国家重大自然科学基金国际联合研究计划（81420108009），国家自然科学基金（81630023，81100704，81441029，81441031，81570894），首都卫生研究与发展项目（2011-1017-06），北京市卫生局高层次人才培养计划（2009-2-007，2011-3-039，2011-3-043，2014-3-018）和北京市医院管理局任务计划（SML20150203），张罗长江学者基金和王向东创新研究小组项目基金（IRT13082）。

This study was supported by National Natural Science Fund for the Major International Joint Research Program (81420108009),National Natural Science Foundation of China (81630023,81100704,81441029,81441031,81570894),Capital Health Research and Development Program (2011-1017-06),Beijing Health Bureau Program for High Level Talents (2009-2-007,2011-3-039,2011-3-043,2014-3-018),Beijing Municipal Administration of Hospitals'Mission Plan (SML20150203),L.Z.and X.D.W.from the Program for Changjiang Scholars and Innovative Research Team (IRT13082).