首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (3): 446-449.doi: 10.3969/j.issn.1006-7795.2013.03.024

• 临床研究 • 上一篇    下一篇

替吉奥联合奥沙利铂治疗进展期胃癌的临床疗效观察

孔曼, 裴文仲, 杨建东   

  1. 首都医科大学潞河教学医院肿瘤内科,北京 101149
  • 收稿日期:2013-01-15 出版日期:2013-06-21 发布日期:2013-06-17
  • 通讯作者: 孔曼 E-mail:13611017375@139.com

Clinical observation of oxaliplatin combined with S1 capsule in the treatment of advanced gastric cancer

KONG Man, PEI Wenzhong, YANG Jiandong   

  1. Division of Oncology, The Luhe Teaching Hospital of the Capital Medical University, Beijing 101149, China
  • Received:2013-01-15 Online:2013-06-21 Published:2013-06-17

摘要:

目的 观察评价替吉奥胶囊(S-1)联合奥沙利铂治疗进展期胃癌的安全性和有效性。方法 52例入组患者,第1~14天替吉奥胶囊80 mg·m-2·d-1,分2次口服,第15~21 d停药,第1天奥沙利铂130 mg·m-2静脉滴注,21 d为1个周期。治疗4个周期后评价疗效和不良反应。结果 有效率为44.2%(23/52),临床获益率76.9%(40/52)。主要不良反应为骨髓抑制、胃肠道反应和周围神经毒性。结论 替吉奥胶囊联合奥沙利铂治疗进展期胃癌效果较好,不良反应可以耐受,其治疗方案和临床应用价值值得进一步研究。

关键词: 替吉奥胶囊, 奥沙利铂, 进展期胃癌, 化疗

Abstract:

Objective To investigate the safety and effectiveness of S-1 capsule combined with oxaliplatin in the treatment of advanced gastric cancer.Methods Fifty-two patients with advanced gastric cancer were treated with the chemotherapy: composed of S-1 capsule 80 mg·m-2·d-1, twice daily, oral, d1-14;oxaliplatin 130 mg·m-2, intravenous drip, d1. One treatment cycle covered 3 weeks. The effects and toxicities were evaluated after 4 cycles.Results The effective rate was 44.2% (23/52). The clinical beneficial response was 76.9%(40/52). The main side effects included myelosuppressio,gastrointestinal reactions and neurotoxicity.Conclusion S-1 capsule combined with oxaliplatin is effective in the treatment of advanced gastric cancer, and the toxicities can be tolerated. These results indicate that further clinical study and application are warranted.

Key words: S-1 capsule, oxaliplatin, advanced gastric cancer, chemotherapy

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