微重力环境口腔稳态失衡研究进展

doi:10.3969/j.issn.1006-7795.2025.06.010

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (6): 1026-1032.doi: 10.3969/j.issn.1006-7795.2025.06.010

微重力环境口腔稳态失衡研究进展

张琦^1,2,3，王学玲⁴，周建^1,2,3,5*

1.首都医科大学附属北京口腔医院国际医疗部，北京 100070；2.首都医科大学口腔健康北京实验室, 北京 100069；3.首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室, 北京 100069；4.航天中心医院口腔科，北京100049；5.首都医科大学附属北京天坛医院口腔和全身健康融合与转化研究实验室，北京 100070

收稿日期:2025-10-13 修回日期:2025-10-28 出版日期:2025-12-21 发布日期:2025-12-19
通讯作者: 周建 E-mail:zhoujian@ccmu.edu.cn
基金资助:
首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室，通用技术航天医学研究与转化重点实验室开放课题《航天环境口腔稳态失衡机制与干预策略研究》项目（AMRTOP2504），国家自然科学基金委应急项目（81741106）。

Research progress on oral homeostasis imbalance in microgravity environment

Zhang Qi^1,2,3, Wang Xueling⁴, Zhou Jian^1,2,3,5*

1.Department of International Medical Center, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China; 2. Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China; 3. Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China; 4. Department of Stomatology, Aerospace Center Hospital, Beijing 100049, China; 5. Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Received:2025-10-13 Revised:2025-10-28 Online:2025-12-21 Published:2025-12-19
Supported by:
This study was supported by Laboratory for Clinical Medicine, Capital Medical University, Opening Project of Genertec Key Laboratory of Aerospace Medical Research and Transformation“Research on the mechanism and intervention strategy of oral homeostasis imbalance in the aerospace environment”（AMRTOP2504）, National Natural Science Foundation of China（81741106）.

摘要/Abstract

摘要： 随着载人航天技术的快速发展，太空任务中的微重力环境对航天员口腔稳态的影响日益受到关注。本文综述了微重力环境下口腔稳态失衡的最新研究进展，重点探讨了微重力对颌面部软硬组织（牙槽骨、牙周组织、唾液腺及咀嚼肌），口腔微生物组以及颌面部干细胞的影响。微重力会导致牙槽骨流失、牙周炎症状加重、唾液成分改变及微生物组失衡，进而增加龋病、牙周炎等口腔疾病的风险，但可促进颌面部干细胞的增殖与分化。通过综述微重力对口腔稳态影响的研究进展并展望未来研究方向，为航天员口腔健康防护提供理论依据。

关键词: 微重力, 失重, 口腔稳态, 口腔微生物组, 颌面部干细胞, 骨代谢

Abstract: With the rapid development of manned spaceflight technology, the impact of microgravity environment on the oral homeostasis of astronauts in space missions has attracted increasing attention. This article reviewed the latest research progress of microgravity on oral homeostasis imbalance, focusing on the effects of microgravity on maxillofacial soft and hard tissues (alveolar bone, periodontal tissues, salivary glands and masticatory muscles), oral microbiome, and maxillofacial stem cells. Microgravity can lead to alveolar bone resorption, aggravation of periodontitis, alterations in saliva composition and microbiome imbalance, which in turn increases the risk of oral diseases such as caries and periodontitis, but it can promote the proliferation and differentiation of maxillofacial stem cells. Further, this review outlines prospective research directions of the oral health protection of astronauts.

Key words: microgravity, weightlessness, oral homeostasis, oral microbiome, maxillofacial stem cells, bone metabolism

中图分类号:

张琦, 王学玲, 周建. 微重力环境口腔稳态失衡研究进展[J]. 首都医科大学学报, 2025, 46(6): 1026-1032.

Zhang Qi, Wang Xueling, Zhou Jian. Research progress on oral homeostasis imbalance in microgravity environment[J]. Journal of Capital Medical University, 2025, 46(6): 1026-1032.

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微重力环境口腔稳态失衡研究进展

Research progress on oral homeostasis imbalance in microgravity environment

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