人工合成TP5的免疫刺激作用

首都医科大学学报 ›› 1990, Vol. 11 ›› Issue (4): 295-298,325.

人工合成TP5的免疫刺激作用

刘俊达¹, 李昌龙¹, 施宏伟¹, 高林², 刘延津², 盛树力²

1. 北京医院老年病研究所;2. 北京市神经外科研究所

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1990-10-15 发布日期:1990-10-15

Immunostimulatory Effect of Artificial Systhetic TP5

Liu Junda¹, Li Changlong¹, Shi HongWei¹, Gao Lin², Liu Yanjing², Sheng Shuli²

Received:1900-01-01 Revised:1900-01-01 Online:1990-10-15 Published:1990-10-15

摘要/Abstract

摘要：

研究了人工合成胸腺五肽(TP5)的免疫刺激作用。结果表明,TP5对小鼠的脾重和脾组织学都有显著影响。实验组动物脾淋巴细胞的E-玫瑰花结形成率及转化率、PFC皆明显高于对照组动物。讨论了TP5的性质、作用机理和临床应用的前景。

关键词: 胸腺五肽, 脾淋巴细胞, 免疫刺激作用, 抗体形成细胞, E-玫瑰花结形成

Abstract:

This study reported on the systhesis of thymopoietin pentapeptide (TP5) and its biochemical properties. We have investigated the immunostimulatory effect of this artificial systhetic TP5. The results showed that TP5 has markedly promotive influence on weight and histological characteristic of spleen of mice, The transformation, rate of E-rosete formation and plaque forming cell (PFC) of spleen lymphocyte in experimental animal group that were injected TP5 are significantly higher than that of control group. Author discussed mechanism of effect and prospect of clinical trial of TP5 in future.

Key words: thymopoietin pentapeptide (TP5), spleen lymphocyte, immunostimulatory effect, plaque forming cell (PFC), E-rosette formation

刘俊达;李昌龙;施宏伟;高林;刘延津;盛树力. 人工合成TP5的免疫刺激作用[J]. 首都医科大学学报, 1990, 11(4): 295-298,325.

Liu Junda;Li Changlong;Shi HongWei;Gao Lin;Liu Yanjing;Sheng Shuli. Immunostimulatory Effect of Artificial Systhetic TP5[J]. Journal of Capital Medical University, 1990, 11(4): 295-298,325.