis of HAND in 134 HIV-1 infected patients in China. Subjective complaints, CD4 count and viral loads in both blood plasma and cerebrospinal fluid(CSF) were correlated with diagnosis of HAND. Results The prevalence of HAND in Chinese HIV-1 infected patients was 37%. The presence of HAND was associated with cognitive and behavior disorder complaints (4.9 and 4.1 fold higher than those without HAND, respectively). The level of viral load in CSF correlated with that in blood, but neither viral load (both in CSF and in blood) nor CD4 counts was found significantly different between HAND and non-HAND patients. Conclusion The prevalence of HAND in Chinese HIV-1 infected patients was 37%. Cognitive impairment is major complaint in HAND patients, followed by behavior disorder. None of viral load (viral load in CSF or in blood) and CD4 counts could predict the occurrence and development of HAND. Larger sample size, longitudinal observation and additional laboratory characterizations are needed to better characterize neurocognitive function among HIV-infected people in China.

Key words: HIV-1 associated neurocognitive disorders, prevalence, clinical manifestation, Chinese population

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