高压氧治疗难治性间质性膀胱炎/膀胱疼痛综合征的疗效观察

doi:10.3969/j.issn.1006-7795.2020.03.022

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (3): 444-448.doi: 10.3969/j.issn.1006-7795.2020.03.022

高压氧治疗难治性间质性膀胱炎/膀胱疼痛综合征的疗效观察

张静¹, 吴栗洋², 杨晶¹, 张鹏²

1. 首都医科大学附属北京朝阳医院高压氧科, 北京 100020;
2. 首都医科大学附属北京朝阳医院泌尿外科, 北京 100020

收稿日期:2020-02-28 出版日期:2020-06-21 发布日期:2020-06-17
通讯作者: 张鹏 E-mail:zhangpenguro@163.com
基金资助:
国家自然科学基金（8177030223）。

Observation of the therapeutic effect of hyperbaric oxygen on refractory interstitial cystitis/bladder pain syndrome

Zhang Jing¹, Wu Liyang², Yang Jing¹, Zhang Peng²

1. Hyperbaric Oxygen Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
2. Urology Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2020-02-28 Online:2020-06-21 Published:2020-06-17
Supported by:
This study was supported by National Natural Science Foundation of China (8177030223).

摘要/Abstract

摘要： 目的探讨高压氧（hyperbaric oxygen，HBO）治疗难治性间质性膀胱炎/膀胱疼痛综合征（interstitial cystitis/bladder pain syndrome，IC/BPS）的临床疗效。方法 IC/BPS患者HBO治疗前和治疗结束后1、3、6个月，记录3 d排尿日记，并评估O' leary-Sant评分、视觉模拟评分（visual analogue scale，VAS）、生活质量指数（quality of life index，QoL）以及盆腔疼痛和尿频、尿急症状（pelvic pain，urgency and frequency，PUF）评分；并在治疗前和治疗后6个月时评估患者的膀胱容量、红斑征和溃疡情况。结果收治的19例患者中，与治疗前相比，其治疗6个月后的24 h排尿次数（11.37±1.98），夜尿次数（1.53±1.17），O' leary-Sant评分（15.95±2.80），VAS评分（31.79±9.53），QoL评分（2.11±0.74），PUF评分（16.16±4.39）及膀胱容量（347.53±75.28）mL均明显改善，差异均有统计学意义（P<0.05）；且24 h排尿次数、O'leary-Sant评分、VAS评分在不同随访时间之间比较差异同样具有统计学意义（P_时间<0.01）。此外，有7例患者"红斑征"转阴，3例患者溃疡愈合。结论高压氧对难治性膀胱炎/膀胱疼痛综合征具有明确疗效。

关键词: 间质性膀胱炎/膀胱疼痛综合征, 高压氧, 症状评分

Abstract: Objective To investigate the clinical efficacy of hyperbaric oxygen (HBO) in the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS). Methods Three-day voiding diary was recorded before HBO treatment and 1, 3 and 6 months after HBO treatment in patients with IC/BPS, and the O'leary-Sant score, visual analogue scale (VAS), quality of life index (QoL), pelvic pain, urgency and frequency (PUF) score were evaluated. Bladder capacity, "erythema sign" and ulcer were evaluated before and 6 months after treatment.Results Totally 19 patients, compared with those before treatment, the 24-hour urination frequency (11.37±1.98), nighttime urination frequency (1.53±1.17), O'leary-Sant score (15.95±2.80), VAS (31.79±9.53), QoL (2.11±0.74), PUF score (16.16±4.39) and bladder capacity (347.53±75.28) mL of the patients after 6 months of treatment improved significantly (P<0.05, respectively).There were also significant differences in 24-hour urination frequency, O'leary-Sant score, and VAS among different follow-up periods (P_time<0.01). In addition, 7 patients with "erythema sign" turned into negative and 3 patients with ulcers healed.Conclusion HBO is effective in the treatment of refractory IC/BPS.

Key words: interstitial cystitis/bladder pain syndrome, hyperbaric oxygen, symptom scores

中图分类号:

R694+.3

张静, 吴栗洋, 杨晶, 张鹏. 高压氧治疗难治性间质性膀胱炎/膀胱疼痛综合征的疗效观察[J]. 首都医科大学学报, 2020, 41(3): 444-448.

Zhang Jing, Wu Liyang, Yang Jing, Zhang Peng. Observation of the therapeutic effect of hyperbaric oxygen on refractory interstitial cystitis/bladder pain syndrome[J]. Journal of Capital Medical University, 2020, 41(3): 444-448.

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高压氧治疗难治性间质性膀胱炎/膀胱疼痛综合征的疗效观察

Observation of the therapeutic effect of hyperbaric oxygen on refractory interstitial cystitis/bladder pain syndrome

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