支气管哮喘合并OSA与冠心病发病率的相关性研究

doi:10.3969/j.issn.1006-7795.2022.01.023

摘要/Abstract

摘要： 目的回顾性分析支气管哮喘(以下简称哮喘)合并阻塞性睡眠呼吸暂停(obstructive sleep apnea syndrome, OSA)与冠状动脉粥样硬化性心脏病(以下简称冠心病)发病率的相关性。方法回顾性分析2002年10月至2020年9月在首都医科大学宣武医院呼吸科睡眠医学中心接受睡眠监测的3 152名患者。所有患者被分成4组,单纯鼾症组(n=1 335)、单纯支气管哮喘组(n=72)、单纯OSA组(n=1676)和哮喘合并OSA组(n=69),以多因素Logistic模型分析冠心病的独立相关因素。结果哮喘合并OSA组冠心病的发病率均明显高于单纯鼾症组、单纯OSA组及单纯哮喘组(OR＝13.389, 95%CI:7.930~22.607, P<0.01; OR=11.850, 95%CI: 7.116~19.733, P<0.01; OR=3.925,95%CI: 1.827~8.431, P<0.01)。校正年龄、性别、体质量指数(body mass index,BMI)及腹围等因素后差异仍有统计学意义 (OR=7.224, 95%CI: 3.989~13.083, P<0.01; OR=6.783, 95%CI: 3.811~12.073, P<0.01; OR=2.920, 95%CI: 1.240~6.878, P<0.01)。年龄≥55岁和腹围≥90 cm的患者中,哮喘合并OSA与冠心病的发生存在独立相关性(OR=5.464, 95%CI: 2.997~9.959, P<0.01; OR=4.630, 95%CI: 2.667~8.026, P<0.01)。结论哮喘合并OSA与冠心病的发生存在显著的相关性,尤其在老年及中心性肥胖人群中尤为显著。

关键词: 阻塞性睡眠呼吸暂停, 支气管哮喘, 冠状动脉粥样硬化性心脏病

Abstract: Objective The aim of this study was to investigate the influence of obstructive sleep apnea (OSA) with bronchial asthma (asthma) on the prevalence of coronary heart disease (CHD). Methods A total of 3 152 patients who received sleep monitoring in the Sleep Medical Center of Xuanwu Hospital, Capital Medical University from October 2002 to September 2020 were retrospectively analyzed. All patients were divided into four groups: simple snoring group (n=1 335), bronchial asthma group (n=72), OSA group (n=1676) and OSA with asthma group (n=69). The independent risk factors of coronary heart disease were analyzed by multivariate Logistic model. Results The incidence rate of CHD in asthma with OSA group was significantly higher than that in simple snoring group, simple OSA group and simple asthma group (OR=13.389, 95%CI:7.930-22.607, P<0.01; OR=11.850, 95%CI: 7.116-19.733, P<0.01; OR=3.925, 95%CI: 1.827-8.431, P<0.01). After adjusting for age, gender, BMI and abdominal circumference, there was still statistical significance (OR=7.224, 95% CI: 3.989 - 13.083, P<0.01; OR=6.783, 95%CI: 3.811-12.073, P<0.01; OR=2.920, 95%CI: 1.240-6.878, P<0.01).There was an independent correlation betweenasthma with OSA and CHD (OR=5.464, 95% CI: 2.997-9.959, P<0.01) in patients with age ≥ 55 years and abdominal circumference ≥ 90 cm(OR=4.630, 95%CI: 2.667-8.026, P<0.01). Conclusion There is a significant correlation between asthma with OSA and CHD, especially in the elderly and central obesity patients.

Key words: obstructive sleep apnea syndrome, asthma, coronary heart disease

中图分类号:

夏宁, 聂秀红, 王昊, 樊晓君. 支气管哮喘合并OSA与冠心病发病率的相关性研究[J]. 首都医科大学学报, 2022, 43(1): 138-142.

Xia Ning, Nie Xiuhong, Wang Hao, Fan Xiaojun. Association of OSA and asthma with the incidence rate of coronary heart disease[J]. Journal of Capital Medical University, 2022, 43(1): 138-142.

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