表观遗传学在偏头痛致病与诊疗中的研究进展

doi:10.3969/j.issn.1006-7795.2026.01.023

摘要/Abstract

摘要： 偏头痛是一种严重的慢性神经血管疾病，严重影响患者的生命质量，其病理生理机制复杂，受到基因和环境的共同影响，现有药物的治疗效果欠佳。表观遗传学是连接环境因素与遗传因素的重要桥梁，越来越多的研究发现表观遗传参与了偏头痛的先兆、发作与慢性化等过程，可作为偏头痛诊断与预后判断的生物标志物，为偏头痛治疗提供了潜在靶点。本文集中梳理了偏头痛表观遗传学领域的研究，以期发掘可信的偏头痛生物标志物与治疗靶点。

关键词: 偏头痛, 表观遗传, DNA甲基化, 组蛋白修饰, 非编码RNA, 生物标志物

Abstract: Migraine is a severe chronic neurovascular disorder that significantly impacts patients' quality of life. Its pathophysiology is intricate, influenced by both genetic and environmental factors, yet existing treatments remain less than satisfactory. Epigenetics serves as a crucial bridge linking environmental and genetic factors. Increasing evidence indicates that epigenetic mechanisms are involved in migraine auras, attacks, and chronicity. These processes may serve as biomarkers for migraine diagnosis and prognosis, and as novel therapeutic targets. This paper provides a comprehensive review of the epigenetics of migraine, aiming to identify reliable biomarkers and therapeutic targets that advance migraine management.

Key words: migraine, epigenetics, DNA methylation, histone modification, non-coding RNA, biomarkers

中图分类号:

R394

张孟曦, 庞淼一, 王培培, 李纤, 王云, 杨菲. 表观遗传学在偏头痛致病与诊疗中的研究进展[J]. 首都医科大学学报, 2026, 47(1): 180-189.

Zhang Mengxi, Pang Miaoyi, Wang Peipei, Li Qian, Wang Yun, Yang Fei. Research progress of epigenetics in the pathogenesis and treatment of migraine[J]. Journal of Capital Medical University, 2026, 47(1): 180-189.

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