BCG在小鼠抗绿脓杆菌感染中的作用

首都医科大学学报 ›› 1985, Vol. 6 ›› Issue (2): 125-130.

BCG在小鼠抗绿脓杆菌感染中的作用

安云庆, 程松高, 李郁英, 滕树华

北京第二医学院微生物学教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1985-04-15 发布日期:1985-04-15

Effect of BCG on Pseudomonas Aeruginosa Infection in Mice

An Yunqing

Received:1900-01-01 Revised:1900-01-01 Online:1985-04-15 Published:1985-04-15

摘要/Abstract

摘要： 本工作对免疫调节剂BCG处理的小鼠抗绿脓杆菌(PA)感染作用做了初步观察,对其机理进行了初步研究。预先经BCG处理(1mg/只,静脉注射)的小鼠对3倍LD₅₀ PA活菌攻击的抵抗力显著高于对照小鼠,但对粗制PA内毒素攻击的耐受能力低于对照小鼠。实验观察表明,BCG对小鼠的作用一方面可增强固定吞噬细胞清除PA的能力,另一方面BCG又可封闭小鼠网状内皮系统对内毒素的清除功能。

Abstract: A Preliminory observation and mechanism survey about the effect of immune regulator-BCG on the capacity of resistance against pseudomonas aeruginosa (PA) infection in mice were reported in the present paper. The mice preinfected with BCG (1mg/per mouse iv) were shown to be highly resistant to subsequent challenge with PA (3LD₅₀), and susceptible to lethal effect of rough PA endotoxin. The results of our experiment showed that BCG-induced resistance to PA was related to an enhanced eliminating ability produced by fixed phagocytes of mice and BCG-induced susceptibility to PA endotoxin might be attributed to blockage of reticulo-endothelial system of mice by BCG. The relationship of experimental results was discussed.

安云庆;程松高;李郁英;滕树华. BCG在小鼠抗绿脓杆菌感染中的作用[J]. 首都医科大学学报, 1985, 6(2): 125-130.

An Yunqing. Effect of BCG on Pseudomonas Aeruginosa Infection in Mice[J]. Journal of Capital Medical University, 1985, 6(2): 125-130.