KA8肽的合成及其对五肽胃泌素刺激大鼠胃液分泌的抑制作用

首都医科大学学报 ›› 1990, Vol. 11 ›› Issue (4): 299-301.

KA8肽的合成及其对五肽胃泌素刺激大鼠胃液分泌的抑制作用

张家瑾¹, 张绍东¹, 张辉¹, 关玲玲¹, 盛树力¹, 梁丕霞²

1. 北京市神经外科研究所;2. 北京天坛医院

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1990-10-15 发布日期:1990-10-15

Synthesis of KA8 Peptide and its Inhibitory Effect on Pentagastric-Stimulated Gastric Acid Secretion in Rats

Zhang Jiajin¹, Zhang Shaodong¹, Zhang Hui¹, Guan Lingling¹, Sheng Shuli¹, Liang Peixia²

Received:1900-01-01 Revised:1900-01-01 Online:1990-10-15 Published:1990-10-15

摘要/Abstract

摘要： 胃酸分泌调节肽是一个37肽。1-29肽段即为胰高糖素,而C-端8肽称为KA8。用固相法合成了此八肽,并观察了它的生物活性。实验结果表明五肽胃泌素能明显刺激胃酸分泌,但这种刺激作用可被预先给予的KA8所抑制,因此,KA8可能是一种胃酸分泌调节肽。

关键词: KA8, OXM, 五肽胃泌素, 肽合成

Abstract: KA8 peptide is a c-terminal octapeptide 30～37 of oxyntomodulin 1～37. Oxyntomodulin 1～29 is a glucagon, which can increasa the concentration of blood glucose, but oxyntomodulin has a obvious inhibition of gastrie acid secretion. In order to understand the KA8 biologieal activity, we have synthesized KA8 and injected to rats before administration of pentagastrin. The experiment showed that pentagastrin stimulated definitively gastric acid secretion. However, KA8 could eliminated the pentagastrin induced gastric acid secretion. Our result reveals that KA8 plaies probably a important role in the regulation of gastric acid secretion.

Key words: KA8 peptide, oxyntomodulin, pentagastrin, peptide synthesis

张家瑾;张绍东;张辉;关玲玲;盛树力;梁丕霞. KA8肽的合成及其对五肽胃泌素刺激大鼠胃液分泌的抑制作用[J]. 首都医科大学学报, 1990, 11(4): 299-301.

Zhang Jiajin;Zhang Shaodong;Zhang Hui;Guan Lingling;Sheng Shuli;Liang Peixia. Synthesis of KA8 Peptide and its Inhibitory Effect on Pentagastric-Stimulated Gastric Acid Secretion in Rats[J]. Journal of Capital Medical University, 1990, 11(4): 299-301.

[1]	王霄虹;左谦;寿吉平;艾厚喜;姬志娟;刘大川;盛树力. 胃酸分泌调节肽和KA8肽的生物活性研究[J]. 首都医科大学学报, 1994, 15(1): 34-37.
[2]	赵咏梅;王霄虹;董士勤;盛树力. KA8肽对酒精所致大鼠胃粘膜损伤的保护作用[J]. 首都医科大学学报, 1994, 15(1): 38-40.
[3]	张绍东;关玲玲;梁丕霞;王霄虹;张家瑾;杨昭徐;张辉;陈雁江;盛树力. KA8肽抑制TRH和冷束缚引起的胃酸分泌增加[J]. 首都医科大学学报, 1990, 11(4): 302-304.