首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (3): 416-421.doi: 10.3969/j.issn.1006-7795.2013.03.018

• 临床研究 • 上一篇    下一篇

血管内皮生长因子及其受体表达水平下调增加垂体腺瘤卒中风险

贾旺1, 刘晓1, 鲁润春1, 贾桂军1, 倪明1, 孙静2, 徐志卿3   

  1. 1. 首都医科大学附属北京天坛医院神经外科, 北京100050;
    2. 首都医科大学基础医学院病理学系,北京 100069;
    3. 首都医科大学基础医学院神经生物学系, 北京 100069
  • 收稿日期:2013-05-12 出版日期:2013-06-21 发布日期:2013-06-17
  • 通讯作者: 贾旺, 徐志卿 E-mail:jwttyy@sina.com; E-mail: zhiqingx@ccmu.edu.cn
  • 基金资助:

    北京市优秀人才培养基金(22008ED0300400070)。

Down regulation of vascular endothelial growth factor (VEGF) and receptors related to apoplexy in human pituitary adenomas

JIA Wang1, LIU Xiao1, LU Runchun1, JIA Guijun1, NI Ming1, SUN Jing2, XU Zhiqing3   

  1. 1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
    2. Department of Pathology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;
    3. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2013-05-12 Online:2013-06-21 Published:2013-06-17
  • Supported by:

    This study was supported by the Beijing Talent Program(China) (22008ED0300400070).

摘要:

目的 探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体在垂体腺瘤中的表达与垂体腺瘤卒中之间的关系。方法 本实验运用实时定量核酸扩增检测系统(real-time quantitative PCR,QPCR)检测了166例垂体腺瘤标本中VEGF及其受体mRNA的表达,结合病理结果,免疫组织化学和临床资料特点分组进行统计学分析。结果 出现肿瘤卒中的无功能腺瘤中VEGF和VEGF-3的表达水平降低与肿瘤卒中有关(P<0.05);VEGF-1和VEGFR-2表达水平与肿瘤卒中无明显相关(P>0.05)。结论 无功能垂体腺瘤的VEGF和VEGFR-3的表达下降与垂体腺瘤卒中有关。

关键词: 血管内皮生长因子, 血管内皮生长因子受体, 垂体腺瘤, 肿瘤卒中

Abstract:

Objective To investigate the expression of vascular endothelial growth factor (VEGF) and its receptor in human pituitary adenoma apoplexy.Methods Pituitary adenomas from 166 patients were included in the study. Fresh pituitary adenomas were obtained immediately after surgery and processed for histological and molecular based analyses. Real-time quantitative PCR detection system (QPCR) were used to detect mRNA expression of VEGF and its receptor. Combined with the results of pathology, immunohistochemistry and clinical data were statistically analyzed for the characteristics of packet. Results The expression levels of VEGF and VEGF-3 were significantly lower in nonfunctional pituitary adenoma group with apoplexy, is closely linked to the tumor apoplexy (P<0.05); the expression level of VEGFR-1 and VEGFR-2 was not correlated with tumor apoplexy (P>0.05). Conclusion Down regulation of VEGF and VEGFR-3 in nonfunctional pituitary adenoma was associated with tumor apoplexy. VEGF and VEGFR-3 thus has an important predictive and prognostic value in patients with pituitary tumors.

Key words: vascular endothelial growth factor (VEGF), VEGF receptor, pituitary adenoma, apoplexy

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