超声次谐波辅助压力估测技术的影响因素

doi:10.3969/j.issn.1006-7795.2023.06.008

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (6): 953-958.doi: 10.3969/j.issn.1006-7795.2023.06.008

超声次谐波辅助压力估测技术的影响因素

张艳芬^1，2，郑帅¹，陈治光¹，程令刚¹，汪洪斌¹，李睿¹，张雨康¹，张巍¹，何文^1*

1. 首都医科大学附属北京天坛医院超声科，北京 100050；2. 南华大学衡阳医学院附属长沙中心医院超声诊断科，长沙 410007

收稿日期:2023-09-05 出版日期:2023-12-21 发布日期:2023-12-20
通讯作者: 何文 E-mail:hewen@bjtth.org

Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology

Zhang Yanfen^1,2, Zheng Shuaⁱ¹, Chen Zhiguang¹, Cheng Linggang¹, Wang Hongbin¹, Li Rui¹, Zhang Yukang¹, Zhang Wei¹, He Wen^1*

1. Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2. Department of Ultrasound Diagnosis, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410007, China

Received:2023-09-05 Online:2023-12-21 Published:2023-12-20

摘要/Abstract

摘要： 目的探讨超声次谐波辅助压力估测（subharmonic-aided pressure estimation，SHAPE)技术的影响因素。方法在水槽内构建一个动态流量的体外模拟实验。通过SHAPE技术采集不同机械指数 (mechanical index，MI)、超声造影剂浓度及流速下的次谐波幅度值共3 600个，绘制总拟合曲线，量化与压力相关的次谐波幅度快速增长阶段的MI范围及次谐波幅度范围、最佳超声造影剂浓度及流速，明确SHAPE技术应用中的影响因素。结果 ①与压力相关的次谐波快速增长阶段：MI范围为0.04~0.38，次谐波幅度范围－61.94~－12.82 dB； ②快速增长阶段，不同浓度及流速下，次谐波幅度差异有统计学意义（P<0.05);在其他参数一定的情况下，不同浓度、流速和MI下的次谐波幅值最大差异分别为－10.0 dB、－12.84 dB和35.96 dB；③造影剂浓度为3.2 μL/100 mL，流速为8 μL/min时，次谐波幅度与MI的相关系数最高（r=0.973); ④ 增加相同的MI，不同浓度及流速间次谐波幅度变化的相对值进行比较，均无统计学意义（P>0.05)，其中MI相差0.04，次谐波幅度相对值均值约(3.18±1.55)dB，95%可信区间：2.80~3.56 dB；⑤MI的增加导致次谐波幅增加值从9 dB逐渐减小到0.31 dB。结论与声压相关的MI范围及次谐波幅度范围，超声造影剂浓度及流速对SHAPE技术有影响，明确及量化这些影响因素，提高了SHAPE测压的准确性和有效性。

关键词: 次谐波辅助压力估计技术, 次谐波幅度, 超声造影剂, 影响因素

Abstract: Objective To explore the factors influencing the ultrasonic subharmonic-aided pressure estimation （SHAPE)technology. Methods An in vitro simulation of dynamic flow was constructed in a water tank. Three thousand and six hundred subharmonic amplitudes under different mechanical index (MI), sonazoid ultrasound contrast agent concentrations, and flow rates were obtained by SHAPE. The MI and subharmonic amplitude ranges during the pressure-related subharmonic rapid growth stage, the optimal ultrasound contrast agent concentration, and flow rate were quantified using a total fitting curve. Results The MI and sub-harmonic amplitude ranges were 0.04－0.38 and －61.94-－12.82 dB, respectively. When the other parameters were constant, the maximum differences of the subharmonic amplitude under different concentrations, flow rates, and MIs were －10.0 dB,－12.84 dB, and 35.96 dB, respectively. The subharmonic amplitude and MI demonstrated the strongest correlation (r=0.973) when the contrast agent concentration and flow rate were 3.2 μL/100 mL and 8 μL/min, respectively. With MI difference of 0.04, the mean relative subharmonic amplitude was (3.18±1.55)dB (95% CI： 2.80－3.56). Under the same concentration and flow rate, the increase of MI caused a gradual decrease in the subharmonic amplitude from 9 dB to 0.31 dB. Conclusion Identification and quantification of the influencing factors may improve the accuracy and effectiveness of SHAPE.

Key words: subharmonic-aided pressure estimation technology, subharmonic amplitude, ultrasound contrast agent, influencing factors

中图分类号:

R-33

张艳芬, 郑帅, 陈治光, 程令刚, 汪洪斌, 李睿, 张雨康, 张巍, 何文. 超声次谐波辅助压力估测技术的影响因素[J]. 首都医科大学学报, 2023, 44(6): 953-958.

Zhang Yanfen, Zheng Shuai, Chen Zhiguang, Cheng Linggang, Wang Hongbin, Li Rui, Zhang Yukang, Zhang Wei, He Wen. Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology[J]. Journal of Capital Medical University, 2023, 44(6): 953-958.

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超声次谐波辅助压力估测技术的影响因素

Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology

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