首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (4): 274-276.
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李娟, 李美玲, 孔祥环, 苏忆兰, 沈家琴, 罗政红, 李永顺
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Li Juan
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摘要： 对新型消毒剂碘附Ⅰ号进行了急性毒性(包括经口LD50、经皮LD50和粘膜及皮肤的刺激试验)和致敏作用的研究。结果表明:大、小鼠LD50说明该碘附Ⅰ号属于低毒物质,豚鼠经皮LD50未能测出。粘膜刺激试验:碘附Ⅰ号原液对眼粘膜有强刺激作用;50%碘附Ⅰ号液有中等刺激作用;25%、5%、2%及1%的碘附Ⅰ号液无任何刺激作用。家兔皮肤刺激试验显示无皮肤刺激作用。豚鼠皮肤致敏试验结果无致敏作用。因此,我们认为碘附Ⅰ号液是一种有前途的皮肤及医疗器械消毒剂。
关键词: 碘附, 消毒剂, 毒性试验, 致敏作用, 豚鼠
Abstract: Iodophor-No.1 is a new disinfectant.We carried out the following stu- dies:acute toxicity test and sensitization test of Iodophor-No.1.The re- sults showed that the Iodophor-No.1 belongs to low toxic substance,by the orally taking LD50 test in mice and rats.Acute skin toxicity cannot determine in guinea pigs;irritate test of the mucosa membrance of the eyes by the thick solution of Iodophor-No.1 showed a strong irritate effect 50 per cent Iodophor-No.1 showed middle irritate effect,25,5,2, and 1 per cent are without any irritating properties;skin irritate test of rabbits did not show any irritate effects;The sensitization test by guinea pigs was negative. Therefore,we think that Iodophor-No.1 is a promising disinfectant for skin and medical instrument.
Key words: Iodophor, disinfectant, toxicity test, sensitization
李娟;李美玲;孔祥环;苏忆兰;沈家琴;罗政红;李永顺. “碘附1号”消毒剂的安全性毒性研究[J]. 首都医科大学学报, 1987, 8(4): 274-276.
Li Juan. Studies on Toxicity of Iodophor-No.1[J]. Journal of Capital Medical University, 1987, 8(4): 274-276.
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https://journal03.magtech.org.cn/Jweb_sdykdxxb/CN/Y1987/V8/I4/274
