针灸治疗阿尔茨海默病机制研究进展

doi:10.3969/j.issn.1006-7795.2015.05.029

摘要/Abstract

摘要： 阿尔茨海默病是一种以记忆障碍为主的神经退行性疾病。针灸作为中国传统医学的重要组成部分在临床上早已经应用于阿尔茨海默病的治疗,但其机制并不明确。过去的几十年来,世界上若干国家的科学家致力于其治疗有效性及机制的研究。实验室研究表明,针灸可以抑制对神经系统有害的因素产生,促进具有保护作用的因素,从而发挥其对阿尔茨海默病的治疗效应。另一方面,随着功能磁共振的发展,研究人员发现针灸可以引发不同脑区的激活或者去激活以及调节脑区之间功能连接,而这种脑效应可能是针灸治疗阿尔茨海默病的重要机制之一。

关键词: 阿尔茨海默病, 针灸, 机制

Abstract: Alzheimer's disease(AD) is a progressive neurodegenerative disorder characterized by cognitive impairment. Acupuncture, an important component of Traditional Chinese Medicine, has been used in treatment of dementia for many years, but the mechanism is still unclear. In the past few decades, researchers in manyparts of the world have devoted to studying the essence of acupuncture treatment on AD. Conclusion drawn from experiments included that acupuncture plays a protective role through inhibiting harmful factors and promoting the beneficial ones. On the other side, using fMRI, researchers concluded that acupuncture could evoke activation or deactivation and modulate the functional connectivity between distinct brain regions, these effect of acupuncture on brain would be another important mechanism.

Key words: Alzheimer's disease, acupuncture, mechanism

中图分类号:

R741

李晖, 齐志刚, 李坤成. 针灸治疗阿尔茨海默病机制研究进展[J]. 首都医科大学学报, 2015, 36(5): 809-813.

Li Hui, Qi Zhigang, Li Kuncheng. Review of mechanisms of acupuncture in treatment of Alzheimer's disease[J]. Journal of Capital Medical University, 2015, 36(5): 809-813.

参考文献

[1] Ghezzi L, Scarpini E, Galimberti D. Disease-modifying drugs in Alzheimer's disease[J]. Drug Des Devel Ther, 2013, 7:1471-1478.
[2] Fassbender K, Masters C, Beyreuther K. Alzheimer's disease: molecular concepts and therapeutic targets[J]. Naturwissenschaften,2001,88(6):261-267.
[3] Liu Z, Niu W, Yang X, et al. Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus Jun in Alzheimer disease rats via olfactory system stimulation[J]. J Tradit Chin Med, 2013, 33(3):399-402.
[4] 徐强, 韩玉生, 姜国华, 等. 针刺对多因素AD 大鼠乙酞胆碱醋酶的超氧化物歧化酶的影响[J]. 针灸临床杂志, 2004, 20 (9): 45 -46.
[5] 王少锦, 康锁彬, 李爱英. 针刺拟痴呆大鼠对脑内自由基系统与胆碱能系统功能影响相关性的分析[J].针刺研究, 2004,29 (6):102 -106.
[6] 唐纯志, 赖新生, 杨君军, 等.电针对老年性痴呆大鼠脑内SOD、MDA、GSH-Px 影响的实验研究[J].陕西中医, 2005,26 (2):180 -181.
[7] Ding X, Yu J, Yu T, et al. Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10)[J]. Neurosci Lett,2006,399(1-2):11-16.
[8] Becker M, Lavie V, Solomon B. Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease[J]. Proc Natl Acad Sci USA,2007,104(5):1691-1696.
[9] Wang T, Liu C Z, Yu J C, et al. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus[J]. Physiol Behav, 2009, 96(1):155-161.
[10] Zhao C, Deng W, Gage F H. Mechanisms and functional implications of adult neurogenesis[J]. Cell,2008, 132(4):645-660.
[11] Stiles J, Jernigan T L. The basics of brain development[J]. Neuropsychol Rev, 2010, 20(4): 327-348.
[12] Lazarov O, Mattson M P, Peterson D A, et al. When neurogenesis encounters aging and disease[J]. Trends Neurosci, 2010,33(12):569-579.
[13] Cheng H, Yu J, Jiang Z, et al. Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice[J]. Neurosci Lette, 2008,432(2):111-116.
[14] Hwang I K, Chung J Y, Yoo D Y, et al. Effects of electroacupuncture at Zusanli and Baihui on brainderived neurotrophic factor and cyclic AMP response element-binding protein in the hippocampal dentate gyrus[J]. J Vet Med Sci,2010,72(11):1431-1436.
[15] Ding X, Yu J, Yu T, et al. Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10)[J]. Neuroscience Letters, 2006,399(1-2):11-16.
[16] Hunter C L, Bimonte-Nelson H A, Nelson M, et al. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen[J]. Neurobiol Aging, 2004,25(7):873-884.
[17] Veng L M, Granholm A C, Rose G M. Age-related sex differences in spatial learning and basal forebrain cholinergic neurons in F344 rats[J]. Physiol Behav, 2003,80(1):27-36.
[18] 董洪淘,白英.针刺对多因素AD模型海马ChE活性影响的实验研究[J].实用老年医学,2002,16:85-87.
[19] Zhao L, Shen P, Han Y, et al. Effects of acupuncture on glycometabolic enzymes in multi-infarct dementia rats[J]. Neurochem Res, 2011,36(5):693-700.
[20] 罗玳红,赖新生,唐纯志,等.电针治疗对老年性痴呆大鼠血清淀粉样蛋白及生长因子水平的影响[J].中国中医药信息杂志,2003:10:22-23.
[21] 石学敏,韩景献,李平,等.针刺对老化痴呆鼠脑兴奄性氨基酸水平影响的实验研究[J].中国针灸,1998,11:689-692.
[22] 阮怀珍,蔡文琴.医学神经生物学基础[M].西安:第四军医大学出版社,2006:213.
[23] Wang Z, Nie B, Li D, et al. Effect of acupuncture in mild cognitive impairment and alzheimer disease: a functional MRI study[J]. PLoS One, 2012, 7(8):e42730.
[24] Liang P P, Wang Z Q, Qian T Y, et al. Acupuncture stimulation of taichong (Liv3) and hegu (LI4) modulates the default mode network activity in alzheimer's disease[J]. Am J Alzheimers Dis Other Demen, 2014,29(8):739-748.
[25] Feng Y, Bai L, Ren Y, et al. Investigation of the largescale functional brain networks modulated by acupuncture[J]. Magn Reson Imaging, 2011,29(7):958-965.
[26] Hui K K, Marina O, Claunch J D, et al. Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects[J]. Brain Res, 2009, 1287:84-103.
[27] Zhou Y, Jin J. Effect of acupuncture given at the HT 7, ST 36, ST 40 and KI 3 acupoints on various parts of the brains of Alzheimer's disease patients[J]. Acupuncture Electrother Res, 2008,33(1-2):9-17.
[28] Liu P, Zhang Y, Zhou G Y, et al. Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study[J]. Neurosci Lett,2009, 462(3):183-187.