血清缺氧诱导因子-1α浓度与脑微出血及认知功能障碍的相关性

doi:10.3969/j.issn.1006-7795.2025.02.007

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (2): 216-227.doi: 10.3969/j.issn.1006-7795.2025.02.007

• 临床研究与方法学应用进展 • 上一篇下一篇

血清缺氧诱导因子-1α浓度与脑微出血及认知功能障碍的相关性

李清¹，赵潇雯²，任敬¹，余淼¹，崔瀚方¹，丁芳园¹，刘昊¹，李琼¹，王凡¹，李青¹，陈希妍¹，路承彪³，李少敏⁴，赵建华^1*

1.新乡医学院第一附属医院神经内科河南省神经修复与蛋白修饰重点实验室河南省老年性痴呆神经修复国际联合实验室，河南新乡 453100；2.福建医科大学临床医学部，福州 350108；3.新乡医学院精神神经医学研究院河南省无创性神经调制国际联合实验室，河南新乡 453003；4.美国哈佛大学医学院布莱根妇女医院神经疾病研究中心，波士顿 02115

收稿日期:2024-11-20 出版日期:2025-04-21 发布日期:2025-04-14
通讯作者: 赵建华 E-mail:051092@xxmu.edu.cn
基金资助:
河南省国际科技合作项目（232102521029）。

The correlation of serum hypoxia-inducible factor-1α level with cerebral microbleeds and cognitive impairment

Li Qing¹, Zhao Xiaowen², Ren Jing¹, Yu Miao¹, Cui Hanfang¹, Ding Fangyuan¹, Liu Hao¹, Li Qiong¹, Wang Fan¹, Li Qing¹, Chen Xiyan¹，Lu Chengbiao³, Li Shaomin⁴, Zhao Jianhua^1*

1.Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia，Henan Key Laboratory of Neurorestoratology and Protein Modification， Department of Neurology, First Afiliated Hospital of Xinxiang Medical University，Xinxiang 453100，Henan Province，China；2.SchooI of CIinicaI Medicine,Fujian Medicine University, Fuzhou 350108,China; 3.International Joint Lab for Non-invasive Neural Modulation of Henan Province，Institute of Psychiatry and Neuroscience，Xinxiang Medical University，Xinxiang 453003，Henan Province，China；4. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston 02115,United States

Received:2024-11-20 Online:2025-04-21 Published:2025-04-14
Supported by:
This study was supported by International Cooperation Project in Science and Technology of Henan Province（232102521029）.

摘要/Abstract

摘要： 目的探讨血清缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)与脑微出血（cerebral microbleeds,CMBs）及认知功能障碍的相关性, 评估HIF-1α对脑小血管病（cerebral small vessel disease,CSVD）相关认知功能障碍的预测价值。方法纳入自 2022 年 6 月至 2023 年 11 月就诊于新乡医学院第一附属医院神经内科的CSVD患者104例，对入组患者进行基本资料统计、头颅核磁检查、认知功能评估、血清HIF-1α检测，统计入组患者CMBs的数量和部位，并进行分组，研究HIF-1α与认知功能和CMBs的相关性，分析 CMBs、认知功能障碍的影响因素，评估HIF-1α对认知功能障碍发生的预测价值。结果不同CMBs严重程度在HIF-1α、认知功能的差异有统计学意义，血清HIF-1α浓度与视空间与执行功能、注意力、延迟回忆呈负相关，与CMBs数量呈正相关， HIF-1α可能是CMBs和CSVD相关认知功能障碍的危险因素，且对CSVD相关认知功能障碍具有潜在的预测价值。结论血清HIF-1α浓度与CMBs数量及 CSVD相关认知功能障碍有关，血清HIF-1α浓度可能对CSVD相关认知功能障碍有一定的预测价值。

关键词: 脑小血管病, 脑微出血, 缺氧诱导因子, 认知功能障碍, 生物标记

Abstract: Objective To explore the correlation between serum hypoxia-inducible factor-1α(HIF-1α) levels and cerebral microbleeds (CMBs) and cognitive impairment and to assess the predictive value of HIF-1α for CSVD-related cognitive impairment. Methods A total of 104 patients with CSVD who attended the Department of Neurology, First Affiliated Hospital of Xinxiang Medical University from June 2022 to November 2023 were enrolled. All enrolled patients were subjected to basic statistics, cranial nuclear magnetic resonance examination, cognitive function assessment, and serum HIF-1α test, and the number and location of CMBs were counted. Based on the above data the enrolled patients were grouped.The correlation between HIF-1α and cognitive function and CMBs was studied the influencing factors of CMBs and cognitive impairment were analyzed, and the predictive value of HIF-1α on the occurrence of cognitive impairment was evaluated. Results There were statistically significant differences in HIF-1α levels and cognitive function among different CMBs groups. Serum HIF-1α levels were significantly negatively correlated with overall cognitive function, visuospatial and executive function, attention, and delayed recall, and serum HIF-1α was positively correlated with the number of CMBs. HIF-1α may be a risk factor for CMBs and cognitive impairment associated with CSVD, and serum HIF-1α has potential in predict the cognitive impairment caused by CSVD. Conclusion Serum levels of HIF-1α were associated with the number of CMB and CSVD-related cognitive impairment, and serum levels of HIF-1α may have a predictive value for CSVD-related cognitive impairment.

Key words: cerebral small vessel disease, cerebral microbleeds, hypoxia-inducible factor, cognitive impairment, biomarker

中图分类号:

李清, 赵潇雯, 任敬, 余淼, 崔瀚方, 丁芳园, 刘昊, 李琼, 王凡, 李青, 陈希妍, 路承彪, 李少敏, 赵建华. 血清缺氧诱导因子-1α浓度与脑微出血及认知功能障碍的相关性[J]. 首都医科大学学报, 2025, 46(2): 216-227.

Li Qing, Zhao Xiaowen, Ren Jing, Yu Miao, Cui Hanfang, Ding Fangyuan, Liu Hao, Li Qiong, Wang Fan, Li Qing, Chen Xiyan, Lu Chengbiao, Li Shaomin, Zhao Jianhua. The correlation of serum hypoxia-inducible factor-1α level with cerebral microbleeds and cognitive impairment[J]. Journal of Capital Medical University, 2025, 46(2): 216-227.

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血清缺氧诱导因子-1α浓度与脑微出血及认知功能障碍的相关性

The correlation of serum hypoxia-inducible factor-1α level with cerebral microbleeds and cognitive impairment

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