汉族人群ADIPOR1 rs7539542与冠状动脉粥样硬化性心脏病和2型糖尿病的关联分析

doi:10.3969/j.issn.1006-7795.2020.06.012

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (6): 935-942.doi: 10.3969/j.issn.1006-7795.2020.06.012

汉族人群ADIPOR1 rs7539542与冠状动脉粥样硬化性心脏病和2型糖尿病的关联分析

李响¹, 蒲连美¹, 阮杨², 李红¹, 金泽宁^2*

1.首都医科大学附属北京安贞医院急诊危重症中心,北京 100029;
2.首都医科大学附属北京天坛医院心内科,北京 100070

收稿日期:2019-08-09 出版日期:2020-12-21 发布日期:2021-01-18
基金资助:
国家自然科学基金(81570323),心血管疾病精准医学北京实验室(PXM2020_014226_000017_00377132_FCG)。

The relationship between ADIPOR1 rs7539542 and the susceptibility of coronary artery disease and type 2 diabetes in Han population

Li Xiang¹, Pu Lianmei¹, Ruan Yang², Li Hong¹, Jin Zening^2*

1. Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;
2. Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Received:2019-08-09 Online:2020-12-21 Published:2021-01-18
Contact: * E-mail:Jin_zening@163.com
Supported by:
National Natural Science Foundation of China (81570323); Beijing Lab for Cardiovascular Precision Medicine,Beijing, China(PXM2020_014226_000017_00377132_FCG).

摘要/Abstract

摘要： 目的分析ADIPOR1非内含子区域的单核苷酸多态性位点(single nucleotide polymorphisms,SNPs)是否增加冠状动脉粥样硬化性心脏病(以下简称冠心病)和2型糖尿病的易感风险。方法采用多病例-对照设计, 选取737 例行冠状动脉造影术,以及年龄、性别及体质量指数相匹配的研究对象:193例对照者(对照组)、142例2型糖尿病患者、203例冠心病患者及199例冠心病合并2型糖尿病患者。采用Sanger法对3个SNPs[位于3′非翻译区(untranslated regions,UTR):rs7539542 G>C 和 rs10581 C>T; 位于5′UTR:rs7517286 T>C]进行直接测序。结果 rs7539542 C等位基因不仅与冠心病(OR=1.67~2.34, P=2.87×10^-4~0.002) 、冠心病合并2型糖尿病(OR=1.52~2.08,P=0.003~0.016)的易感性相关,还增加2型糖尿病患者冠心病的易感风险(OR=1.58~2.90, P=0.002~0.038)。通过对血压进行亚组分析,发现上述关联仅分布于非高血压亚组。进一步在非高血压亚组进行基因与环境的交互作用分析,发现rs7539542 CC基因型与三酰甘油存在交互作用并增加冠心病(P=0.041, OR=5.006)和冠心病合并2型糖尿病(OR=5.381, P=0.04)易感风险。rs7517286 和rs10581与冠心病或2型糖尿病的易感性无明显关联(P>0.05)。结论位于ADIPOR 3′UTR的rs7539542多态性位点与冠心病的易感性独立相关,尤其对于非高血压患者。

关键词: 脂联素受体1, rs7539542, 冠状动脉粥样硬化性心脏病, 2型糖尿病, 关联

Abstract: Objective To analyze whether single nucleotide polymorphisms (SNPs) in non-intronic regions contributed to coronary artery disease (CAD) or type 2 diabetes (T2D) risk. Methods Seven hundred thirty-seven subjects who had undergone coronary arteriography were included in this multi-disease comparative study, with gender-, age-, and body mass index-matched among groups. There were 193 controls, 142 patients with T2D, 203 with CAD, and 199 with T2D and CAD. Three SNPs (rs7539542 G>C and rs10581 C>T at 3′ untranslated regions (UTR), rs7517286 T>C at 5′UTR) were genotyped by direct Sanger sequencing. Results rs7539542 C allele was positively associated with both CAD (OR=1.67-2.34, P=2.87×10^-4-0.002) and CAD with T2D (OR=1.52-2.08, P=0.003-0.016). Further analysis of case-case comparative results showed that rs7539542 C allele was associated with an increased risk of CAD in T2D patients (OR=1.58-2.90, P=0.002-0.038). Subgroup analyses of blood pressure level suggested that the above associations could only be found in the non-hypertension subgroup. For gene-environment interactions in the non-hypertension subgroup, rs7539542 CC genotype correlated with triglyceride level and contributed to a higher risk of CAD (OR=5.006, P=0.041) and CAD with T2D (OR=5.381, P=0.04). No significant association was found between rs7517286 or rs10581 variant and CAD or T2D(P＞0.05). Conclusion Our results suggest that rs7539542 at 3′UTR of ADIPOR1 is associated with CAD independently, especially in non-hypertension subjects.

Key words: adiponectin receptor 1, rs7539542, coronary artery disease, type 2 diabetes, association

中图分类号:

R541
R587

李响, 蒲连美, 阮杨, 李红, 金泽宁. 汉族人群ADIPOR1 rs7539542与冠状动脉粥样硬化性心脏病和2型糖尿病的关联分析[J]. 首都医科大学学报, 2020, 41(6): 935-942.

Li Xiang, Pu Lianmei, Ruan Yang, Li Hong, Jin Zening. The relationship between ADIPOR1 rs7539542 and the susceptibility of coronary artery disease and type 2 diabetes in Han population[J]. Journal of Capital Medical University, 2020, 41(6): 935-942.

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汉族人群ADIPOR1 rs7539542与冠状动脉粥样硬化性心脏病和2型糖尿病的关联分析

The relationship between ADIPOR1 rs7539542 and the susceptibility of coronary artery disease and type 2 diabetes in Han population

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