关键词: 肾上腺髓质, 纹状体, 尾状核, 移植, 肾上腺嗜铬细胞, 多巴胺, 震颤麻痹, 大鼠

Abstract: Homotypic adrenal medulla were grafted into the denervated caudate nucleuses of the rats. It has been shown that the graft implanted into the rat brain survives and improves behavioral abnormalities.These grafted adrenal chromaffin cells contained catecholamines,as indicated by SPGmethod.Some cells retained the typical appearance of normal chromaff in cells,while other cells had undergone varying degrees of transformation toward the adrenergic-neuron phenotype.Most of those cells had become somewhat elongated or developed short coarse processes.Concentration of CA were studied by a spectrophotofluorometer using dissected host brain tissue. Concentration of dopaminc(DA)in the grafts were very high.So called “overamount”transplants were found to provide a more extensive behavioural recovery as compared with that receiving“anormalamount” The results of present paper were very significant for the future clinical application.

Key words: adrenal medulla, sttiatum, caudate nucleus, transplantation, adrenal chromaffin cell, catecholamine, dopamine, Parkinsonism, rat