沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病并慢性心力衰竭的效果观察

doi:10.3969/j.issn.1006-7795.2020.01.022

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (1): 113-118.doi: 10.3969/j.issn.1006-7795.2020.01.022

沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病并慢性心力衰竭的效果观察

夏勇¹, 张建卿², 王少霞¹, 陈丹¹, 姬建民²

1. 河南科技大学第三附属医院(洛阳东方医院)心内科, 河南洛阳 471003;
2. 郑州市心血管病医院心外科, 郑州 465150

收稿日期:2019-06-12 出版日期:2020-02-21 发布日期:2020-02-13
通讯作者: 夏勇 E-mail:xiay99@sohu.com
基金资助:
河南省医学科技攻关计划项目（201403246）。

Effects of combined sacubitril/valsartan and metoprolol succinate sustained release tablets on patients who suffer from the coronary heart disease with chronic heart failure

Xia Yong¹, Zhang Jianqing², Wang Shaoxia¹, Chen Dan¹, Ji Jianmin²

1. Department of Cardiology, The Third Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China;
2. Department of Cardiovascular Surgery, Zhengzhou Cardiovascular Hospital, Zhengzhou 465150, China

Received:2019-06-12 Online:2020-02-21 Published:2020-02-13
Supported by:
This study was supported by Henan Medical Science and Technology Research Project (201403246).

摘要/Abstract

摘要： 目的探究沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病（以下简称冠心病）并慢性心力衰竭患者的效果。方法选取于2017年9月至2018年9月在河南科技大学第三附属医院和郑州市心血管病医院住院的冠心病并慢性心力衰竭患者为研究对象，按照入院顺序及年龄、病程、性别组间均衡的原则分为观察组（n=94）与对照组（n=93）。观察组给予沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗，对照组给予琥珀酸美托洛尔缓释片治疗。两组患者均连续治疗6个月，对比两组治疗效果及治疗前后心功能指标：舒张早期最大充盈速度（maximum early filling speed，E）、左心室射血分数（ejection fraction，EF）、舒张晚期最大充盈速度（maximum filling speed in late diastole，A）、E/A、血管内皮功能

关键词: 沙库巴曲缬沙坦, 琥珀酸美托洛尔缓释片, 冠状动脉粥样硬化性心脏病并慢性心力衰竭, 心功能

Abstract: Objective This paper was to explored the clinical efficacy of combined sacubitril/valsartan and metoprolol succinate sustained release tablets on patients who had the coronary heart disease with chronic heart failure. Methods This paper selected patients who suffered from the coronary heart disease with chronic heart failure in The Third Affiliated Hospital of Henan University of Science and Technology and Zhengzhou Cardiovascular Hospital from September 2017 to September 2018 as the samples. Based on intergroup equilibrium, the samples were divided into treatment group (n=94) and control group (n=93) uniformly by hospitalization date, age, disease course, and gender. Metoprolol succinate sustained release tablets were applied in control group, while sacubitril/valsartan and metoprolol succinate sustained release tablets were combined in treatment group. The therapy for patients in both group lasted for 6 months. This paper compared the clinical efficacy and cardiac function index:maximum early filling speed (E), left ventricular ejection fraction (EF), maximum filling speed in late diastole (A), E/A, vascular endothelial function[plasma endothelin (ET), calcitonin gene-related peptide (CGRP), nitric oxide (NO)], between two groups before and after the therapy. Results The clinical efficacy in treatment group was 93.62% which was significantly 78.49% higher than that in control group. After the therapy, E, EF, E/A, CGRP, NO in treatment group were higher than those in control group, while A and ET were lower in treatment group (P<0.05). Conclusion The therapy of combined sacubitril/valsartan and metoprolol succinate sustained release tablets had significant efficacy on coronary heart disease and heart failure by improving the cardiac function.

Key words: sacubitril /valsartan, metoprolol succinate sustained release tablets, coronary heart disease with chronic heart failure, cardiac function

中图分类号:

夏勇, 张建卿, 王少霞, 陈丹, 姬建民. 沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病并慢性心力衰竭的效果观察[J]. 首都医科大学学报, 2020, 41(1): 113-118.

Xia Yong, Zhang Jianqing, Wang Shaoxia, Chen Dan, Ji Jianmin. Effects of combined sacubitril/valsartan and metoprolol succinate sustained release tablets on patients who suffer from the coronary heart disease with chronic heart failure[J]. Journal of Capital Medical University, 2020, 41(1): 113-118.

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沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病并慢性心力衰竭的效果观察

Effects of combined sacubitril/valsartan and metoprolol succinate sustained release tablets on patients who suffer from the coronary heart disease with chronic heart failure

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