视网膜神经节细胞能回响周期刺激的时间模式

doi:10.3969/j.issn.1006-7795.2026.04.016

首都医科大学学报 ›› 2026, Vol. 47 ›› Issue (4): 754-765.doi: 10.3969/j.issn.1006-7795.2026.04.016

视网膜神经节细胞能回响周期刺激的时间模式

李雪瑕¹，邵攀^2*，李大鹏^1*

1. 首都医科大学基础医学院神经生物学系，首都医科大学基础临床联合实验室，北京100069；2. 中国科学院生物物理研究所，北京100101

收稿日期:2026-04-08 修回日期:2026-05-26 出版日期:2026-08-21 发布日期:2026-07-26
通讯作者: 邵攀, 李大鹏 E-mail:lidapeng2021@ccmu.edu.cn; ncuskshaopan@163.com
基金资助:
国家自然科学基金项目（32271030）,北京市自然科学基金项目(L2510042)。

Retinal ganglion cells echo the temporal pattern of periodic stimulation

Li Xuexia¹, Shao Pan^2*, Li Dapeng^1*

1. Department of Neurobiology, School of Basic Medical Sciences, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China; 2. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Received:2026-04-08 Revised:2026-05-26 Online:2026-08-21 Published:2026-07-26
Supported by:
This study was supported by the National Natural Science Foundation of China (32271030), Natural Science Foundation of Beijing(L2510042).

摘要/Abstract

摘要： 目的探讨大鼠视网膜神经节细胞（retinal ganglion cells，RGCs）长时程记录方式及其对周期性光刺激模式的反应。方法于大鼠视交叉（optic chiasm，OC）或视束（optic tract，OPT）进行在体单单位记录并给予周期性时序光刺激。结果该方法可稳定记录至少2 h。刺激后自发放电序列与刺激期间放电序列的相似性高于刺激前，提示RGCs可短暂保留并表征周期性光刺激的时间模式。刺激前自发放电活动存在节律性，其强度可影响这种表征。结论大鼠RGCs能够表征从数十毫秒到分钟量级的外源性时间模式，并能响应周期性光刺激。

关键词: 视网膜神经节细胞, 光刺激, 周期性, 动作电位, 神经元表征, 视交叉, 细胞外记录, 电生理学

Abstract: Objective To develop a method for long-term recording of retinal ganglion cells (RGCs) in rats and to examine their responses to periodic light stimulation patterns. Methods In vivo single-unit recordings were performed in the optic chiasm (OC) or optic tract (OPT) of rats during periodic temporal light stimulation. Results This method enabled stable single-unit recording for at least 2 h. The spontaneous firing pattern after stimulation was more similar to the firing pattern during stimulation than that before stimulation, indicating that RGCs could transiently retain and represent the temporal pattern of periodic light stimulation. Spontaneous activity before stimulation showed rhythmicity, and the strength of this rhythmic activity influenced this representation. Conclusion Rat RGCs can represent exogenous temporal patterns over timescales ranging from tens of milliseconds to minutes and respond to periodic light stimulation.

Key words: retinal ganglion cells, photic stimulation, periodicity, action potentials, neuronal representation, optic chiasm, extracellular recording, electrophysiology

中图分类号:

Q 189

李雪瑕, 邵攀, 李大鹏. 视网膜神经节细胞能回响周期刺激的时间模式[J]. 首都医科大学学报, 2026, 47(4): 754-765.

Li Xuexia, Shao Pan, Li Dapeng. Retinal ganglion cells echo the temporal pattern of periodic stimulation[J]. Journal of Capital Medical University, 2026, 47(4): 754-765.

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视网膜神经节细胞能回响周期刺激的时间模式

Retinal ganglion cells echo the temporal pattern of periodic stimulation

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