生物钟的秘密——2017年诺贝尔生理学或医学奖简介

doi:10.3969/j.issn.1006-7795.2017.05.026

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (5): 765-769.doi: 10.3969/j.issn.1006-7795.2017.05.026

生物钟的秘密——2017年诺贝尔生理学或医学奖简介

李禹正¹, 张婷², 王晓民^2,3

1. 首都医科大学长学制临床医学专业, 北京 100069;
2. 首都医科大学基础医学院神经生物学系, 北京 100069;
3北京脑重大疾病研究院, 北京 100069

收稿日期:2017-10-11 出版日期:2017-09-21 发布日期:2017-10-18
通讯作者: 王晓民 E-mail:xmwang@ccmu.edu.cn

Discoveries of molecular mechanisms controlling the circadian rhythm-the 2017 Nobel Prize in Physiology or Medicine

Li Yuzheng¹, Zhang Ting², Wang Xiaomin^2,3

1. Clinical Medical Sciences, Capital Medical University, Beijing 100069, China;
2. Department of Neurobiology, Basic Medical Sciences, Capital Medical University, Beijing 100069, China;
3. Beijing Institute for Brain Disorders, Beijing 100069, China

Received:2017-10-11 Online:2017-09-21 Published:2017-10-18

摘要/Abstract

摘要： 北京时间2017年10月2日，瑞典卡罗琳斯卡医学院在斯德哥尔摩宣布，将2017年诺贝尔生理学或医学奖授予美国科学家Jeffrey C.Hall，Michael Rosbash以及Michael W.Young，以表彰他们在"生物节律的分子机制"方面的发现。

关键词: 2017诺贝尔生理学或医学奖, 生物钟, 昼夜节律

Abstract: In October 2, 2017, the Nobel Assembly at Karolinska Institute has decided to award the 2017 Nobel Prize in Physiology or Medicine jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm.

Key words: the 2017 Nobel Prize in Physiology or Medicine, biological clock, circadian rhythm

李禹正, 张婷, 王晓民. 生物钟的秘密——2017年诺贝尔生理学或医学奖简介[J]. 首都医科大学学报, 2017, 38(5): 765-769.

Li Yuzheng, Zhang Ting, Wang Xiaomin. Discoveries of molecular mechanisms controlling the circadian rhythm-the 2017 Nobel Prize in Physiology or Medicine[J]. Journal of Capital Medical University, 2017, 38(5): 765-769.

参考文献

[1] Scientific Background:Discoveries of Molecular Mechanisms Controlling the Circadian Rhythm[EB/OL].(2017-10-02)[2017-10-11] https://www.nobelprize.org/nobel_prizes/medicine/laureates/2017/advanced.html
[2] Smith R F, Konopka R J. Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila[J]. Mol Gen Genet, 1982, 185(1):30-36.
[3] Zehring W A, Wheeler D A, Reddy P, et al. P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster[J]. Cell, 1984, 39(2):369-376.
[4] Bargiello T A, Jackson F R, Young M W. Restoration of circadian behavioural rhythms by gene transfer in Drosophila[J]. Nature, 1984, 312(5996):752-754.
[5] Bargiello T A, Young M W. Molecular Genetics of a Biological Clock in Drosophila[J]. Proc Natl Acad Sci U S A, 1984, 81(7):2142-2146.
[6] Lorenz L J, Hall J C, Rosbash M. Expression of a Drosophila mRNA is under circadian clock control during pupation[J]. Development, 1989, 107(4):869-880.
[7] Siwicki K K, Eastman C, Petersen G, et al. Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system[J]. Neuron, 1988, 1(2):141-150.
[8] Hardin P E, Hall J C, Rosbash M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels[J]. Nature, 1990, 343(6258):536.
[9] Saez L, Young M W, Baylies M K, et al. Per—no link to gap junctions[J]. Nature, 1992, 360(6404):542.
[10] Vosshall L B, Price J L, Sehgal A, et al. Block in nuclear localization of period protein by a second clock mutation, timeless[J]. Science, 1994, 263(5153):1606-1609.
[11] Vitaterna M H, King D P, Chang A M, et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior[J]. Science, 1994, 264(5159):719.
[12] Price J L, Blau J, Rothenfluh A, et al. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation[J]. Cell, 1998, 94(1):83.
[13] Plautz J D, Straume M, Stanewsky R,et al. Quantitative analysis of Drosophila period gene transcription in living animals[J]. J Biol Rhythms, 1997,12(3):204-217.
[14] Stanewsky R, Jamison C F, Plautz J D, et al. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila[J]. EMBO J, 1997, 16(16):5006.
[15] Brandes C, Plautz J D, Stanewsky R, et al. Novel features of drosophila period Transcription revealed by real-time luciferase reporting[J]. Neuron, 1996, 16(4):687-692.
[16] Son G H, Chung S, Choe H K, et al. Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production[J]. Proc Natl Acad Sci U S A, 2008, 105(52):20970.
[17] Panda S. Circadian physiology of metabolism[J]. Science, 2016, 354(6315):1008.
[18] Gerstner J R, Yin J C. Circadian rhythms and memory formation[J]. Na Rev Neurosci, 2010, 11(8):577-588.
[19] Patke A, Murphy P J, Onat O E, et al. Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder[J]. Cell, 2017, 169(2):203.

生物钟的秘密——2017年诺贝尔生理学或医学奖简介

Discoveries of molecular mechanisms controlling the circadian rhythm-the 2017 Nobel Prize in Physiology or Medicine

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价

[1]	田俊萍, 王鸿, 王红霞, 赵性泉, 陈步星. 糖尿病和非糖尿病的缺血性卒中患者血压昼夜节律与预后的关系[J]. 首都医科大学学报, 2016, 37(1): 62-69.
[2]	丁晖;蔡彦宁;王玲玲;柴玉鑫;张燕莉;陈彪. 小鼠纹状体中神经递质相关基因表达的节律性波动[J]. 首都医科大学学报, 2009, 30(5): 580-583.
[3]	左晓虹;蔡彦宁;李宁;于顺;张燕莉;陈彪. 视交叉上核脑片与NIH/3T3成纤维细胞共培养模型的建立[J]. 首都医科大学学报, 2009, 30(5): 601-606.
[4]	左晓虹;蔡彦宁;于顺;刘姝;陈彪. MPTP对C57BL/6J小鼠脑时钟基因mPer1mRNA表达的影响[J]. 首都医科大学学报, 2009, 30(1): 76-79.
[5]	李静;华琦. 1023例急性心肌梗死患者发病时间特点分析[J]. 首都医科大学学报, 2008, 29(3): 354-356.
[6]	刘志;华琦;朱宏旭;李东宝. 睡眠呼吸暂停综合征合并高血压患者血压变化特点[J]. 首都医科大学学报, 2007, 28(4): 519-521.
[7]	左晓虹;陈彪;蔡彦宁;吴燕川;刘姝;谢淑;温玫. MPTP对C57小鼠纹状体DA释放节律的影响[J]. 首都医科大学学报, 2006, 27(1): 66-69.
[8]	杜凤和;徐秀英. 原发性高血压病人血压昼夜节律变化与心率变异的相关分析[J]. 首都医科大学学报, 1999, 20(1): 32-34.