伴有食管外症状的反流性食管炎患者的危险因素分析

doi:10.3969/j.issn.1006-7795.2022.01.022

摘要/Abstract

摘要： 目的通过对伴有和不伴有食管外(extra-esophageal,EE)症状的反流性食管炎(reflux esophagitis,RE)患者的一般人口学资料、生活方式、饮食习惯、合并症、目前用药、焦虑、抑郁等方面的比较,探讨EE症状发生的危险因素。方法选取2016年9月到2017年8月于首都医科大学宣武医院消化科门诊就诊,并于胃镜下明确诊断为RE的361例患者为研究对象,以是否存在EE症状,将其分为伴EE症状组和不伴EE症状组。采用问卷调查的方法对其进行一般人口学资料、生活方式、饮食习惯、合并症、目前用药、患者健康问卷-9(Patient Health Questionnaire-9,PHQ-9)抑郁量表、广泛性焦虑障碍-7(General Anxiety Disorder-7,GAD-7)焦虑量表、胃食管反流病量表(Gastroesophageal Reflux Disease Questionnaire,GerdQ)、反流症状指数评分等方面的调查。结果 361例RE患者中,伴EE症状者218例,以咽部异物感、反复咽喉痛及慢性咳嗽多见,分别占52.75%、46.79%和26.15%。单因素分析显示,两组患者在低教育水平、吸烟、便秘、高体质量指数(body mass index,BMI)、焦虑及抑郁方面,差异存在统计学意义(P<0.05)。多元Logistic回归分析显示,低教育水平(OR:1.646,95%CI:1.049~2.572,P<0.05)、吸烟(OR:2.488, 95%CI:2.047~3.281,P<0.01)、高BMI(OR:1.067, 95%CI:1.004~1.135,P<0.05)、抑郁(OR:1.062,95%CI:1.002~1.133,P<0.05)及焦虑(OR:1.061, 95%CI:1.001~1.131, P<0.05)是RE患者发生EE症状的危险因素。结论 RE患者以咽部异物感、反复咽喉痛及慢性咳嗽为主要EE症状;低教育水平、高BMI、吸烟、抑郁和焦虑是RE患者发生EE症状的危险因素。

关键词: 反流性食管炎, 食管外症状, 焦虑, 抑郁, 危险因素

Abstract: Objective To determine the risk factors of the reflux esophagitis (RE) with extra-esophageal(EE)symptoms by comparing general demographic information, lifestyle, eating habits, comorbidities, current medications, anxiety, depression of RE patients with and without EE symptoms. Methods The subjects of the study were seen in the Department of Gastroenterology, Xuanwu Hospital, Capital Medical University from September 2016 to August 2017 and were clearly diagnosed as RE under gastroscopy. There were 361 cases in total. They were divided into group with EE symptoms and group without EE symptoms. The patients were surveyed on General demographic information, lifestyle, eating habits, comorbidities, current medications, Patient Health Questionnaire-9(PHQ-9) Depression Scale, General Anxiety Disorder-7(GAD-7) Anxiety Scale, Gastroesophageal Reflux Disease Questionnaire(GerdQ)and Reflux Symptom Index(RSI). Results Among the 361 patients with RE, there were 218 patients with EE symptoms. Sensation of foreign body within the throat, recurrent sore throat and chronic cough were more common, accounting for 52.75%, 46.79% and 26.15% respectively. Univariate analysis showed that there were significant differences in low education level, smoking, constipation, high body mass index (BMI), anxiety, and depression (P<0.05) between two groups. Multivariate Logistic regression analysis identified that low education level (OR:1.646, 95%CI:1.049-2.572,P<0.05), smoking (OR:2.488,95%CI: 2.047-3.281, P<0.01), high BMI (OR:1.067, 95%CI: 1.004-1.135, P<0.05), depression (OR: 1.062, 95%CI: 1.002-1.133, P<0.05), anxiety(OR: 1.061, 95%CI: 1.001-1.131, P<0.05) were the risk factors of onset of EE symptoms in RE patients. Conclusion The main extra-esophageal symptoms of RE were sensation of foreign body within the throat and recurrent sore throat, chronic cough. Low education level, high BMI, smoking, depression and anxiety were risk factors of RE with extra-esophageal symptoms.

Key words: reflux esophagitis, extra-esophageal symptoms, depression, anxiety, risk factors

中图分类号:

王荣欣, 王晶, 胡水清. 伴有食管外症状的反流性食管炎患者的危险因素分析[J]. 首都医科大学学报, 2022, 43(1): 132-137.

Wang Rongxin, Wang Jing, Hu Shuiqing. Analysis of risk factors in patients with reflux esophagitis with extra-esophageal
symptoms[J]. Journal of Capital Medical University, 2022, 43(1): 132-137.

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