黄芪穴位注射对运动性疲劳大鼠TH1/TH2细胞因子的影响

doi:10.3969/j.issn.1006-7795.2012.05.016

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (5): 634-637.doi: 10.3969/j.issn.1006-7795.2012.05.016

黄芪穴位注射对运动性疲劳大鼠TH1/TH2细胞因子的影响

李君芳¹, 张秋霞², 赵晖², 张琪², 王海征², 姜明印³

1. 郑州大学体育学院, 郑州 450044;2. 首都医科大学中医药学院, 北京100069;3. 中国人民解放军陆军航空兵学院校医务室, 北京 101123

收稿日期:2012-05-14 修回日期:1900-01-01 出版日期:2012-10-21 发布日期:2012-10-21
通讯作者: 张秋霞

Effects of acupoint injection of Radix Astragali on Th1 and Th2 type cytokines in sport fatigue model rat

LI Jun-fang¹, ZHANG Qiu-xia², ZHAO Hui², ZHANG Qi², WANG Hai-zheng², JIANG Ming-yin³

1. Physical Education College of Zhengzhou University, Zhengzhou 450044, China;2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;3. School Clinic, Army Aviation Institution of PLA, Beijing 101123, China

Received:2012-05-14 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

摘要/Abstract

摘要： 目的通过检测血清中白细胞介素-2(interleukin-2,IL-2)、γ干扰素(interferon-γ,IFN-γ)、IL-4,IL-10的含量,分析黄芪穴位注射对运动型疲劳大鼠TH1/TH2细胞因子的影响。方法健康SD雄性大鼠分为:正常对照组8只;疲劳模型空白干预组8只;疲劳模型黄芪注射组8只;疲劳模型0.9%氯化钠注射液注射组8只。疲劳模型黄芪注射组予以足三里穴位注射黄芪注射液0.1 mL。疲劳模型0.9%氯化钠注射液组予以足三里穴位注射0.1 mL 0.9%氯化钠注射液。每天游泳后称量体质量。末次游泳结束后,穴位注射1 h后,予以水合氯醛麻醉,心脏取血后,检测血清中 IL-2、IFN-γ、IL-4、IL-10的含量。结果疲劳模型空白干预组血清IL-2及血清IFN-γ低于正常对照组;疲劳模型黄芪注射组的血清IL-2及血清IFN-γ高于疲劳模型空白干预组(P<0.01)。结论黄芪穴位注射可以减少运动性疲劳大鼠的体质量下降;可以调节运动性疲劳大鼠Th1/Th2细胞因子的平衡。

关键词: 黄芪, 穴位注射, 运动性疲劳, TH1/TH2细胞因子

Abstract: Objective To observe the effects of the acupoint injection of Radix Astragali Astragali on Th1 and Th2 type cytokines in Sport Fatigue Rats. Methods Totally 24 rats were divided into normal group, model group, acupoint injection of Radix Astragali group and acupoint injection of physiological saline group randomly, 8 rats in each group. The rats were injected with Radix Astragali and physiological saline in zusanli (ST36) acupoint respectively in acupoint injection of Radix Astragali group and acupoint injection of physiological saline group per-day after the swimming training. After the swimming training and the 10 days treatment, all the rats were injected with chloral hydrate for anesthesia. The blood was taken from each rat's heart and the contents of IL-2, IFN-γ, IL-4 and IL-10 in blood serum were examined. Results The serum levels of IL-2 and IFN-γ in model group decreased in comparison with those of normal group while The serum levels of IL-2 and IFN-γ in acupoint injection of Radix Astragali group increased obviously in comparison with those of model group(P<0.01). Conclusion Acupoint injection of Radix Astragali can prevent the rats from losing weight after swimming and can balance cytokines between type Th1 and Th2 cell.

Key words: Radix Astragali, acupoint injection, sport fatigue, Th1 and Th2 type cytokine

中图分类号:

R 254

李君芳;张秋霞;赵晖;张琪;王海征;姜明印. 黄芪穴位注射对运动性疲劳大鼠TH1/TH2细胞因子的影响[J]. 首都医科大学学报, 2012, 33(5): 634-637.

LI Jun-fang;ZHANG Qiu-xia;ZHAO Hui;ZHANG Qi;WANG Hai-zheng;JIANG Ming-yin. Effects of acupoint injection of Radix Astragali on Th1 and Th2 type cytokines in sport fatigue model rat[J]. Journal of Capital Medical University, 2012, 33(5): 634-637.

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黄芪穴位注射对运动性疲劳大鼠TH1/TH2细胞因子的影响

Effects of acupoint injection of Radix Astragali on Th1 and Th2 type cytokines in sport fatigue model rat

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