关键词: 风湿性心脏病, 二尖瓣狭窄, 二尖瓣修复, 临床结果, 预后, 危险因素

Abstract: Objective  To retrospectively analyze the clinical outcomes of mitral valve repair MVR for treating rheumatic mitral valve disease. Methods  A total of 537 patients with rheumatic mitral valve disease who underwent surgical repair at the Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, from January 2016 to August 2022 were retrospectively included. Clinical and follow-up data were collected. Kaplan-Meier survival curves were constructed to calculate event-free survival rates for the cohort. Additionally, multivariate Cox regression analysis was employed to identify independent risk factors affecting patient prognosis. Results  The mean age of all patients was (57.8 ± 7.5) years, with 144 (26.8%) males and 393 (73.2%) females. The median follow-up time for the cohort was 36.7 months. Survival analysis revealed that the 5-year composite endpoint-free survival rate was 94.1%, the 5-year overall survival rate was 96.7%, and the 5-year freedom from mitral valve reoperation rate was 97.2%. Multivariate Cox regression analysis identified systolic pulmonary artery pressure as an independent risk factor for adverse prognosis (P<0.05). Conclusion  Mitral valve repair can achieve favorable outcomes in appropriately selected patients with rheumatic mitral valve disease, while systolic pulmonary artery pressure serves as an independent risk factor for an adverse prognosis.

Key words: rheumatic heart disease, mitral stenosis, mitral valve repair, clinical outcomes, prognosis, risk factors