5-氨基酮戊酸光动力学诊断腹膜转移癌的研究进展

doi:10.3969/j.issn.1006-7795.2018.03.029

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (3): 469-475.doi: 10.3969/j.issn.1006-7795.2018.03.029

5-氨基酮戊酸光动力学诊断腹膜转移癌的研究进展

姬忠贺¹, 刘洋², Yutaka Yonemura^2,3, 李雁¹

1. 首都医科大学附属北京世纪坛医院腹膜肿瘤外科, 北京 100038;
2. Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan;
3. NPO Organization to Support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan

收稿日期:2017-05-15 出版日期:2018-05-21 发布日期:2018-06-11
通讯作者: 李雁 E-mail:liyansd2@163.com
基金资助:
北京市自然科学基金（7172108），首都临床特色应用研究与成果推广项目（Z161100000516077），首都医科大学附属北京世纪坛医院重点学科建设项目（2016FMZLWK）。

Research progress on photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)

Ji Zhonghe¹, Liu Yang², Yutaka Yonemura^2,3, Li Yan¹

1. Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
2. Peritoneal Surface Malignancy Center, KishiwadaTokushukai Hospital, 4-27-1 Kamori-Cho, Kishiwada City, Osaka 596-8522, Japan;
3. NPO Organization to support Peritoneal Surface Malignancy Treatment, 510 Fukushima-Cho, Shimogyou-Ku, Kyoto 600-8189, Japan

Received:2017-05-15 Online:2018-05-21 Published:2018-06-11
Supported by:
This study was supported by Natural Science Foundation of Beijing (7172108), Beijing Capital Characteristic Clinical Medicine Development Project (Z161100000516077), Key Discipline Development Fund of Beijing Shijitan Hospital, Capital Medical University (2016FMZLWK).

摘要/Abstract

摘要： 腹膜转移（peritoneal metastasis，PM）一直被视作癌症的终末阶段。20世纪90年代早期，外科肿瘤学界发展了细胞减灭术（cytoreductive surgery，CRS）加腹腔热灌注化学药物治疗（hyperthermic intraperitoneal chemotherapy，HIPEC）的综合治疗策略，可延长部分经谨慎选择的PM患者生存期。细胞减灭程度（completeness of cytoreduction，CCR）是该综合治疗后最重要的独立生存预测因子。然而，现行的手术技术容易遗漏肉眼难以发现的隐匿部位PM或微小癌灶，PM仍是常规CRS术后主要的复发形式。因此，近年来，光动力学诊断（photodynamic diagnosis，PDD）方法逐渐发展，并用于检测PM。本综述旨在总结5-氨基酮戊酸（5-aminolevulinic acid，5-ALA） PDD技术在PM中的应用进展。

关键词: 氨基酮戊酸, 光动力学诊断, 腹膜表面恶性肿瘤, PEPT1, ABCG2, 亚铁螯合酶

Abstract: Peritoneal metastasis (PM) has long been regarded as the terminal stage or cancer spreading. Since the 1990s, an integrated treatment strategy combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been gradually developed by the surgical oncology community, and has definitely improved the survival in selected patients with PM. In such comprehensive treatment strategy, completeness of cytoreduction (CCR) is the most important independent prognostic factor for survival benefit. The current CRS technique, however, is inadequate to identify the minute tumor nodules hidden at less accessible sites in the abdomen and pelvis. Thus PM still accounts for the most frequent form of cancer recurrence after CRS+HIPEC. There is an urgent need to develop sharper techniques to identify the minute PM nodules. Among the emerging technologies, photodynamic diagnosis (PDD) attracts the increasing attention for PM diagnosis. This review summarizes the application of 5-aminolevulinic acid (5-ALA) -based PDD for the diagnosis and treatment of PM.

Key words: 5-aminolevulinic acid, photodynamic diagnosis, peritoneal surface malignancy, PEPT1, ABCG2, ferrochelatase

中图分类号:

R735.5

姬忠贺, 刘洋, Yutaka Yonemura, 李雁. 5-氨基酮戊酸光动力学诊断腹膜转移癌的研究进展[J]. 首都医科大学学报, 2018, 39(3): 469-475.

Ji Zhonghe, Liu Yang, Yutaka Yonemura, Li Yan. Research progress on photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)[J]. Journal of Capital Medical University, 2018, 39(3): 469-475.

参考文献

[1] Li Y, Zhou Y F, Liang H, et al. Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies[J]. World J Gastroenterol, 2016, 22(30):6906-6916.
[2] Yonemura Y, Canbay E, Li Y, et al. A comprehensive treatment for peritoneal metastases from gastric cancer with curative intent[J]. Eur J Surg Oncol, 2016, 42(8):1123-1131.
[3] Yan T D, Black D, Savady R, et al. Systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal carcinoma[J]. J Clin Oncol, 2006, 24(24):4011-4019.
[4] Liu Y, Endo Y, Fujita T, et al. Cytoreductive surgery under aminolevulinic acid-mediated photodynamic diagnosis plus hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from ovarian cancer and primary peritoneal carcinoma:results of a phase I trial[J]. Ann Surg Oncol, 2014, 21(13):4256-4262.
[5] Yonemura Y, Endo Y, Canbay E, et al. Photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)[J]. Cancers (Basel), 2017, 9(3):23.
[6] Kaneko S, Kaneko S. Fluorescence-guided resection of malignant glioma with 5-ALA[J]. Int J Biomed Imaging, 2016, 2016:6135293.
[7] Hagiya Y, Fukuhara H, Matsumoto K, et al. Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer[J]. Photodiagnosis Photodyn Ther, 2013, 10(3):288-295.
[8] Yonemura Y. Selection of patients by membrane transporter expressions for aminolevulinic acid (ALA)-guided photodynamic detection of peritoneal metastases[J].Int J Sci, 2015, 4(9):66-77.
[9] Hagiya Y, Endo Y, Yonemura Y, et al. Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro[J]. Photodiagnosis Photodyn Ther,2012, 9(3):204-214.
[10] Toyoda Y, Hagiya Y, Adachi T, et al. MRP class of human ATP binding cassette (ABC) transporters:historical background and new research directions[J]. Xenobiotica, 2008, 38(7-8):833-862.
[11] Rodriguez L, Batlle A, Di Venosa G, et al. Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours[J]. Int J Biochem Cell Biol, 2006, 38(9):1530-1539.
[12] Yonemura Y, Canbay E, Ishibashi H, et al. 5-Aminolevulinic acid fluorescence in detection of peritoneal metastases[J]. Asian Pac J Cancer Prev, 2016, 17(4):2271-2275.
[13] Hornung R, Major A L, McHale M, et al. In vivo detection of metastatic ovarian cancer by means of 5-aminolevulinic acid-induced fluorescence in a rat model[J]. J Am Assoc Gynecol Laparosc, 1998, 5(2):141-148.
[14] Canis M, Botchorishvili R, Berreni N, et al. 5-aminolevulinic acid-induced (ALA) fluorescence for the laparoscopic diagnosis of peritoneal metastasis. AST An experimental study[J]. Surg Endosc, 2001, 15(10):1184-1186.
[15] Chan J K, Monk B J, Cuccia D, et al. Laparoscopic photodynamic diagnosis of ovarian cancer using 5-aminolevulinic acid in a rat model[J]. Gynecol Oncol, 2002, 87(1):64-70.
[16] Lüdicke F, Gabrecht T, Lange N, et al. Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate:a preclinical study[J]. Br J Cancer, 2003, 88(11):1780-1784.
[17] Collinet P, Sabban F, Cosson M, et al. Laparoscopic photodynamic diagnosis of ovarian cancer peritoneal micro metastasis:an experimental study[J]. Photochem Photobiol, 2007, 83(3):647-651.
[18] Guyon L, Farine M O, Lesage J C, et al. Photodynamic therapy of ovarian cancer peritoneal metastasis with hexaminolevulinate:a toxicity study[J]. Photodiagnosis Photodyn Ther, 2014, 11(3):265-274.
[19] Gahlen J, Pietschmann M, Prosst R L, et al. Systemic vs local administration of delta-aminolevulinic acid for laparoscopic fluorescence diagnosis of malignant intra-abdominal tumors:Experimental study[J]. Surg Endosc, 2001, 15(2):196-199.
[20] Kondo Y, Murayama Y, Konishi H, et al. Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid[J]. Int J Oncol, 2014, 45(1):41-46.
[21] Kishi K, Fujiwara Y, Yano M, et al. Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer[J]. J Surg Oncol, 2012, 106(3):294-298.
[22] Lamon J, With T K, Redeker A G. The Hoesch test:bedside screening for urinary porphobilinogen in patients with suspected porphyria[J]. Clin Chem, 1974, 20(11):1438-1440.
[23] Loning M, Diddens H, Kupker W, et al. Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX[J]. Cancer, 2004, 100(8):1650-1656.
[24] Koizumi N, Harada Y, Minamikawa T, et al. Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid[J]. World J Gastroenterol, 2016, 22(3):1289-1296.
[25] Murayama Y, Ichikawa D, Koizumi N, et al. Staging fluorescence laparoscopy for gastric cancer by using 5-aminolevulinic acid[J]. Anticancer Res, 2012,32(12):5421-5427.
[26] Hillemanns P, Wimberger P, Reif J, et al. Photodynamic diagnosis with 5-aminolevulinic acid for intraoperative detection of peritoneal metastases of ovarian cancer:A feasibility and dose finding study[J]. Lasers Surg Med, 2017, 49(2):169-176.
[27] Kamp M A, Fischer I, Buhner J, et al. 5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression[J]. Oncotarget, 2016, 7(41):66776-66789.
[28] Guyotat J, Pallud J, Armoiiry, et al. 5-aminolevulinic acid-protoporphyrin IX fluorescence-guided surgery of high-grade gliomas:a systematic review[J]. Adv Tech Stand Neurosurg, 2016, 43:61-90.
[29] Rink M, Babjuk M, Catto J W, et al. Hexyl aminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer:a critical review of the current literature[J]. Eur Urol, 2013, 64(4):624-638.
[30] Ushimaru Y, Fujiwara Y, Kishi K, et al. Prognostic significance of basing treatment strategy on the results of photodynamic diagnosis on advanced gastric cancer[J]. Ann Surg Oncol, 2017, 24(4):983-989.

5-氨基酮戊酸光动力学诊断腹膜转移癌的研究进展

Research progress on photodynamic detection of peritoneal metastases using 5-aminolevulinic acid (ALA)

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