血浆氧化三甲胺及其前体物质浓度与冠状动脉粥样硬化性心脏病的关系

doi:10.3969/j.issn.1006-7795.2020.01.019

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (1): 99-102.doi: 10.3969/j.issn.1006-7795.2020.01.019

血浆氧化三甲胺及其前体物质浓度与冠状动脉粥样硬化性心脏病的关系

熊筱伟¹, 郭彩霞¹, 徐晓薇¹, 穆利英¹, 胡宏宇¹, 陈威¹, 陈步星²

1. 首都医科大学附属北京天坛医院心脏中心, 北京 100070;
2. 北京中医药大学附属东直门医院心血管科, 北京 101121

收稿日期:2019-08-07 出版日期:2020-02-21 发布日期:2020-02-13
通讯作者: 陈步星 E-mail:chbux@126.com
基金资助:
国家自然科学基金（81770349），首都卫生发展科研专项（2011-2004-04）。

Associations of plasma trimethylamine N-oxide and its precursors with coronary heart disease

Xiong Xiaowei¹, Guo Caixia¹, Xu Xiaowei¹, Mu Liying¹, Hu Hongyu¹, Chen Wei¹, Chen Buxing²

1. Cardiology Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;
2. Cardiology Department, Beijing Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 101121, China

Received:2019-08-07 Online:2020-02-21 Published:2020-02-13
Supported by:
This study was supported by National Natural Science Foundation of China (81770349),Capital Health Research and Development Special Founding(2011-2004-04).

摘要/Abstract

摘要： 目的探索血浆中氧化三甲胺（trimethylamine N-oxide，TMAO）及其前体物质的浓度与冠状动脉粥样硬化性心脏病（以下简称冠心病）（coronary heart disease，CHD）的关系。方法选取首都医科大学附属北京天坛医院心内科可疑CHD患者88例，根据冠状动脉造影结果将患者分为CHD组和对照组。利用高效液相法测患者血浆TMAO及其前体物质胆碱、肉碱、三甲胺乙内酯和三甲氨基丁内盐的浓度，分析两组患者血浆TMAO浓度及其前体物质与CHD的关系。结果 CHD组患者血浆TMAO浓度明显升高，差异有统计学意义[（6.20±3.57）μmol/L vs （3.90±2.26） μmol/L，P<0.05]；两组血浆中胆碱、肉碱、三甲胺乙内酯和三甲氨基丁内盐浓度差异均无统计学意义（P>0.05）。多因素Logistic回归分析，血浆TMAO浓度与CHD有关联（OR=1.35，P<0.05），血浆TMAO浓度升高，CHD的危险性增加。结论血浆中TMAO的浓度与CHD密切相关，而与TMAO前体物质浓度无显著相关性。

关键词: 冠状动脉粥样硬化性心脏病, 氧化三甲胺, 胆碱

Abstract: Objective To study the associations of plasma trimethylamine N-oxide (TMAO) and its precursors with coronary heart disease (CHD). Methods Patients with suspected CHD were enrolled in cardiology department of Beijing Tiantan Hospital, and divided into CHD and control groups according to angiography results. Plasma TMAO, choline, carnitine, betaine and butyrobetaine of all patients were measured by high-performance liquid chromatography, and the differences of plasma TMAO and its precursors between CHD and control patients were analyzed by statistical methods. Results The difference of plasma TMAO between CHD and control groups was significance[(6.20±3.57)μmol/L vs (3.90±2.26) μmol/L, P<0.05], but the differences of choline, carnitine, betaine and butyrobetaine between two groups were not significant (P>0.05). And plasma TMAO was still associated with CHD significantly in multivariate Logistic regression analysis (OR=1.35, P<0.05). Conclusion CHD was associated with plasma TMAO level significantly, but not its precursors.

Key words: coronary heart disease, trimethylamine N-oxide, choline

中图分类号:

R541.4

熊筱伟, 郭彩霞, 徐晓薇, 穆利英, 胡宏宇, 陈威, 陈步星. 血浆氧化三甲胺及其前体物质浓度与冠状动脉粥样硬化性心脏病的关系[J]. 首都医科大学学报, 2020, 41(1): 99-102.

Xiong Xiaowei, Guo Caixia, Xu Xiaowei, Mu Liying, Hu Hongyu, Chen Wei, Chen Buxing. Associations of plasma trimethylamine N-oxide and its precursors with coronary heart disease[J]. Journal of Capital Medical University, 2020, 41(1): 99-102.

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血浆氧化三甲胺及其前体物质浓度与冠状动脉粥样硬化性心脏病的关系

Associations of plasma trimethylamine N-oxide and its precursors with coronary heart disease

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