结直肠息肉发病危险因素分析

doi:10.3969/j.issn.1006-7795.2013.05.010

首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (5): 684-688.doi: 10.3969/j.issn.1006-7795.2013.05.010

结直肠息肉发病危险因素分析

李艳萍¹, 李骥¹, 盖小荣², 吴军³, 李文彬¹, 吴东¹, 姚方¹, 李景南¹

1. 中国医学科学院北京协和医学院北京协和医院消化内科, 北京 100730;
2. 中国医学科学院北京协和医学院北京协和医院体检中心, 北京 100730;
3. 山东省东营市胜利油田中心医院消化内科, 山东东营 257034

收稿日期:2013-03-05 出版日期:2013-10-21 发布日期:2013-10-22
通讯作者: 李景南 E-mail:lijn2008@126.com
基金资助:
北京市优秀人才资助项目(2009D003001000002)。

Analysis on risk factors of colorectal polyps

LI Yanping¹, LI Ji¹, GAI Xiaorong², WU Jun³, LI Wenbin¹, WU Dong¹, YAO Fang¹, LI Jingnan¹

1. Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China;
2. Department of Health Examination Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730 China;
3. Department of Gastroenterology, Central Hospital of Shengli Oilfield, Dongying 257034, Shandong Province, China

Received:2013-03-05 Online:2013-10-21 Published:2013-10-22
Supported by:
This study was supported by Excellent Person Project of Beijing(2009D003001000002).

摘要/Abstract

摘要：

目的探讨与结直肠息肉发病相关的危险因素。方法回顾性病例对照研究,选取在北京协和医院内镜中心行结肠镜检查发现结直肠息肉的病例,以健康体检人群行结肠镜未发现异常的病例为对照,给予问卷调查相关高危因素及分析息肉内镜下表现,采用SAS 9.2软件对数据进行统计学分析。结果本研究共纳入结直肠息肉患者106例,正常对照组383例。多因素Logistic回归分析年龄(OR=1.343, 95% CI:1.063~1.697)、癌症家族史(OR=3.013,95%CI:1.675~5.419)、摄食红肉(OR=1.650, 95%CI: 1.085~2.509)是发病的独立危险因素。息肉患者中,男性息肉瘤性检出率高于女性(P<0.05),随着年龄增大,腺瘤性息肉发生率显著增加(P<0.05)。结论年龄、癌症家族史、红肉摄入比例高是结直肠息肉发生的危险因素,摄入新鲜水果蔬菜为保护性因素。老年男性患者息肉瘤性率增加。通过高危因素问卷调查,有助于有针对性地开展结直肠肿瘤筛查。

关键词: 结直肠息肉, 结直肠癌, 危险因素, 筛查

Abstract:

Objective To investigate the risk factors that may be associated with colorectal polyps. Methods Patients who underwent complete colonoscopy at Peking Union Medical College Hospital endoscopy center between June 1, 2012 and May 31, 2013 were enrolled into this study. These patients were divided into polyps group and normal control group. Each case undertook the same questionnaire about their general situation and endoscopic polyps performance. The data were statistically analyzed by using SAS 9.2. Results Totally 106 colorectal polyps patients were enrolled into the polyps group and 383 normal persons were enrolled into control group. Multivariate logistic regression analyses were performed. Age (OR=1.343, 95%CI:1.063-1.697), family history of cancer (OR=3.013,95%CI:1.675-5.419) and high proportion of red meat intake (OR=1.650, 95%CI: 1.085-2.509) were independent risk factors for colorectal polyps. Adenomatous polyps was easier to be detected in male than in female (P<0.05) and the proportion of patients with adenomatous polyps increased with age (P<0.05). Conclusion Age, family history of cancer and high proportion of red meat intake are independent risk factors for colorectal polyps, while high proportion of fresh fruits and vegetables intake are protective factors. Elderly male patients may have increase risk to occur adenomatous polyps. Risk factors questionnaire is useful in screening for colorectal tumors.

Key words: colorectal polyps, colorectal cancer, risk factors, screening

中图分类号:

R574.6

李艳萍, 李骥, 盖小荣, 吴军, 李文彬, 吴东, 姚方, 李景南. 结直肠息肉发病危险因素分析[J]. 首都医科大学学报, 2013, 34(5): 684-688.

LI Yanping, LI Ji, GAI Xiaorong, WU Jun, LI Wenbin, WU Dong, YAO Fang, LI Jingnan. Analysis on risk factors of colorectal polyps[J]. Journal of Capital Medical University, 2013, 34(5): 684-688.

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结直肠息肉发病危险因素分析

Analysis on risk factors of colorectal polyps

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