糖耐量正常人群OGTT 1 h血糖与胰岛素敏感性和胰岛β细胞功能的关系

doi:10.3969/j.issn.1006-7795.2017.04.020

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (4): 592-596.doi: 10.3969/j.issn.1006-7795.2017.04.020

糖耐量正常人群OGTT 1 h血糖与胰岛素敏感性和胰岛β细胞功能的关系

朱莉莉, 陈哲, 刘鑫, 于娜, 潘清蓉

首都医科大学附属北京朝阳医院内分泌科, 北京 100020

收稿日期:2017-03-20 出版日期:2017-07-21 发布日期:2017-07-20
通讯作者: 潘清蓉 E-mail:panqingrongcn@163.com
基金资助:
国家自然科学基金（81100587），北京市医院管理局"青苗"计划（QML20160304），首都医科大学本科生科研创新项目（73000737）

Relationships between OGTT 1-h plasma glucose levels and insulin sensitivity and pancreatic β cell function in subjects with normal glucose tolerance

Zhu Lili, Chen Zhe, Liu Xin, Yu Na, Pan Qingrong

Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2017-03-20 Online:2017-07-21 Published:2017-07-20
Supported by:
This study was supported by National Natural Science Foundation of China(81100587), Qingmiao Plan of Beijing Municipal Administration of Hospitals(QML20160304), Undergraduate Scientific Research and Innovation Program of Capital Medical University(73000737)

摘要/Abstract

摘要： 目的评价糖耐量正常（normal glucose tolerance，NGT）人群口服葡萄糖耐量试验（oral glucose tolerance test，OGTT）1 h血糖与胰岛素敏感性和胰岛β细胞功能的关系。方法收集101例NGT和76例糖耐量异常（impaired glucose tolerance，IGT）病人的临床资料；测定OGTT各时间点的血浆葡萄糖和胰岛素浓度；比较NGT 1 h血糖（1 hour postload plasma glucose，1-h PG）<8.6 mmol/L组、NGT 1-h PG ≥8.6 mmol/L组和IGT组的胰岛素敏感性和胰岛β细胞功能，分析OGTT 1-h PG与胰岛素敏感性和胰岛β细胞功能的关系。结果 NGT 1-h PG≥8.6 mmol/L组的空腹血糖、1-h PG、1-h 胰岛素及胰岛素敏感指数（homeostasis model assessment of insulin resistance，HOMA-IR）均显著高于NGT 1-h PG <8.6 mmol/L组；NGT 1-h PG≥8.6 mmol/L组的Matsuda指数、胰岛素分泌指数（ΔI₃₀/ΔG₃₀和ΔI₆₀/ΔG₆₀）均显著低于NGT 1-h PG<8.6 mmol/L组（P均<0.05）。但NGT 1-h PG≥8.6 mmol/L组的空腹血糖、空腹胰岛素、1-h PG、1-h 胰岛素、HOMA-IR、Matsuda指数、ΔI₃₀/ΔG₃₀和ΔI₆₀/ΔG₆₀与IGT组比较，差异无统计学意义（P均>0.05）。多元线性回归分析显示1-h PG与ΔI₃₀/ΔG_30、Matsuda 指数呈线性负相关。结论在NGT人群中，OGTT 1-h PG≥8.6 mmol/L人群胰岛素敏感性和胰岛β细胞功能低于1-h PG<8.6 mmol/L组，1-h PG与胰岛素敏感性和胰岛β细胞功能相关。提示在NGT人群中，1-h PG浓度可作为评价胰岛素敏感性和胰岛β细胞功能的简易指标。

关键词: OGTT 1-h血糖, 胰岛素敏感性, 胰岛β细胞功能

Abstract: Objective To evaluate the relationships between oral glucose tolerance test (OGTT)1h plasma glucose levels (1-h PG) and insulin sensitivity and pancreatic β cell function. Methods A total of 177 individuals without diabetes mellitus from Beijing Chaoyang Hospital were enrolled in the study from June 2015 to June 2016, all of them undertook a 75 g OGTT, and then we examined the correlation between 1-h PG and insulin sensitivity and pancreatic β cell function. Results In the normal glucose tolerance (NGT) 1-h≥ 8.6 mmol/L group, fasting plasma glucose,1-h PG,1-h insulin and steady-state homeostasis model assessment of insulin resistance (HOMA-IR) were significantly higher than that in the NGT 1-h<8.6 mmol/L group, but dynamic insulin sensitivity index (Matsuda index) and insulin secretion index (ΔI₃₀/ΔG₃₀ and ΔI₆₀/ΔG₆₀) were significantly lower than that in the NGT 1 h<8.6 mmol/L group. There were no differences in fasting plasma glucose, 1-h PG, 1-h insulin, HOMA-IR, Matsuda index, ΔI₃₀/ΔG₃₀ and ΔI₆₀/ΔG₆₀ between the NGT 1-h≥ 8.6 mmol/L group and IGT group. It showed that 1-h PG negatively correlated with ΔI₃₀/ΔG₃₀ and Matsuda index by using multivariable linear regression model.Conclusion Among individuals with NGT, those with 1-hour OGTT glucose ≥8.6 mmol/L show lower insulin sensitivity and impaired β cell function. OGTT 1-h PG is associated with insulin sensitivity and β cell function.

Key words: OGTT 1-h PG, insulin sensitivity, insulin β cell function

中图分类号:

R589.1

朱莉莉, 陈哲, 刘鑫, 于娜, 潘清蓉. 糖耐量正常人群OGTT 1 h血糖与胰岛素敏感性和胰岛β细胞功能的关系[J]. 首都医科大学学报, 2017, 38(4): 592-596.

Zhu Lili, Chen Zhe, Liu Xin, Yu Na, Pan Qingrong. Relationships between OGTT 1-h plasma glucose levels and insulin sensitivity and pancreatic β cell function in subjects with normal glucose tolerance[J]. Journal of Capital Medical University, 2017, 38(4): 592-596.

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糖耐量正常人群OGTT 1 h血糖与胰岛素敏感性和胰岛β细胞功能的关系

Relationships between OGTT 1-h plasma glucose levels and insulin sensitivity and pancreatic β cell function in subjects with normal glucose tolerance

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