紫外二阶导数光谱法监测柠檬酸催化合成乙酰水杨酸

doi:10.3969/j.issn.1006-7795.2015.05.018

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (5): 757-760.doi: 10.3969/j.issn.1006-7795.2015.05.018

紫外二阶导数光谱法监测柠檬酸催化合成乙酰水杨酸

邵建群, 徐艳霞, 唐静成, 何深知, 张枫

首都医科大学化学生物学与药学院实验教学中心, 北京 100069

收稿日期:2014-12-15 出版日期:2015-10-21 发布日期:2015-10-20
基金资助:
北京市教委本科生培养-药学实验教学中心(PXM2014-014226-000103),首都医科大学2015年度校长基金(2015JYY28)。

Monitoring synthesis systems of acetylsalicylic acid with citric acid as the catalyst by second derivative spectrometry

Shao Jianqun, Xu Yanxia, Tang Jingcheng, He Shenzhi, Zhang Feng

Experimental Teaching Center, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China

Received:2014-12-15 Online:2015-10-21 Published:2015-10-20
Contact: 张枫 E-mail:zhangf@ccmu.edu.cn
Supported by:
This study was supported by Beijing Municipal Education Commission for Undergraduate Training of Pharmaceutical Experiment Teaching Center (PXM2014-014226-000103);2015 Principal Fund of Capital Medical University(2015JYY28).

摘要/Abstract

摘要： 目的采用紫外二阶导数光谱法监测柠檬酸催化合成乙酰水杨酸。方法选择二阶导数光谱在289 nm和308 nm处的吸光度值,分别建立乙酰水杨酸和水杨酸质量浓度与二阶导数值的标准工作曲线。在不同温度条件下,实时监测合成反应体系中乙酰水杨酸和水杨酸的质量浓度。结果反应温度为70 ℃、80 ℃、90 ℃和95 ℃,完成反应所需时间分别为80 min、50 min、20 min和15 min。结论紫外二阶导数光谱法,可以实现对乙酰水杨酸合成过程的监测和判断反应终点。

关键词: 乙酰水杨酸, 柠檬酸, 紫外光谱, 导数光谱

Abstract: Objective To establish a method for monitoring synthesis systems of acetylsalicylic acid with citric acid as the catalyst by second derivative spectrometry.Methods Respectively, standard work curve of acetyl salicylic acid and salicylic acid were established with second derivative value against concentration at the wavelengths of 289nm and 308nm. Under different temperatures, the real-time content of acetyl salicylic acid and salicylic acid in synthesis reaction system were monitored. Results When the reaction temperature is 70 ℃,80 ℃,90 ℃ and 95 ℃, the complete reaction times were about 80 min, 50 min, 20 min and 15 min individually. Conclusion The second derivative spectrometry method can be achieved on the monitoring and judging acetylsalicylic acid synthesis reaction endpoint.

Key words: acetyl salicylic acid, citric acid, ultraviolet spectrum, derivative spectrum

中图分类号:

R917
O657

邵建群, 徐艳霞, 唐静成, 何深知, 张枫. 紫外二阶导数光谱法监测柠檬酸催化合成乙酰水杨酸[J]. 首都医科大学学报, 2015, 36(5): 757-760.

Shao Jianqun, Xu Yanxia, Tang Jingcheng, He Shenzhi, Zhang Feng. Monitoring synthesis systems of acetylsalicylic acid with citric acid as the catalyst by second derivative spectrometry[J]. Journal of Capital Medical University, 2015, 36(5): 757-760.

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紫外二阶导数光谱法监测柠檬酸催化合成乙酰水杨酸

Monitoring synthesis systems of acetylsalicylic acid with citric acid as the catalyst by second derivative spectrometry

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