中医体质类型与抗精神病药物不良反应的关系研究

doi:10.3969/j.issn.1006-7795.2018.02.010

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (2): 204-208.doi: 10.3969/j.issn.1006-7795.2018.02.010

• 精神分裂症基础和临床 • 上一篇下一篇

中医体质类型与抗精神病药物不良反应的关系研究

于迎^1,2, 庄红艳¹, 尹冬青¹, 杜渐³, 杨静⁴, 贾竑晓¹

1. 首都医科大学附属北京安定医院中西医结合研究室, 北京 100088;
2. 北京市大兴区精神病医院二科, 北京 102600;
3. 中国中医科学院中医临床基础医学研究所, 北京 100700;
4. 中国中医科学院医学实验中心, 北京 100700

收稿日期:2017-01-26 出版日期:2018-03-21 发布日期:2018-04-14
通讯作者: 贾竑晓 E-mail:jhxlj@ccmu.edu.com
基金资助:
北京市自然科学基金（7152069），北京市科委首都临床特色应用研究专项（Z151100004015061）。

Relationship between Traditional Chinese Medicine constitution classifications and the side effects of antipsychotic drugs

Yu Ying^1,2, Zhuang Hongyan¹, Yin Dongqing¹, Du Jian³, Yang Jing⁴, Jia Hongxiao¹

1. Chinese Medicine Research Center, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
2. The Second Department of Psychiatry, Beijing Daxing District Psychiatric Hospital, Beijing 102600, China;
3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences, Beijing 100700, China;
4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2017-01-26 Online:2018-03-21 Published:2018-04-14
Supported by:
This study was supported by Natural Science Foundation of Beijing (7152069), Clinical Characteristics Program of Beijing Municipal Science and Technology Commission (Z151100004015061).

摘要/Abstract

摘要： 目的研究中医体质类型与抗精神病药物不良反应之间的关系。方法通过选取首都医科大学附属北京安定医院住院患者作为研究对象，采用不良反应量表（Treatment Emergent Symptom Scale，TESS）评定抗精神病药物不良反应的严重程度。依据TESS评分，将住院治疗过程中接受抗精神病药物治疗后不良反应较重的119例患者作为研究组，应用等效剂量抗精神病药物治疗不良反应较轻的114例精神病患者作为对照组，采用标准化的9种中医体质量表调查法进行中医体质辨识。结果对照组与研究组的不同体质总体分布上差异有统计学意义（χ²=16.68，P<0.05）；血瘀质、气郁质在研究组中的分布比率明显多于对照组（χ²=4.56、4.24，P<0.05）；血瘀质、气郁质与TESS总分正相关且有统计学意义（r=0.25、0.29，P<0.01）；血瘀质与TESS心血管系统分量表得分正相关且有统计学意义（r=0.31，P<0.01）；气郁质与TESS自主神经系统分量表得分正相关且有统计学意义（r=0.214，P<0.05）。结论接受抗精神病药物治疗的患者中，血瘀质、气郁质两种体质的人更容易出现药物不良反应。而血瘀质的人更容易出现心血管系统不良反应，气郁质的人更容易出现自主神经系统不良反应。

关键词: 抗精神病药物, 药物不良反应, 中医体质

Abstract: Objective To study the relationship between Traditional Chinese Medicine (TCM) constitution classifications and the side effects of antipsychotic drugs. Methods Totally 233 patients of Beijing Anding Hospital of Capital Medical University treated with equivalent doses of antipsychotics were divided into research group and control group,119 cases with severe side effects of antipsychotic drugs were set as research group and 114 cases with gentle ones were set as control group. The nine standardized TCM Constitution Questionnaire survey methods were used to carry out the TCM constitution identification. Treatment Emergent Symptom Scale (TESS) was used to assess the severity of the side effects of antipsychotic drugs. Results There were the difference between research group and control group in the distribution of constitution in TCM(χ²=16.68,P<0.05);The distribution ratios of the patients with the Blood-stasis constitution and the Qi-depression constitution in research group were greater than that in control group(χ²=4.56,4.24,P<0.05). There was positive correlation with the patients with the blood-stasis constitution and the qi-depression constitution and aggregate score of TESS with statistically significance (r=0.25,0.29,P<0.01). The patients with the blood-stasis constitution and the cardiovascular system subscale scores from TESS showed positive correlation,with statistically significance (r=0.31,P<0.01). The patients with the qi-depression constitution and the autonomic nerve subscale scores from TESS showed positive correlation,with statistically significance (r=0.214,P<0.05). Conclusion The patients with blood-stasis constitution and the qi-depression constitution were more likely to experience side effect:those with the blood-stasis constitution are more likely to have the side effects of cardiovascular system and those with the qi-depression constitution were more likely to have the side effects of autonomic nervous system.

Key words: antipsychotic drugs, side effects, constitution in Traditional Chinese Medicine

中图分类号:

R277.7

于迎, 庄红艳, 尹冬青, 杜渐, 杨静, 贾竑晓. 中医体质类型与抗精神病药物不良反应的关系研究[J]. 首都医科大学学报, 2018, 39(2): 204-208.

Yu Ying, Zhuang Hongyan, Yin Dongqing, Du Jian, Yang Jing, Jia Hongxiao. Relationship between Traditional Chinese Medicine constitution classifications and the side effects of antipsychotic drugs[J]. Journal of Capital Medical University, 2018, 39(2): 204-208.

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中医体质类型与抗精神病药物不良反应的关系研究

Relationship between Traditional Chinese Medicine constitution classifications and the side effects of antipsychotic drugs

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