个体化生活方式干预对多囊卵巢综合征肥胖患者性功能的影响

doi:10.3969/j.issn.1006-7795.2025.04.005

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (4): 614-619.doi: 10.3969/j.issn.1006-7795.2025.04.005

• 更年期妇科内分泌与生育力保护 • 上一篇下一篇

个体化生活方式干预对多囊卵巢综合征肥胖患者性功能的影响

田玄玄,阮祥燕^*,赵越,金婧,柳顺玉,蒋玲玲

首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科，北京 100026

收稿日期:2025-01-17 出版日期:2025-08-21 发布日期:2025-08-29
通讯作者: 阮祥燕 E-mail:ruanxiangyan@ccmu.edu.cn
基金资助:
北京市医院管理局“登峰”计划专项经费资助（DFL20181401）。

Effect of individualized lifestyle intervention on sexual function in obese patients with polycystic ovary syndrome

Tian Xuanxuan, Ruan Xiangyan^*, Zhao Yue, Jin Jing, Liu Shunyu, Jiang Lingling

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Received:2025-01-17 Online:2025-08-21 Published:2025-08-29
Supported by:
This study was supported by Beijing Municipal Administration of Hospitals’ Ascent Plan (DFL20181401).

摘要/Abstract

摘要： 目的探讨个体化生活方式干预对多囊卵巢综合征（polycystic ovarian syndrome, PCOS）肥胖患者性功能的影响。方法对首都医科大学附属北京妇产医院内分泌科2022年10月~2023年12月就诊的PCOS肥胖患者进行研究。试验组和对照组各160例。两组均使用孕激素调理月经3个月，试验组进行个体化饮食、运动和行为综合生活方式干预，专人随访和体质量管理。对照组给予生活方式干预减重的常规诊疗宣教。采用女性性功能指数(Female Sexual Function Index, FSFI) 量表及简易健康状况检查（12-item Short-Form Health Survey, SF-12）量表评估参与者的性功能及生活质量。收集可能影响性功能的临床资料并测定性激素水平，包括人体测量指标、血清雌二醇、性激素结合球蛋白、总睾酮、生物活性睾酮和硫酸脱氢表雄酮。结果干预3个月后，与对照组相比，试验组的体质量指数、腰围、体脂率、胰岛素抵抗指数、总睾酮、生物活性睾酮和硫酸脱氢表雄酮显著降低（P<0.05），性激素结合球蛋白水平显著增高（P<0.001）。试验组SF-12心理健康领域得分以及FSFI总分、性欲、性高潮和性满意得分均显著增高（P<0.05），而SF-12生理健康领域得分及性唤起、阴道润滑和性交痛得分差异无统计学意义。结论个体化生活方式干预可以更好改善PCOS肥胖患者的性功能及心理健康。

关键词: 多囊卵巢综合征, 生活方式干预, 个体化, 肥胖, 性功能, 性功能障碍

Abstract: Objective To investigate the effect of individualized lifestyle intervention on sexual function in obese patients with polycystic ovarian syndrome (PCOS). Methods The study was conducted on obese patients with PCOS in the Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University from October 2022 to December 2023. There were 160 cases in both the experimental group and the control group, progesterone was administered to both groups for 3 months to regulate menstruation. For women in the experimental group received individualized comprehensive lifestyle intervention combining diet, exercise, and behavior modifications, along with dedicated follow-up and weight management. The control group received routine clinical education for lifestyle intervention aimed at weight loss. Female Sexual Function Index (FSFI) and 12-item Short-Form Health Survey (SF-12) scale were applied to evaluate the sexual function and quality of life. The clinical data that may affect sexual function were collected and sex hormone levels were measured, including anthropometric indicators, estradiol, sex hormone-binding globulin, total testosterone, bioactive testosterone, and dehydroepiandrosterone sulfate in serum. Results After 3 months of intervention, the body mass index, waist circumference, body fat percentage, insulin resistance index, total testosterone, bioactive testosterone and dehydroepiandrosterone sulfate in experimental groups were significantly lower（P<0.05）, and the sex hormone binding globulin level was significantly higher (P<0.001), compared with the control group. SF-12 mental health scores, FSFI total scores, sexual desire, orgasm and sexual satisfaction scores were significantly increased in experimental groups (P<0.05), however, there were no significant differences in SF-12 physical health scores, as well as the scores of sexual arousal, vaginal lubrication, and coital pain. Conclusions Individualized lifestyle intervention can better improve the sexual function and mental health of obese patients with PCOS.

Key words: polycystic ovary syndrome, lifestyle intervention, individuation, obese, sexual function, sexual dysfunction

中图分类号:

R711. 7

田玄玄, 阮祥燕, 赵越, 金婧, 柳顺玉, 蒋玲玲. 个体化生活方式干预对多囊卵巢综合征肥胖患者性功能的影响[J]. 首都医科大学学报, 2025, 46(4): 614-619.

Tian Xuanxuan, Ruan Xiangyan, Zhao Yue, Jin Jing, Liu Shunyu, Jiang Lingling. Effect of individualized lifestyle intervention on sexual function in obese patients with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2025, 46(4): 614-619.

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个体化生活方式干预对多囊卵巢综合征肥胖患者性功能的影响

Effect of individualized lifestyle intervention on sexual function in obese patients with polycystic ovary syndrome

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