孕早期血红蛋白水平与妊娠期糖尿病发生的关系研究

doi:10.3969/j.issn.1006-7795.2026.01.010

首都医科大学学报 ›› 2026, Vol. 47 ›› Issue (1): 82-86.doi: 10.3969/j.issn.1006-7795.2026.01.010

孕早期血红蛋白水平与妊娠期糖尿病发生的关系研究

韩文莉¹,邹丽颖^2*,郑薇³,赵越⁴

1.首都医科大学附属北京友谊医院妇产科，北京 100050；2.首都医科大学附属北京妇产医院/北京妇幼保健院围产医学部，北京 100026； 3.首都医科大学附属北京妇产医院/北京妇幼保健院围产内分泌代谢科，北京 100026；4.首都医科大学附属北京妇产医院/北京妇幼保健院医务处，北京 100026

收稿日期:2025-09-16 修回日期:2025-12-05 出版日期:2026-02-21 发布日期:2026-02-02
通讯作者: 邹丽颖 E-mail:zouliying@ccmu.edu.cn
基金资助:
国家自然科学基金青年科学基金资助项目（82301916）。

Correlation between hemoglobin and gestational diabetes mellitus in early pregnancy

Han Wenli¹, Zou Liying^2*, Zheng Wei³, Zhao Yue⁴

1.Department of Gynecology and Obstetrics,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China；2. Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing 100026,China；3.Division of Endocrinology and Metabolism, Department of Obstetrics，Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital，Beijing 100026,China；4.Department of Medical Administration Division, Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing 100026,China

Received:2025-09-16 Revised:2025-12-05 Online:2026-02-21 Published:2026-02-02
Supported by:
This study was supported by National Natural Science Foundation of China - Youth Science Fund（82301916）.

摘要/Abstract

摘要： 目的探讨孕早期血红蛋白（hemoglobin,HGB）水平与妊娠期糖尿病（gestational diabetes mellitus,GDM）发生的风险关系。方法选取2024年1月1日至2024年6月30日于首都医科大学附属北京妇产医院分娩的1 044例无孕前糖尿病的单胎孕妇的临床资料，收集其年龄、孕前体质量指数（body mass index，BMI）及孕早期（孕6～10周）首次HGB实验室检查结果，根据孕中期口服葡萄糖耐量试验（oral glucose tolerance test,OGTT）结果分为两组：GDM组（173例）和非GDM组（871例），运用Logistic回归分析孕早期HGB与GDM发生之间的关系。结果本研究中GDM发病率为16.57%，GDM组孕妇年龄、BMI及孕早期HGB水平均高于非GDM组，差异有统计学意义（P＜0.05）。孕早期HGB与孕中期OGTT 0 h血糖(r=0.069,P=0.025)，OGTT 1h血糖（r=0.150,P＜0.001），OGTT 2 h血糖（r=0.124,P＜0.001）均呈显著正相关。孕早期HGB水平是影响GDM发生的独立危险因素（OR=1.02，95%CI：1.004～1.046，P=0.021）。并且按照年龄、BMI分层后孕早期HGB仍然为GDM发生的独立危险因素（P均＜0.05），结果稳定可靠。随着孕早期HGB水平升高，GDM发生风险升高。结论孕早期HGB水平升高与GDM发生显著相关，对GDM发生具有预测价值。

关键词: 孕早期, 妊娠期糖尿病, 血红蛋白, 危险因素, 血糖, 预测价值

Abstract: Objective To investigate the relationship between the hemoglobin levels in early pregnancy and risk of gestational diabetes mellitus (GDM). Methods Clinical data of 1 044 pregnant women without preconception diabetes who gave birth in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 1, 2024 to June 30, 2024 were selected, and their age, preconception body mass index (BMI) and the results of the first hemoglobin laboratory test in early pregnancy(at 6－10 weeks of gestations) were collected. According to the results of oral glucose tolerance test (OGTT) in the second trimester, the patients were divided into GDM group(173 cases) and non-GDM group(871 cases). Logistic regression was used to analyze the relationship between hemoglobin (HGB) and GDM in the first trimester. Results In this study, the incidence of GDM was 16.57%, The Age, BMI and HGB in the early pregnancy of the GDM group were all higher than those of the non-GDM group, and the differences were statistically significant (P < 0.05). The HGB in the early pregnancy was significantly positively correlated with the blood glucose at 0 h (r= 0.069, P=0.025), 1h (r=0.15, P < 0.001) and 2 h (r=0.124, P<0.001) of OGTT in the mid-pregnancy. HGB concentration in the first trimester was an independent risk factor affecting the occurrence of GDM (OR=1.02,95%CI:1.004－1.046, P=0.021)，and after stratification by age and BMI,HGB levels in the early pregnancy stage remained an independent risk factor for the occurrence of GDM (all P<0.05), and the results were reliable.As the HGB level rises during the early stage of pregnancy, the risk of developing GDM increases. Conclusion The increase of HGB level in early pregnancy is significantly correlated with the occurrence of GDM, which has predictive value for the occurrence of GDM.

Key words: early pregnancy, gestational diabetes mellitus, hemoglobin, risk factors, blood glucose, predictive value

中图分类号:

R714.2

韩文莉, 邹丽颖, 郑薇, 赵越. 孕早期血红蛋白水平与妊娠期糖尿病发生的关系研究[J]. 首都医科大学学报, 2026, 47(1): 82-86.

Han Wenli, Zou Liying, Zheng Wei, Zhao Yue. Correlation between hemoglobin and gestational diabetes mellitus in early pregnancy[J]. Journal of Capital Medical University, 2026, 47(1): 82-86.

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孕早期血红蛋白水平与妊娠期糖尿病发生的关系研究

Correlation between hemoglobin and gestational diabetes mellitus in early pregnancy

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